- An Activating Mutation of AKT2 and Human Hypoglycemia
[作者：Hussain, K; Challis, B; Rocha, N; Payne, F; Minic, M; Thompson, A; Daly, A; Scott, C; Harris, J; Smillie, BJL; Savage, DB; Ramaswami, U; De Lonlay, P; O'Rahilly, S; Barroso, I; Semple, RK,期刊：Science, 页码：474-474 , 文章类型： Article，,卷期：2011年334-6055]
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- Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8(+) T Cell Immunity
[作者：Epstein, JE; Tewari, K; Lyke, KE; Sim, BKL; Billingsley, PF; Laurens, MB; Gunasekera, A; Chakravarty, S; James, ER; Sedegah, M; Richman, A; Velmurugan, S; Reyes, S; Li, M; Tucker, K; Ahumada, A; Ruben, AJ; Li, T; Stafford, R; Eappen, AG; Tamminga, C; Bennett, JW; Ockenhouse, CF; Murphy, JR; Komisar, J; Thomas, N; Loyevsky, M; Birkett, A; Plowe, CV; Loucq, C; Edelman, R; Richie, TL; Seder, RA; Hoffman, SL,期刊：Science, 页码：475-480 , 文章类型： Article，,卷期：2011年334-6055]
- Our goal is to develop a vaccine that sustainably prevents Plasmodium falciparum (Pf) malaria in >= 80% of recipients. Pf sporozoites (Pf SPZ) administered by mosquito bites are the only immunogens shown to induce such p...
- Clonal Production and Organization of Inhibitory Interneurons in the Neocortex
[作者：Brown, KN; Chen, S; Han, Z; Lu, CH; Tan, X; Zhang, XJ; Ding, LY; Lopez-Cruz, A; Saur, D; Anderson, SA; Huang, K; Shi, SH,期刊：Science, 页码：480-486 , 文章类型： Article，,卷期：2011年334-6055]
- The neocortex contains excitatory neurons and inhibitory interneurons. Clones of neocortical excitatory neurons originating from the same progenitor cell are spatially organized and contribute to the formation of functio...
- Images of Asteroid 21 Lutetia: A Remnant Planetesimal from the Early Solar System
[作者：Sierks, H; Lamy, P; Barbieri, C; Koschny, D; Rickman, H; Rodrigo, R; A'Hearn, MF; Angrilli, F; Barucci, MA; Bertaux, JL; Bertini, I; Besse, S; Carry, B; Cremonese, G; Da Deppo, V; Davidsson, B; Debei, S; De Cecco, M; De Leon, J; Ferri, F; Fornasier, S; Fulle, M; Hviid, SF; Gaskell, RW; Groussin, O; Gutierrez, P; Ip, W; Jorda, L; Kaasalainen, M; Keller, HU; Knollenberg, J; Kramm, R; Kuhrt, E; Kuppers, M; Lara, L; Lazzarin, M; Leyrat, C; Moreno, JJL; Magrin, S; Marchi, S; Marzari, F; Massironi, M; Michalik, H; Moissl, R; Naletto, G; Preusker, F; Sabau, L; Sabolo, W; Scholten, F; Snodgrass, C; Thomas, N; Tubiana, C; Vernazza, P; Vincent, JB; Wenzel, KP; Andert, T; Patzold, M; Weiss, BP,期刊：Science, 页码：487-490 , 文章类型： Article，,卷期：2011年334-6055]
- Images obtained by the Optical, Spectroscopic, and Infrared Remote Imaging System (OSIRIS) cameras onboard the Rosetta spacecraft reveal that asteroid 21 Lutetia has a complex geology and one of the highest asteroid dens...
- Asteroid 21 Lutetia: Low Mass, High Density
[作者：Patzold, M; Andert, TP; Asmar, SW; Anderson, JD; Barriot, JP; Bird, MK; Hausler, B; Hahn, M; Tellmann, S; Sierks, H; Lamy, P; Weiss, BP,期刊：Science, 页码：491-492 , 文章类型： Article，,卷期：2011年334-6055]
- Asteroid 21 Lutetia was approached by the Rosetta spacecraft on 10 July 2010. The additional Doppler shift of the spacecraft radio signals imposed by 21 Lutetia's gravitational perturbation on the flyby trajectory were u...
- The Surface Composition and Temperature of Asteroid 21 Lutetia As Observed by Rosetta/VIRTIS
[作者：Coradini, A; Capaccioni, F; Erard, S; Arnold, G; De Sanctis, MC; Filacchione, G; Tosi, F; Barucci, MA; Capria, MT; Ammannito, E; Grassi, D; Piccioni, G; Giuppi, S; Bellucci, G; Benkhoff, J; Bibring, JP; Blanco, A; Blecka, M; Bockelee-Morvan, D; Carraro, F; Carlson, R; Carsenty, U; Cerroni, P; Colangeli, L; Combes, M; Combi, M; Crovisier, J; Drossart, P; Encrenaz, ET; Federico, C; Fink, U; Fonti, S; Giacomini, L; Ip, WH; Jaumann, R; Kuehrt, E; Langevin, Y; Magni, G; McCord, T; Mennella, V; Mottola, S; Neukum, G; Orofino, V; Palumbo, P; Schade, U; Schmitt, B; Taylor, F; Tiphene, D; Tozzi, G,期刊：Science, 页码：492-494 , 文章类型： Article，,卷期：2011年334-6055]
- The Visible, InfraRed, and Thermal Imaging Spectrometer (VIRTIS) on Rosetta obtained hyperspectral images, spectral reflectance maps, and temperature maps of the asteroid 21 Lutetia. No absorption features, of either sil...
- Torsional Carbon Nanotube Artificial Muscles
[作者：Foroughi, J; Spinks, GM; Wallace, GG; Oh, J; Kozlov, ME; Fang, SL; Mirfakhrai, T; Madden, JDW; Shin, MK; Kim, SJ; Baughman, RH,期刊：Science, 页码：494-497 , 文章类型： Article，,卷期：2011年334-6055]
- Rotary motors of conventional design can be rather complex and are therefore difficult to miniaturize; previous carbon nanotube artificial muscles provide contraction and bending, but not rotation. We show that an electr...
- Chemoenzymatic Synthesis of Homogeneous Ultralow Molecular Weight Heparins
[作者：Xu, YM; Masuko, S; Takieddin, M; Xu, HM; Liu, RP; Jing, J; Mousa, SA; Linhardt, RJ; Liu, J,期刊：Science, 页码：498-501 , 文章类型： Article，,卷期：2011年334-6055]
- Ultralow molecular weight (ULMW) heparins are sulfated glycans that are clinically used to treat thrombotic disorders. ULMW heparins range from 1500 to 3000 daltons, corresponding from 5 to 10 saccharide units. The comme...
- Increasing N Abundance in the Northwestern Pacific Ocean Due to Atmospheric Nitrogen Deposition
[作者：Kim, TW; Lee, K; Najjar, RG; Jeong, HD; Jeong, HJ,期刊：Science, 页码：505-509 , 文章类型： Article，,卷期：2011年334-6055]
- The relative abundance of nitrate (N) over phosphorus (P) has increased over the period since 1980 in the marginal seas bordering the northwestern Pacific Ocean, located downstream of the populated and industrialized Asi...
- Time-Critical Social Mobilization
[作者：Pickard, G; Pan, W; Rahwan, I; Cebrian, M; Crane, R; Madan, A; Pentland, A,期刊：Science, 页码：509-512 , 文章类型： Article，,卷期：2011年334-6055]
- The World Wide Web is commonly seen as a platform that can harness the collective abilities of large numbers of people to accomplish tasks with unprecedented speed, accuracy, and scale. To explore the Web's ability for s...
- The Complex Folding Network of Single Calmodulin Molecules
[作者：Stigler, J; Ziegler, F; Gieseke, A; Gebhardt, JCM; Rief, M,期刊：Science, 页码：512-516 , 文章类型： Article，,卷期：2011年334-6055]
- Direct observation of the detailed conformational fluctuations of a single protein molecule en route to its folded state has so far been realized only in silico. We have used single-molecule force spectroscopy to study t...
- How Fast-Folding Proteins Fold
[作者：Lindorff-Larsen, K; Piana, S; Dror, RO; Shaw, DE,期刊：Science, 页码：517-520 , 文章类型： Article，,卷期：2011年334-6055]
- An outstanding challenge in the field of molecular biology has been to understand the process by which proteins fold into their characteristic three-dimensional structures. Here, we report the results of atomic-level mol...
- Impacts of the Cretaceous Terrestrial Revolution and KPg Extinction on Mammal Diversification
[作者：Meredith, RW; Janecka, JE; Gatesy, J; Ryder, OA; Fisher, CA; Teeling, EC; Goodbla, A; Eizirik, E; Simao, TLL; Stadler, T; Rabosky, DL; Honeycutt, RL; Flynn, JJ; Ingram, CM; Steiner, C; Williams, TL; Robinson, TJ; Burk-Herrick, A; Westerman, M; Ayoub, NA; Springer, MS; Murphy, WJ,期刊：Science, 页码：521-524 , 文章类型： Article，,卷期：2011年334-6055]
- Previous analyses of relations, divergence times, and diversification patterns among extant mammalian families have relied on supertree methods and local molecular clocks. We constructed a molecular supermatrix for mamma...
- BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity
[作者：Shakya, R; Reid, LJ; Reczek, CR; Cole, F; Egli, D; Lin, CS; deRooij, DG; Hirsch, S; Ravi, K; Hicks, JB; Szabolcs, M; Jasin, M; Baer, R; Ludwig, T,期刊：Science, 页码：525-528 , 文章类型： Article，,卷期：2011年334-6055]
- Germline mutations of the breast cancer 1 (BRCA1) gene are a major cause of familial breast and ovarian cancer. The BRCA1 protein displays E3 ubiquitin ligase activity, and this enzymatic function is thought to be requir...
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