- JNJ-26070109 [(R)4-Bromo-N-[1-(2,4-difluoro-phenyl)-ethyl]-2-(quinoxaline-5-sulfonylamino)-benzamide]: A Novel, Potent, and Selective Cholecystokinin 2 Receptor Antagonist with Good Oral Bioavailability
[作者:Morton, MF; Barrett, TD; Freedman, J; Li, LN; Rizzolio, MC; Prendergast, CE; Wu, XD; Moreno, V; Pyati, J; Figueroa, K; Cagnon, L; Lagaud, G; Donck, LV; Ghoos, E; Allison, B; Rabinowitz, MH; Shankley, NP,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:328-336 , 文章类型: Article,,卷期:2011年338-1]
- JNJ-26070109 [(R)4-bromo-N-[1-(2,4-difluoro-phenyl)ethyl]-2-(quinoxaline-5-sulfonylamino)-benzamide] is a representative of a new chemical class of competitive antagonists of cholecystokinin 2 (CCK2) receptors. In this s...
- Fasudil and Ozagrel in Combination Show Neuroprotective Effects on Cerebral Infarction after Murine Middle Cerebral Artery Occlusion
[作者:Koumura, A; Hamanaka, J; Kawasaki, K; Tsuruma, K; Shimazawa, M; Hozumi, I; Inuzuka, T; Hara, H,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:337-344 , 文章类型: Article,,卷期:2011年338-1]
- Rho kinase (ROCK), one of the serine/threonine kinases, is involved in pathologic conditions, and its activation causes neuronal cell death. Fasudil, a selective ROCK inhibitor, has been reported to cause increased cereb...
- The Metabotropic Glutamate Receptor 7 Allosteric Modulator AMN082: A Monoaminergic Agent in Disguise?
[作者:Rizzo, SJS; Leonard, SK; Gilbert, A; Dollings, P; Smith, DL; Zhang, MY; Di, L; Platt, BJ; Neal, S; Dwyer, JM; Bender, CN; Zhang, J; Lock, T; Kowal, D; Kramer, A; Randall, A; Huselton, C; Vishwanathan, K; Tse, SY; Butera, J; Ring, RH; Rosenzweig-Lipson, S; Hughes, ZA; Dunlop, J,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:345-352 , 文章类型: Article,,卷期:2011年338-1]
- Metabotropic glutamate receptor 7 (mGluR7) remains the most elusive of the eight known mGluRs primarily because of the limited availability of tool compounds to interrogate its potential therapeutic utility. The discover...
- Metabolism of [D(10)]Phenanthrene to Tetraols in Smokers for Potential Lung Cancer Susceptibility Assessment: Comparison of Oral and Inhalation Routes of Administration
[作者:Zhong, Y; Wang, J; Carmella, SG; Hochalter, JB; Rauch, D; Oliver, A; Jensen, J; Hatsukami, DK; Upadhyaya, P; Zimmerman, C; Hecht, SS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:353-361 , 文章类型: Article,,卷期:2011年338-1]
- Polycyclic aromatic hydrocarbons (PAHs) are believed to be among the causative agents for lung cancer in smokers. PAHs require metabolic activation for carcinogenicity. One pathway produces diol epoxides that react with ...
- Rapid, Nongenomic Stimulation of Multidrug Resistance Protein 2 (Mrp2) Activity by Glucocorticoids in Renal Proximal Tubule
[作者:Prevoo, B; Miller, DS; van de Water, FM; Wever, KE; Russel, FGM; Flik, G; Masereeuw, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:362-371 , 文章类型: Article,,卷期:2011年338-1]
- In renal proximal tubule, multidrug resistance protein 2 (Mrp2) actively transports many organic anions into urine, including drugs and metabolic wastes. Upon exposure to nephrotoxicants or during endotoxemia, both Mrp2 ...
- Pharmacologic Specificity of Nicotinic Receptor-Mediated Relaxation of Muscarinic Receptor Precontracted Human Gastric Clasp and Sling Muscle Fibers within the Gastroesophageal Junction
[作者:Braverman, AS; Vegesna, AK; Miller, LS; Barbe, MF; Tiwana, M; Hussain, K; Ruggieri, MR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:37-46 , 文章类型: Article,,卷期:2011年338-1]
- Relaxation of gastric clasp and sling muscle fibers is involved the transient lower esophageal sphincter relaxations underlying the pathophysiology of gastroesophageal reflux disease (GERD). These fibers do not contribut...
- In Vitro and In Vivo P-Glycoprotein Transport Characteristics of Rivaroxaban
[作者:Gnoth, MJ; Buetehorn, U; Muenster, U; Schwarz, T; Sandmann, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:372-380 , 文章类型: Article,,卷期:2011年338-1]
- Rivaroxaban, an oral, direct factor Xa inhibitor, has a dual mode of elimination in humans, with two-thirds metabolized by the liver and one-third renally excreted unchanged. P-glycoprotein (P-gp) is known to be involved...
- Enhanced Sensitivity to Afferent Stimulation and Impact of Overactive Bladder Therapies in the Conscious, Spontaneously Hypertensive Rat
[作者:Patra, PB; Thorneloe, KS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:392-399 , 文章类型: Article,,卷期:2011年338-1]
- The spontaneously hypertensive rat (SHR) has been proposed as an overactive bladder model, driven, at least partially, by alterations in bladder innervation. To assess the functional role of sensory bladder afferents we ...
- Systemic Activation of the Transient Receptor Potential Vanilloid Subtype 4 Channel Causes Endothelial Failure and Circulatory Collapse: Part 2 (326, pg 443, 2008)
[作者:Willette, RN; Bao, W; Nerurkar, S; Yue, TL; Doe, CP; Stankus, G; Turner, GH; Ju, H; Thomas, H; Fishman, CE; Sulpizio, A; Behm, DJ; Hoffman, S; Lin, Z; Lozinskaya, I; Casillas, LN; Lin, M; Trout, RE; Votta, BJ; Thorneloe, K; Lashinger, ES; Figueroa, DJ; Marquis, R; Xu, X,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:408-409 , 文章类型: Correction,,卷期:2011年338-1]
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- Type 1 Diabetes-Induced Hyper-Responsiveness to 5-Hydroxytryptamine in Rat Pulmonary Arteries via Oxidative Stress and Induction of Cyclooxygenase-2
[作者:Lopez-Lopez, JG; Moral-Sanz, J; Frazziano, G; Gomez-Villalobos, MJ; Moreno, L; Menendez, C; Flores-Hernandez, J; Lorente, JA; Cogolludo, A; Perez-Vizcaino, F,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:400-407 , 文章类型: Article,,卷期:2011年338-1]
- Recent epidemiological data suggest that diabetes is a risk factor for pulmonary arterial hypertension. The aim of the present study was to analyze the link between type 1 diabetes and pulmonary arterial dysfunction in r...
- N-((1S)-1-{[4-((2S)-2-{[2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I (vol 326, pg 432, 2008)
[作者:Thorneloe, KS; Sulpizio, AC; Lin, Z; Figueroa, DJ; Clouse, AK; McCafferty, GP; Chendrimada, TP; Lashinger, ES; Gordon, E; Evans, L; Misajet, BA; DeMarini, DJ; Nation, JH; Casillas, LN; Marquis, RW; Votta, BJ; Sheardown, SA; Xu, X; Brooks, DP; Laping, NJ; Westfall, TD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:410-410 , 文章类型: Correction,,卷期:2011年338-1]
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- Rapamycin Inhibits Formation of Urethral Stricture in Rabbits
[作者:Chong, T; Fu, DL; Li, HC; Zhang, HB; Zhang, P; Gan, WM; Wang, ZM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:47-52 , 文章类型: Article,,卷期:2011年338-1]
- Rapamycin has been reported to inhibit hepatic fibrosis, lung fibrosis, renal fibrosis, and subglottic stenosis. Fibrosis is also involved in urethral stricture. Therefore, we investigated the effect of rapamycin on the ...
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