- Nitrative and oxidative DNA damage caused by K-ras mutation in mice
[作者:Ohnishi, S; Saito, H; Suzuki, N; Ma, N; Hiraku, Y; Murata, M; Kawanishi, S,期刊:Biochemical and Biophysical Research Communications, 页码:236-240 , 文章类型: Article,,卷期:2011年413-2]
- Ras mutation is important for carcinogenesis. Carcinogenesis consists of multi-step process with mutations in several genes. We investigated the role of DNA damage in carcinogenesis initiated by K-ras mutation, using con...
- Tigutcystatin, a cysteine protease inhibitor from Triatoma infestans midgut expressed in response to Trypanosoma cruzi
[作者:Buarque, DS; Spindola, LMN; Martins, RM; Braz, GRC; Tanaka, AS,期刊:Biochemical and Biophysical Research Communications, 页码:241-247 , 文章类型: Article,,卷期:2011年413-2]
- The insect Triatoma infestans is a vector of Trypanosoma cruzi, the etiological agent of Chagas disease. A cDNA library was constructed from T. infestans anterior midgut, and 244 clones were sequenced. Among the EST sequ...
- RNA polymerase II degradation in response to rapamycin is not mediated through ubiquitylation
[作者:Jouvet, N; Poschmann, J; Douville, J; Marrakchi, R; Ramotar, D,期刊:Biochemical and Biophysical Research Communications, 页码:248-253 , 文章类型: Article,,卷期:2011年413-2]
- In Saccharomyces cerevisiae, the immunosuppressor rapamycin engenders the degradation of excessive RNA polymerase II leading to growth arrest but the regulation of this process is not known yet. Here, we show that this m...
- Protective effect of catechin in type I Gaucher disease cells by reducing endoplasmic reticulum stress
[作者:Lee, YJ; Kim, SJ; Heo, TH,期刊:Biochemical and Biophysical Research Communications, 页码:254-258 , 文章类型: Article,,卷期:2011年413-2]
- Gaucher disease (GD) is the most common lysosomal storage disorder (LSD) and is divided into three phenotypes, I, II, and III. Type I is the most prevalent form and has its onset in adulthood. The degree of endoplasmic r...
- Sanguinarine is an allosteric activator of AMP-activated protein kinase
[作者:Choi, J; He, N; Sung, MK; Yang, Y; Yoon, S,期刊:Biochemical and Biophysical Research Communications, 页码:259-263 , 文章类型: Article,,卷期:2011年413-2]
- We found that a natural product, Sanguinarine, directly interacts with AMPK and enhances its enzymatic activity. Cell-based assays confirmed that cellular AMPK and the downstream acetyl-CoA carboxylase (ACC) were phospho...
- Vaspin protects vascular endothelial cells against free fatty acid-induced apoptosis through a phosphatidylinositol 3-kinase/Akt pathway
[作者:Jung, CH; Lee, WJ; Hwang, JY; Seol, SM; Kim, YM; Lee, YL; Park, JY,期刊:Biochemical and Biophysical Research Communications, 页码:264-269 , 文章类型: Article,,卷期:2011年413-2]
- Vaspin, an adipocytokine recently identified in a rat model of type 2 diabetes, has been suggested to have an insulin-sensitizing effect. However, the exact mechanism underlying this action has not been fully elucidated....
- Loss of DLK expression in WI-38 human diploid fibroblasts induces a senescent-like proliferation arrest
[作者:Daviau, A; Couture, JP; Blouin, R,期刊:Biochemical and Biophysical Research Communications, 页码:282-287 , 文章类型: Article,,卷期:2011年413-2]
- DLK, a serine/threonine kinase that functions as an upstream activator of the mitogen-activated protein kinase (MAPK) pathways, has been shown to play a role in development, cell differentiation, apoptosis and neuronal r...
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