- Inactivation of prolyl hydroxylase domain (PHD) protein by epigallocatechin (EGCG) stabilizes hypoxia-inducible factor (HIF-1 alpha) and induces hepcidin (Hamp) in rat kidney
[作者:Manalo, DJ; Baek, JH; Buehler, PW; Struble, E; Abraham, B; Alayash, AI,期刊:Biochemical and Biophysical Research Communications, 页码:421-426 , 文章类型: Article,,卷期:2011年416-3-4]
- HIF-1 alpha plays a key role in iron uptake and transport in the liver, whose activity is tightly linked to the repression of hepcidin (Hamp). Hump prevents intestinal iron uptake and cellular efflux by negatively modula...
- Expanding the utility of heptamer-type sgRNA for TRUE gene silencing
[作者:Sano, T; Takahashi, M; Nozaki, T; Takahashi, Y; Tamura, M; Nashimoto, M,期刊:Biochemical and Biophysical Research Communications, 页码:427-432 , 文章类型: Article,,卷期:2011年416-3-4]
- tRNase Z(L)-utilizing efficacious gene silencing (TRUE gene silencing) is a novel technology for suppressing gene expression. TRUE gene silencing is based on a unique enzymatic property of mammalian tRNase Z(L), which is...
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