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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共55条记录   A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield [作者：Pejchal, R; Doores, KJ; Walker, LM; Khayat, R; Huang, PS; Wang, SK; Stanfield, RL; Julien, JP; Ramos, A; Crispin, M; Depetris, R; Katpally, U; Marozsan, A; Cupo, A; Maloveste, S; Liu, Y; McBride, R; Ito, Y; Sanders, RW; Ogohara, C; Paulson, JC; Feizi, T; Scanlan, CN; Wong, CH; Moore, JP; Olson, WC; Ward, AB; Poignard, P; Schief, WR; Burton, DR; Wilson, IA,期刊：Science, 页码：1097-1103 , 文章类型： Article，,卷期：2011年334-6059] The HIV envelope (Env) protein gp120 is protected from antibody recognition by a dense glycan shield. However, several of the recently identified PGT broadly neutralizing antibodies appear to interact directly with the H... A Cocoon of Freshly Accelerated Cosmic Rays Detected by Fermi in the Cygnus Superbubble [作者：Ackermann, M; Ajello, M; Allafort, A; Baldini, L; Ballet, J; Barbiellini, G; Bastieri, D; Belfiore, A; Bellazzini, R; Berenji, B; Blandford, RD; Bloom, ED; Bonamente, E; Borgland, AW; Bottacini, E; Brigida, M; Bruel, P; Buehler, R; Buson, S; Caliandro, GA; Cameron, RA; Caraveo, PA; Casandjian, JM; Cecchi, C; Chekhtman, A; Cheung, CC; Chiang, J; Ciprini, S; Claus, R; Cohen-Tanugi, J; de Angelis, A; de Palma, F; Dermer, CD; Silva, EDE; Drell, PS; Dumora, D; Favuzzi, C; Fegan, SJ; Focke, WB; Fortin, P; Fukazawa, Y; Fusco, P; Gargano, F; Germani, S; Giglietto, N; Giordano, F; Giroletti, M; Glanzman, T; Godfrey, G; Grenier, IA; Guillemot, L; Guiriec, S; Hadasch, D; Hanabata, Y; Harding, AK; Hayashida, M; Hayashi, K; Hays, E; Johannesson, G; Johnson, AS; Kamae, T; Katagiri, H; Kataoka, J; Kerr, M; Knodlseder, J; Kuss, M; Lande, J; Latronico, L; Lee, SH; Longo, F; Loparco, F; Lott, B; Lovellette, MN; Lubrano, P; Martin, P; Mazziotta, MN; McEnery, JE; Mehault, J; Michelson, PF; Mitthumsiri, W;,期刊：Science, 页码：1103-1107 , 文章类型： Article，,卷期：2011年334-6059] The origin of Galactic cosmic rays is a century-long puzzle. Indirect evidence points to their acceleration by supernova shockwaves, but we know little of their escape from the shock and their evolution through the turbu... Fermi Detection of a Luminous gamma-Ray Pulsar in a Globular Cluster [作者：Freire, PCC; Abdo, AA; Ajello, M; Allafort, A; Ballet, J; Barbiellini, G; Bastieri, D; Bechtol, K; Bellazzini, R; Blandford, RD; Bloom, ED; Bonamente, E; Borgland, AW; Brigida, M; Bruel, P; Buehler, R; Buson, S; Caliandro, GA; Cameron, RA; Camilo, F; Caraveo, PA; Cecchi, C; Celik, O; Charles, E; Chekhtman, A; Cheung, CC; Chiang, J; Ciprini, S; Claus, R; Cognard, I; Cohen-Tanugi, J; Cominsky, LR; de Palma, F; Dermer, CD; Silva, EDE; Dormody, M; Drell, PS; Dubois, R; Dumora, D; Espinoza, CM; Favuzzi, C; Fegan, SJ; Ferrara, EC; Focke, WB; Fortin, P; Fukazawa, Y; Fusco, P; Gargano, F; Gasparrini, D; Gehrels, N; Germani, S; Giglietto, N; Giordano, F; Giroletti, M; Glanzman, T; Godfrey, G; Grenier, IA; Grondin, MH; Grove, JE; Guillemot, L; Guiriec, S; Hadasch, D; Harding, AK; Johannesson, G; Johnson, AS; Johnson, TJ; Johnston, S; Katagiri, H; Kataoka, J; Keith, M; Kerr, M; Knodlseder, J; Kramer, M; Kuss, M; Lande, J; Latronico, L; Lee, SH; Lemoine-Goumard, M; Longo, F; Loparco, F; Lovellette,期刊：Science, 页码：1107-1110 , 文章类型： Article，,卷期：2011年334-6059] We report on the Fermi Large Area Telescope's detection of gamma-ray (>100 mega-electron volts) pulsations from pulsar J1823-3021A in the globular cluster NGC 6624 with high significance (similar to 7 sigma). Its gamma-r... A Homonuclear Molecule with a Permanent Electric Dipole Moment [作者：Li, W; Pohl, T; Rost, JM; Rittenhouse, ST; Sadeghpour, HR; Nipper, J; Butscher, B; Balewski, JB; Bendkowsky, V; Low, R; Pfau, T,期刊：Science, 页码：1110-1114 , 文章类型： Article，,卷期：2011年334-6059] Permanent electric dipole moments in molecules require a breaking of parity symmetry. Conventionally, this symmetry breaking relies on the presence of heteronuclear constituents. We report the observation of a permanent ... Discovery of an alpha-Amino C-H Arylation Reaction Using the Strategy of Accelerated Serendipity [作者：McNally, A; Prier, CK; MacMillan, DWC,期刊：Science, 页码：1114-1117 , 文章类型： Article，,卷期：2011年334-6059] Serendipity has long been a welcome yet elusive phenomenon in the advancement of chemistry. We sought to exploit serendipity as a means of rapidly identifying unanticipated chemical transformations. By using a high-throu... Pelagic Fishing at 42,000 Years Before the Present and the Maritime Skills of Modern Humans [作者：O'Connor, S; Ono, R; Clarkson, C,期刊：Science, 页码：1117-1121 , 文章类型： Article，,卷期：2011年334-6059] By 50,000 years ago, it is clear that modern humans were capable of long-distance sea travel as they colonized Australia. However, evidence for advanced maritime skills, and for fishing in particular, is rare before the ... Phanerozoic Earth System Evolution and Marine Biodiversity [作者：Hannisdal, B; Peters, SE,期刊：Science, 页码：1121-1124 , 文章类型： Article，,卷期：2011年334-6059] The Phanerozoic fossil record of marine animal diversity covaries with the amount of marine sedimentary rock. The extent to which this covariation reflects a geologically controlled sampling bias remains unknown. We show... Climate Change, Keystone Predation, and Biodiversity Loss [作者：Harley, CDG,期刊：Science, 页码：1124-1127 , 文章类型： Article，,卷期：2011年334-6059] Climate change can affect organisms both directly via physiological stress and indirectly via changing relationships among species. However, we do not fully understand how changing interspecific relationships contribute ... Experimental Evolution of Reduced Sex Ratio Adjustment Under Local Mate Competition [作者：Macke, E; Magalhaes, S; Bach, F; Olivieri, I,期刊：Science, 页码：1127-1129 , 文章类型： Article，,卷期：2011年334-6059] Theory predicts that local mate competition (LMC) favors the evolution of female-biased sex ratios. Empirical support of this prediction is indirect and comes from comparative studies or from studies showing that individ... Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy [作者：Chonghaile, TN; Sarosiek, KA; Vo, TT; Ryan, JA; Tammareddi, A; Moore, VD; Deng, J; Anderson, KC; Richardson, P; Tai, YT; Mitsiades, CS; Matulonis, UA; Drapkin, R; Stone, R; DeAngelo, DJ; McConkey, DJ; Sallan, SE; Silverman, L; Hirsch, MS; Carrasco, DR; Letai, A,期刊：Science, 页码：1129-1133 , 文章类型： Article，,卷期：2011年334-6059] Cytotoxic chemotherapy targets elements common to all nucleated human cells, such as DNA and microtubules, yet it selectively kills tumor cells. Here we show that clinical response to these drugs correlates with, and may... Transplanted Hypothalamic Neurons Restore Leptin Signaling and Ameliorate Obesity in db/db Mice [作者：Czupryn, A; Zhou, YD; Chen, X; McNay, D; Anderson, MP; Flier, JS; Macklis, JD,期刊：Science, 页码：1133-1137 , 文章类型： Article，,卷期：2011年334-6059] Evolutionarily old and conserved homeostatic systems in the brain, including the hypothalamus, are organized into nuclear structures of heterogeneous and diverse neuron populations. To investigate whether such circuits c... Polarization of PAR Proteins by Advective Triggering of a Pattern-Forming System [作者：Goehring, NW; Trong, PK; Bois, JS; Chowdhury, D; Nicola, EM; Hyman, AA; Grill, SW,期刊：Science, 页码：1137-1141 , 文章类型： Article，,卷期：2011年334-6059] In the Caenorhabditis elegans zygote, a conserved network of partitioning-defective (PAR) polarity proteins segregates into an anterior and a posterior domain, facilitated by flows of the cortical actomyosin meshwork. Th... Degradation of Paternal Mitochondria by Fertilization-Triggered Autophagy in C. elegans Embryos [作者：Sato, M; Sato, K,期刊：Science, 页码：1141-1144 , 文章类型： Article，,卷期：2011年334-6059] The mitochondrial genome is believed to be maternally inherited in many eukaryotes. Sperm-derived paternal mitochondria enter the oocyte cytoplasm upon fertilization and then normally disappear during early embryogenesis... Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission [作者：Al Rawi, S; Louvet-Vallee, S; Djeddi, A; Sachse, M; Culetto, E; Hajjar, C; Boyd, L; Legouis, R; Galy, V,期刊：Science, 页码：1144-1147 , 文章类型： Article，,卷期：2011年334-6059] In sexual reproduction of most animals, the spermatozoon provides DNA and centrioles, together with some cytoplasm and organelles, to the oocyte that is being fertilized. Paternal mitochondria and their genomes are gener... Deep Human Genealogies Reveal a Selective Advantage to Be on an Expanding Wave Front [作者：Moreau, C; Bherer, C; Vezina, H; Jomphe, M; Labuda, D; Excoffier, L,期刊：Science, 页码：1148-1150 , 文章类型： Article，,卷期：2011年334-6059] Since their origin, human populations have colonized the whole planet, but the demographic processes governing range expansions are mostly unknown. We analyzed the genealogy of more than one million individuals resulting... Stress-Related Noradrenergic Activity Prompts Large-Scale Neural Network Reconfiguration [作者：Hermans, EJ; van Marle, HJF; Ossewaarde, L; Henckens, MJAG; Qin, SZ; van Kesteren, MTR; Schoots, VC; Cousijn, H; Rijpkema, M; Oostenveld, R; Fernandez, G,期刊：Science, 页码：1151-1153 , 文章类型： Article，,卷期：2011年334-6059] Acute stress shifts the brain into a state that fosters rapid defense mechanisms. Stress-related neuromodulators are thought to trigger this change by altering properties of large-scale neural populations throughout the ...