- Human Leukocyte Antigen Class II Transgenic Mouse Model Unmasks the Significant Extrahepatic Pathology in Toxic Shock Syndrome
[作者:Tilahun, AY; Marietta, EV; Wu, TT; Patel, R; David, CS; Rajagopalan, G,期刊:American Journal of Pathology, 页码:2760-2773 , 文章类型: Article,,卷期:2011年178-6]
- Among the exotoxins produced by Staphylococcus aureus and Streptococcus pyogenes, the superantigens (SAgs) are the most potent T-cell activators known to date. SAgs are implicated in several serious diseases including to...
- Role of p47phox in Antigen-Presenting Cell-Mediated Regulation of Humoral Immunity in Mice
[作者:Vasilevsky, S; Liu, Q; Koontz, SM; Kastenmayer, R; Shea, K; Jackson, SH,期刊:American Journal of Pathology, 页码:2774-2782 , 文章类型: Article,,卷期:2011年178-6]
- Microbial-induced inflammation is important for eliciting humoral immunity. Genetic defects of NADPH oxidase 2-based proteins interrupt phagocyte superoxide generation and are the basis for the human immnunodeficiency ch...
- Effect of Macrophage Migration Inhibitory Factor (MIF) in Human Placental Explants Infected with Toxoplasma gondii Depends on Gestational Age
[作者:Gomes, AD; Silva, DAD; Silva, NM; Barbosa, BD; Franco, PS; Angeloni, MB; Fermino, ML; Roque-Barreira, MC; Bechi, N; Paulesu, LR; dos Santos, MC; Mineo, JR; Ferro, EAV,期刊:American Journal of Pathology, 页码:2792-2801 , 文章类型: Article,,卷期:2011年178-6]
- Because macrophage migration inhibitory factor (MIF) is a key cytokine in pregnancy and has a role in inflammatory response and pathogen defense, the objective of the present study was to investigate the effects of MIF i...
- Placental TNF-alpha Signaling in Illness-Induced Complications of Pregnancy
[作者:Carpentier, PA; Dingman, AL; Palmer, TD,期刊:American Journal of Pathology, 页码:2802-2810 , 文章类型: Article,,卷期:2011年178-6]
- Maternal infections are implicated in a variety of complications during pregnancy, including pregnancy loss, prematurity, and increased risk of neurodevelopmental disorders in the child. Here, we show in mice that even m...
- Inflammation Induced by Infection Potentiates Tau Pathological Features in Transgenic Mice
[作者:Sy, M; Kitazawa, M; Medeiros, R; Whitman, L; Cheng, D; Lane, TE; LaFerla, FM,期刊:American Journal of Pathology, 页码:2811-2822 , 文章类型: Article,,卷期:2011年178-6]
- Comorbidities that promote the progression of Alzheimer's disease (AD) remain to be uncovered and evaluated in animal models. Because elderly individuals are vulnerable to viral and bacterial infections, these microbial ...
- Neuroprotective Effects of the Cellular Prion Protein in Autoimmune Optic Neuritis
[作者:Williams, SK; Fairless, R; Weise, J; Kalinke, U; Schulz-Schaeffer, W; Diem, R,期刊:American Journal of Pathology, 页码:2823-2831 , 文章类型: Article,,卷期:2011年178-6]
- Although the pathologic role of the prion protein in transmissible spongiform encephalopathic diseases has been widely investigated, the physiologic role of the cellular prion protein (PrP(C)) is not known. Among the man...
- Identification of Cells with Colony-Forming Activity, Self-Renewal Capacity, and Multipotency in Ovarian Endometriosis
[作者:Chan, RWS; Ng, EHY; Yeung, WSB,期刊:American Journal of Pathology, 页码:2832-2844 , 文章类型: Article,,卷期:2011年178-6]
- Endometriosis, the growth of endometrial tissue outside the uterine cavity, is a common gynecological disorder affecting 10% to 15% of women in their reproductive years. Retrograde menstrual shedding containing endometri...
- RANKL Expression Specifically Observed in Vivo Promotes Epithelial Mesenchymal Transition and Tumor Progression
[作者:Yamada, T; Tsuda, M; Takahashi, T; Totsuka, Y; Shindoh, M; Ohba, Y,期刊:American Journal of Pathology, 页码:2845-2856 , 文章类型: Article,,卷期:2011年178-6]
- Recent findings have focused attention on the molecular consequences of the microenvironment in tumor progression, but events occurring in cancer cells themselves in response to their ambient conditions remain obscure. H...
- In Vivo Invasion of Head and Neck Squamous Cell Carcinoma Cells Does Not Require Macrophages
[作者:Smirnova, T; Adomako, A; Locker, J; Van Rooijen, N; Prystowsky, MB; Segall, JE,期刊:American Journal of Pathology, 页码:2857-2865 , 文章类型: Article,,卷期:2011年178-6]
- Invasion of tumor cells into the local stroma is an important component in cancer progression. Here we report studies of the in vivo invasion of head and neck squamous cell carcinoma (HNSCC) cells in response to applied ...
- Secretory Leukocyte Protease Inhibitor (SLPI) Expression and Tumor Invasion in Oral Squamous Cell Carcinoma
[作者:Wen, J; Nikitakis, NG; Chaisuparat, R; Greenwell-Wild, T; Gliozzi, M; Jin, WW; Adli, A; Moutsopoulos, N; Wu, TX; Warburton, G; Wahl, SM,期刊:American Journal of Pathology, 页码:2866-2878 , 文章类型: Article,,卷期:2011年178-6]
- Differential expression of secretory leukocyte protease inhibitor (SLPI) impacts on tumor progression. SLPI directly inhibits elastase and other serine proteases, and regulates matrix metalloproteinases, plasminogen acti...
- Microcalcifications in Early Intimal Lesions of Atherosclerotic Human Coronary Arteries
[作者:Roijers, RB; Debernardi, N; Cleutjens, JPM; Schurgers, LJ; Mutsaers, PHA; van der Vusse, GJ,期刊:American Journal of Pathology, 页码:2879-2887 , 文章类型: Article,,卷期:2011年178-6]
- Although calcium (Ca) precipitation may play a pathogenic role in atherosclerosis, information on temporal patterns of microcalcifications in human coronary arteries, their relation to expression of calcification-regulat...
- Pericyte Requirement for Anti-Leak Action of Angiopoietin-1 and Vascular Remodeling in Sustained Inflammation
[作者:Fuxe, J; Tabruyn, S; Colton, K; Zaid, H; Adams, A; Baluk, P; Lashnits, E; Morisada, T; Le, T; O'Brien, S; Epstein, DM; Koh, GY; McDonald, DM,期刊:American Journal of Pathology, 页码:2897-2909 , 文章类型: Article,,卷期:2011年178-6]
- Blood vessel leakiness is an early, transient event in acute inflammation but can also persist as vessels undergo remodeling in sustained inflammation. Angiopoietin/Tie2 signaling can reduce the leakiness through changes...
- Mouse Vein Graft Hemodynamic Manipulations to Enhance Experimental Utility
[作者:Yu, P; Nguyen, BT; Tao, M; Bai, YN; Ozaki, CK,期刊:American Journal of Pathology, 页码:2910-2919 , 文章类型: Article,,卷期:2011年178-6]
- Mouse models serve as a tool to study vein graft failure. However, in wild-type mice, there is limited intimal hyperplasia, hampering efforts to identify anti-intimal hyperplasia therapies. Furthermore, vein graft wall r...
- Increased Vascular Delivery and Efficacy of Chemotherapy after Inhibition of Platelet-Derived Growth Factor-B
[作者:Falcon, BL; Pietras, K; Chou, J; Chen, D; Sennino, B; Hanahan, D; McDonald, DM,期刊:American Journal of Pathology, 页码:2920-2930 , 文章类型: Article,,卷期:2011年178-6]
- Inhibition of platelet-derived growth factor-B (PDGF-B) has multiple effects on tumors, including loss of pericytes, regression of some vessels, normalization of other vessels, and reduction of interstitial pressure. PDG...
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