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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共47条记录   Observations in APP Bitransgenic Mice Suggest that Diffuse and Compact Plaques Form via Independent Processes in Alzheimer's Disease [作者：Lord, A; Philipson, O; Klingstedt, T; Westermark, G; Hammarstrom, P; Nilsson, KPR; Nilsson, LNG,期刊：American Journal of Pathology, 页码：2286-2298 , 文章类型： Article，,卷期：2011年178-5] Studies of familial Alzheimer's disease suggest that mis-folding and aggregation of amyloid-beta (A beta) peptides initiate the pathogenesis. The Arctic mutation of A beta precursor protein (APP) results in AD and Arctic... Adipose Tissue-Derived Stem Cell in Vitro Differentiation in a Three-Dimensional Dental Bud Structure [作者：Ferro, F; Spelat, R; Falini, G; Gallelli, A; D'Aurizio, F; Puppato, E; Pandolfi, M; Beltrami, AP; Cesselli, D; Beltrami, CA; Ambesi-Impiombato, FS; Curcio, F,期刊：American Journal of Pathology, 页码：2299-2310 , 文章类型： Article，,卷期：2011年178-5] Tooth morphogenesis requires sequential and reciprocal interactions between the cranial neural crest derived mesenchymal cells and the stomadial epithelium, which regulate tooth morphogenesis and differentiation. We show... Lack of TNF-alpha-Induced MMP-9 Production and Abnormal E-Cadherin Redistribution Associated with Compromised Fusion in MCP-1-Null Macrophages [作者：Skokos, EA; Charokopos, A; Khan, K; Wanjala, J; Kyriakides, TR,期刊：American Journal of Pathology, 页码：2311-2321 , 文章类型： Article，,卷期：2011年178-5] Homotypic cell fusion occurs in several cell types including macrophages in the formation of foreign body giant cells. Previously, monocyte chemoattractant protein-1 (MCP-1) was demonstrated to be required for foreign bo... Adipose Injury-Associated Factors Mitigate Hypoxia in Ischemic Tissues through Activation of Adipose-Derived Stem/Progenitor/Stromal Cells and Induction of Angiogenesis [作者：Eto, H; Suga, H; Inoue, K; Aoi, N; Kato, H; Araki, J; Doi, K; Higashino, T; Yoshimura, K,期刊：American Journal of Pathology, 页码：2322-2332 , 文章类型： Article，,卷期：2011年178-5] Based on the analysis of exudates from injured adipose tissue, we prepared a mixture containing the injury-associated growth factors at the same proportion as the exudates, named adipose injury cocktail (AIC). We hypothe... Protein Phosphatase 2A Catalytic Subunit alpha (PP2Ac alpha) Maintains Survival of Committed Erythroid Cells in Fetal Liver Erythropoiesis through the STAT5 Pathway [作者：Chen, WQ; Gu, PY; Jiang, X; Ruan, HB; Li, CJ; Gao, X,期刊：American Journal of Pathology, 页码：2333-2343 , 文章类型： Article，,卷期：2011年178-5] Suppression of programmed cell death is critical for the final maturation of red blood cells and depends largely on the anti-apoptotic effects of EpoR-STAT5-Bcl-x(L) signaling. As the major eukaryotic serine/thureonine p... Identification of Oncostatin M as a STAT5-Dependent Mediator of Bone Marrow Remodeling in KIT D816V-Positive Systemic Mastocytosis [作者：Hoermann, G; Cerny-Reiterer, S; Perne, A; Klauser, M; Hoetzenecker, K; Klein, K; Mullauer, L; Groger, M; Nijman, SMB; Klepetko, W; Valent, P; Mayerhofer, M,期刊：American Journal of Pathology, 页码：2344-2356 , 文章类型： Article，,卷期：2011年178-5] Systemic mastocytosis is a neoplastic disease of mast cells harboring the activating KIT mutation D816V. In most patients, mast cell infiltration in the bone marrow is accompanied by marked microenvironinent alterations,... Selection of Brain Metastasis-Initiating Breast Cancer Cells Determined by Growth on Hard Agar [作者：Guo, LX; Fan, D; Zhang, FH; Price, JE; Lee, JS; Marchetti, D; Fidler, IJ; Langley, RR,期刊：American Journal of Pathology, 页码：2357-2366 , 文章类型： Article，,卷期：2011年178-5] An approach that facilitates rapid isolation and characterization of tumor cells with enhanced metastatic potential is highly desirable. Here, we demonstrate that plating GI-101A human breast cancer cells on hard (0.9%) ... Skp2 Overexpression Is Associated with Loss of BRCA2 Protein in Human Prostate Cancer [作者：Arbini, AA; Greco, M; Yao, JL; Bourne, P; Marra, E; Hsieh, JT; di Sant'Agnese, PA; Moro, L,期刊：American Journal of Pathology, 页码：2367-2376 , 文章类型： Article，,卷期：2011年178-5] BRCA2 (breast cancer 2, early onset) is a tumor suppressor gene that confers increased susceptibility for prostate cancer (PCa). Previous in vitro experiments demonstrated that Skp2, an E3 ubiquitin ligase aber-rantly ov... CCN3 Impairs Osteoblast and Stimulates Osteoclast Differentiation to Favor Breast Cancer Metastasis to Bone [作者：Ouellet, V; Tiedemann, K; Mourskaia, A; Fong, JE; Tran-Thanh, D; Amir, E; Clemons, M; Perbal, B; Komarova, SV; Siegel, PM,期刊：American Journal of Pathology, 页码：2377-2388 , 文章类型： Article，,卷期：2011年178-5] Bone is a preferred site for breast cancer metastasis, causing pain, fractures, spinal cord compressions, and hypercalcemia, all of which can significantly diminish the patient's quality of life. We identified CCN3 as a ... S100A4 Expression in Xenograft Tumors of Human Carcinoma Cell Lines Is Induced by the Tumor Microenvironment [作者：Wetting, HL; Hadler-Olsen, E; Magnussen, S; Rikardsen, O; Steigen, SE; Sundkvist, E; Loennechen, T; Kanapathippillai, P; Kildalsen, H; Winberg, JO; Uhlin-Hansen, L; Svineng, G,期刊：American Journal of Pathology, 页码：2389-2396 , 文章类型： Article，,卷期：2011年178-5] Increased expression of the invasion- and metastasis-associated protein S100A4 is found in many types of cancer, but the regulation of S100A4 expression Is poorly understood. The microenvironment surrounding tumors has a... Pirin Inhibits Cellular Senescence in Melanocytic Cells [作者：Licciulli, S; Luise, C; Scafetta, G; Capra, M; Giardina, G; Nuciforo, P; Bosari, S; Viale, G; Mazzarol, G; Tonelli, C; Lanfrancone, L; Alcalay, M,期刊：American Journal of Pathology, 页码：2397-2406 , 文章类型： Article，,卷期：2011年178-5] Cellular senescence has been widely recognized as a tumor suppressing mechanism that acts as a barrier to cancer development after oncogenic stimuli. A prominent in vivo model of the senescence barrier is represented by ... Overexpression of a Chromatin Remodeling Factor, RSF-1/HBXAP, Correlates with Aggressive Oral Squamous Cell Carcinoma [作者：Fang, FM; Li, CF; Huang, HY; Lai, MT; Chen, CM; Chiu, IW; Wang, TL; Tsai, FJ; Shih, IM; Sheu, JJC,期刊：American Journal of Pathology, 页码：2407-2415 , 文章类型： Article，,卷期：2011年178-5] RSF-1, also known as hepatitis B X-antigen associated protein (HBXAP), is a subunit of an ISWI chromatin remodeling complex, remodeling and spacing factor (RSF). Recent studies have provided new evidence that chromatin r... Interleukin-1 beta Inhibition Prevents Choroidal Neovascularization and Does Not Exacerbate Photoreceptor Degeneration [作者：Lavalette, S; Raoul, W; Houssier, M; Camelo, S; Levy, O; Calippe, B; Jonet, L; Behar-Cohen, F; Chemtob, S; Guillonneau, X; Combadiere, C; Sennlaub, F,期刊：American Journal of Pathology, 页码：2416-2423 , 文章类型： Article，,卷期：2011年178-5] The pro-inflammatory cytokine IL-1 beta has been shown to promote angiogenesis. It can have a neurotoxic or neuroprotective effect. Here, we have studied the expression of IL-1 beta in vivo and the effect of the IL-1 rec... Ultrastructural Analysis Reveals cAMP-Dependent Enhancement of Microvascular Endothelial Barrier Functions via Rac1-Mediated Reorganization of Intercellular Junctions [作者：Spindler, V; Peter, D; Harms, GS; Asan, E; Waschke, J,期刊：American Journal of Pathology, 页码：2424-2436 , 文章类型： Article，,卷期：2011年178-5] Evidence exists that cAMP stabilizes the endothelial barrier, in part via activation of the small GTPase Rac1. However, despite the high medical relevance of this signaling pathway, the mechanistic effects on intercellul... Physiological Contribution of CD44 as a Ligand for E-Selectin during Inflammatory T-Cell Recruitment [作者：Nacher, M; Blazquez, AB; Shao, BJ; Matesanz, A; Prophete, C; Berin, MC; Frenette, PS; Hidalgo, A,期刊：American Journal of Pathology, 页码：2437-2446 , 文章类型： Article，,卷期：2011年178-5] Endothelial selectins guide the migration of inflammatory T cells to extralymphoid tissues. Whereas P-selectin glycoprotein ligand-1 (PSGL-1) functions as the exclusive ligand for P-selectin, it acts in coordination with...