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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共38条记录   Inhibition of x(c)(-) transporter-mediated cystine uptake by sulfasalazine analogs [作者：Shukla, K; Thomas, AG; Ferraris, DV; Hin, N; Sattler, R; Alt, J; Rojas, C; Slusher, BS; Tsukamoto, T,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6184-6187 , 文章类型： Article，,卷期：2011年21-20] A series of sulfasalazine analogs were synthesized and tested for their ability to block cystine-glutamate antiporter system x(c)(-) using L-[(14)C]cystine as a substrate. Replacement of sulfasalazine's diazo group with ... Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor [作者：Liddle, J; Atkinson, FL; Barker, MD; Carter, PS; Curtis, NR; Davis, RP; Douault, C; Dickson, MC; Elwes, D; Garton, NS; Gray, M; Hayhow, TG; Hobbs, CI; Jones, E; Leach, S; Leavens, K; Lewis, HD; McCleary, S; Neu, M; Patel, VK; Preston, AGS; Ramirez-Molina, C; Shipley, TJ; Skone, PA; Smithers, N; Somers, DO; Walker, AL; Watson, RJ; Weingarten, GG,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6188-6194 , 文章类型： Article，,卷期：2011年21-20] The lead optimisation of the diaminopyrimidine carboxamide series of spleen tyrosine kinase inhibitors is described. The medicinal chemistry strategy was focused on optimising the human whole blood activity whilst achiev... Ferrocenyl chalcone difluoridoborates inhibit HIV-1 integrase and display low activity towards cancer and endothelial cells [作者：Monserrat, JP; Al-Safi, RI; Tiwari, KN; Quentin, L; Chabot, GG; Vessieres, A; Jaouen, G; Neamati, N; Hillard, EA,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6195-6197 , 文章类型： Article，,卷期：2011年21-20] We report here the discovery of a potent series of HIV-1 integrase (IN) inhibitors based on the ferrocenyl chalcone difluoridoborate structure. Ten new compounds have been synthesized and were generally found to have sim... Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. Part 2: Synthesis of novel triplet drugs with the epoxymethano structure (capped homotriplet) [作者：Nagase, H; Koyano, K; Wada, N; Hirayama, S; Watanabe, A; Nemoto, T; Nakajima, M; Nakao, K; Mochizuki, H; Fujii, H,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6198-6202 , 文章类型： Article，,卷期：2011年21-20] An improved synthetic method for triplet drugs with the 1,3,5-trioxazatriquinane skeleton was developed that used p-toluenesulfonylmethyl isocyanide (TosMIC) instead of 1,3-dithiane. Using the improved method, we synthes... Novel 4-azasteroidal N-glycoside analogues bearing sugar-like D ring: Synthesis and anticancer activities [作者：Huang, LH; Wang, YG; Xu, G; Zhang, XH; Zheng, YF; He, HL; Fu, WZ; Liu, HM,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6203-6205 , 文章类型： Article，,卷期：2011年21-20] A series of novel N-glycoside analogues with 4-azasteroid moiety bearing sugar-like D ring were conveniently synthesized by constructing the core dihydropyran ring embedded in 4-azasteroidal skeleton which was prepared f... Ligand based virtual screening and biological evaluation of inhibitors of chorismate mutase (Rv1885c) from Mycobacterium tuberculosis H37Rv (vol 17, pg 3053, 2007) [作者：Agrawal, H; Kumar, A; Bal, NC; Siddiqi, MI; Arora, A,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6206-6206 , 文章类型： Correction，,卷期：2011年21-20]