- Thermodynamics of Ligand Binding to a Heterogeneous RNA Population in the Malachite Green Aptamer
[作者:Sokoloski, JE; Dombrowski, SE; Bevilacqua, PC,期刊:Biochemistry, 页码:565-572 , 文章类型: Article,,卷期:2012年51-1]
- The malachite green aptamer binds two closely related ligands, malachite green (MG) and tetramethylrosamine (TMR), with nearly equal affinity. The MG ligand consists of three phenyl rings emanating from a central carbon,...
- Insights from Crystal Structures into the Opposite Effects on RNA Affinity Caused by the S- and R-6 '-Methyl Backbone Modifications of 3 '-Fluoro Hexitol Nucleic Acid
[作者:Pallan, PS; Yu, JH; Allerson, CR; Swayze, EE; Seth, P; Egli, M,期刊:Biochemistry, 页码:7-9 , 文章类型: Article,,卷期:2012年51-1]
- Locked nucleic acid (LNA) analogues with 2',4'-bridged sugars show promise in antisense applications. S-5'-Me-LNA has high RNA affinity, and modified oligonucleotides show weakened immune stimulation in vivo. Conversely,...
- Nanomechanical Recognition of Sphingomyelin-Rich Membrane Domains by Atomic Force Microscopy
[作者:Wang, T; Shogomori, H; Hara, M; Yamada, T; Kobayashi, T,期刊:Biochemistry, 页码:74-82 , 文章类型: Article,,卷期:2012年51-1]
- Sphingomyelin (SM) is a reservoir of signaling lipids and forms specific lipid domains in biomembranes together with cholesterol. In this study, atomic force microscopy (AFM) and force measurement were applied to investi...
- Head-to-Tail Interaction between Amphotericin B and Ergosterol Occurs in Hydrated Phospholipid Membrane
[作者:Umegawa, Y; Nakagawa, Y; Tahara, K; Tsuchikawa, H; Matsumori, N; Oishi, T; Murata, M,期刊:Biochemistry, 页码:83-89 , 文章类型: Article,,卷期:2012年51-1]
- Amphotericin B (AmB) is thought to exert its antifungal activity by forming an ion-channel assembly in the presence of ergosterol. In the present study we aimed to elucidate the mode of molecular interactions between AmB...
- The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics
[作者:Saraboji, K; Hakansson, M; Genheden, S; Diehl, C; Qvist, J; Weininger, U; Nilsson, UJ; Leffler, H; Ryde, U; Akke, M; Logan, DT,期刊:Biochemistry, 页码:296-306 , 文章类型: Article,,卷期:2012年51-1]
- The recognition of carbohydrates by proteins is a fundamental aspect of communication within and between living cells. Understanding the molecular basis of carbohydrate-protein interactions is a prerequisite for the rati...
- Dihydroxybenzoic Acid Isomers Differentially Dissociate Soluble Biotinyl-A beta(1-42) Oligomers
[作者:LeVine, H; Lampe, L; Abdelmoti, L; Augelli-Szafran, CE,期刊:Biochemistry, 页码:307-315 , 文章类型: Article,,卷期:2012年51-1]
- Polyphenolic compounds including a number of natural products such as resveratrol, curcumin, catechin derivatives, and nordihydroguaiaretic acid have effects on the assembly of A beta fibrils and oligomers as well as on ...
- Cyclostreptin Derivatives Specifically Target Cellular Tubulin and Further Map the Paclitaxel Site
[作者:Calvo, E; Barasoain, I; Matesanz, R; Pera, B; Camafeita, E; Pineda, O; Hamel, E; Vanderwal, CD; Andreu, JM; Lopez, JA; Diaz, JF,期刊:Biochemistry, 页码:329-341 , 文章类型: Article,,卷期:2012年51-1]
- Cyclostreptin is the first microtubule-stabilizing agent whose mechanism of action was discovered to involve formation of a covalent bond with tubulin. Treatment of cells with cyclostreptin irreversibly stabilizes their ...
- Association of RrgA and RrgC into the Streptococcus pneumoniae Pilus by Sortases C-2 and C-3
[作者:El Mortaji, L; Fenel, D; Vernet, T; Di Guilmi, AM,期刊:Biochemistry, 页码:342-352 , 文章类型: Article,,卷期:2012年51-1]
- Pili are surface-exposed virulence factors involved in the adhesion of bacteria to host cells. The human pathogen Streptococcus pneumoniae expresses a pilus composed of three structural proteins, RrgA, RrgB, and RrgC, an...
- Conformational Selection by the aIF2 GTPase: A Molecular Dynamics Study of Functional Pathways
[作者:Satpati, P; Simonson, T,期刊:Biochemistry, 页码:353-361 , 文章类型: Article,,卷期:2012年51-1]
- Archaeal initiation factor 2 (aIF2) is a GTPase involved in protein biosynthesis. In its GTP-bound, "ON" conformation, it binds an initiator tRNA and carries it to the ribosome. In its GDP-bound, "OFF" conformation, it d...
- Dependence of DNA-Protein Cross-Linking via Guanine Oxidation upon Local DNA Sequence As Studied by Restriction Endonuclease Inhibition
[作者:Madison, AL; Perez, ZA; To, P; Maisonet, T; Rios, EV; Trejo, Y; Ochoa-Paniagua, C; Reno, A; Stemp, EDA,期刊:Biochemistry, 页码:362-369 , 文章类型: Article,,卷期:2012年51-1]
- Oxidative damage plays a causative role in many diseases, and DNA-protein cross-linking is one important consequence of such damage. It is known that GG and GGG sites are particularly prone to one-electron oxidation, and...
- Drug Interactions with Bacillus anthracis Topoisomerase IV: Biochemical Basis for Quinolone Action and Resistance
[作者:Aldred, KJ; McPherson, SA; Wang, PF; Kerns, RJ; Graves, DE; Turnbough, CL; Osheroff, N,期刊:Biochemistry, 页码:370-381 , 文章类型: Article,,卷期:2012年51-1]
- Bacillus anthracis, the causative agent of anthrax, is considered a serious threat as a bioweapon. The drugs most commonly used to treat anthrax are quinolones, which act by increasing the levels of DNA cleavage mediated...
- Searching for DNA Lesions: Structural Evidence for Lower- and Higher-Affinity DNA Binding Conformations of Human Alkyladenine DNA Glycosylase
[作者:Setser, JW; Lingaraju, GM; Davis, CA; Samson, LD; Drennan, CL,期刊:Biochemistry, 页码:382-390 , 文章类型: Article,,卷期:2012年51-1]
- To efficiently repair DNA, human alkyladenine DNA glycosylase (AAG) must search the million-fold excess of unmodified DNA bases to find a handful of DNA lesions. Such a search can be facilitated by the ability of glycosy...
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