- Histone 3 Lysine 9 (H3K9) Methyltransferase Recruitment to the Interleukin-2 (IL-2) Promoter Is a Mechanism of Suppression of IL-2 Transcription by the Transforming Growth Factor-beta-Smad Pathway
[作者:Wakabayashi, Y; Tamiya, T; Takada, I; Fukaya, T; Sugiyama, Y; Inoue, N; Kimura, A; Morita, R; Kashiwagi, I; Takimoto, T; Nomura, M; Yoshimura, A,期刊:Journal of Biological Chemistry, 页码:35456-35465 , 文章类型: Article,,卷期:2011年286-41]
- Suppression of IL-2 beta production from T cells is an important process for the immune regulation by TGF-beta. However, the mechanism by which this suppression occurs remains to be established. Here, we demonstrate that...
- Reactive Oxygen Species and p38 Mitogen-activated Protein Kinase Mediate Tumor Necrosis Factor alpha-Converting Enzyme (TACE/ADAM-17) Activation in Primary Human Monocytes
[作者:Scott, AJ; O'Dea, KP; O'Callaghan, D; Williams, L; Dokpesi, JO; Tatton, L; Handy, JM; Hogg, PJ; Takata, M,期刊:Journal of Biological Chemistry, 页码:35466-35476 , 文章类型: Article,,卷期:2011年286-41]
- Tumor necrosis factor alpha-converting enzyme (TACE) is responsible for the shedding of cell surface TNF. Studies suggest that reactive oxygen species (ROS) mediate up-regulation of TACE activity by direct oxidization or...
- Evidence of the Proximity of ATP Synthase Subunits 6 (a) in the Inner Mitochondrial Membrane and in the Supramolecular Forms of Saccharomyces cerevisiae ATP Synthase
[作者:Velours, J; Stines-Chaumeil, C; Habersetzer, J; Chaignepain, S; Dautant, A; Brethes, D,期刊:Journal of Biological Chemistry, 页码:35477-35484 , 文章类型: Article,,卷期:2011年286-41]
- The involvement of subunit 6 (a) in the interface between yeast ATP synthase monomers has been highlighted. Based on the formation of a disulfide bond and using the unique cysteine 23 as target, we show that two subunits...
- Transcriptional Regulation of S Phase Kinase-associated Protein 2 by NR4A Orphan Nuclear Receptor NOR1 in Vascular Smooth Muscle Cells
[作者:Gizard, F; Zhao, Y; Findeisen, HM; Qing, H; Cohn, D; Heywood, EB; Jones, KL; Nomiyama, T; Bruemmer, D,期刊:Journal of Biological Chemistry, 页码:35485-35493 , 文章类型: Article,,卷期:2011年286-41]
- Members of the NR4A subgroup of the nuclear hormone receptor superfamily have emerged as key transcriptional regulators of proliferation and inflammation. NOR1 constitutes a ligand-independent transcription factor of thi...
- Taurine-containing Uridine Modifications in tRNA Anticodons Are Required to Decipher Non-universal Genetic Codes in Ascidian Mitochondria
[作者:Suzuki, T; Miyauchi, K; Suzuki, T; Yokobori, S; Shigi, N; Kondow, A; Takeuchi, N; Yamagishi, A; Watanabe, K,期刊:Journal of Biological Chemistry, 页码:35494-35498 , 文章类型: Article,,卷期:2011年286-41]
- Variations in the genetic code are found frequently in mitochondrial decoding systems. Four non-universal genetic codes are employed in ascidian mitochondria: AUA for Met, UGA for Trp, and AGA/AGG(AGR) for Gly. To clarif...
- Characterization of the Activities of the CpeY, CpeZ, and CpeS Bilin Lyases in Phycoerythrin Biosynthesis in Fremyella diplosiphon Strain UTEX 481
[作者:Biswas, A; Boutaghou, MN; Alvey, RM; Kronfel, CM; Cole, RB; Bryant, DA; Schluchter, WM,期刊:Journal of Biological Chemistry, 页码:35509-35521 , 文章类型: Article,,卷期:2011年286-41]
- When grown in green light, Fremyella diplosiphon strain UTEX 481 produces the red-colored protein phycoerythrin (PE) to maximize photosynthetic light harvesting. PE is composed of two subunits, CpeA and CpeB, which carry...
- Identification and Functional and Spectral Characterization of a Globin-coupled Histidine Kinase from Anaeromyxobacter sp Fw109-5
[作者:Kitanishi, K; Kobayashi, K; Uchida, T; Ishimori, K; Igarashi, J; Shimizu, T,期刊:Journal of Biological Chemistry, 页码:35522-35534 , 文章类型: Article,,卷期:2011年286-41]
- Two-component signal transduction systems regulate numerous important physiological functions in bacteria. In this study we have identified, cloned, overexpressed, and characterized a dimeric full-length heme-bound (heme...
- Placenta-specific Expression of the Interleukin-2 (IL-2) Receptor beta Subunit from an Endogenous Retroviral Promoter
[作者:Cohen, CJ; Rebollo, R; Babovic, S; Dai, EL; Robinson, WP; Mager, DL,期刊:Journal of Biological Chemistry, 页码:35543-35552 , 文章类型: Article,,卷期:2011年286-41]
- The long terminal repeat (LTR) sequences of endogenous retroviruses and retroelements contain promoter elements and are known to form chimeric transcripts with nearby cellular genes. Here we show that an LTR of the THE1D...
- GTP-dependent Binding and Nuclear Transport of RNA Polymerase II by Npa3 Protein
[作者:Staresincic, L; Walker, J; Dirac-Svejstrup, AB; Mitter, R; Svejstrup, JQ,期刊:Journal of Biological Chemistry, 页码:35553-35561 , 文章类型: Article,,卷期:2011年286-41]
- We identified XAB1 in a proteomic screen for factors that interact with human RNA polymerase II (RNAPII). Because XAB1 has a conserved Saccharomyces cerevisiae homologue called Npa3, yeast genetics and biochemical analys...
- ClbP Is a Prototype of a Peptidase Subgroup Involved in Biosynthesis of Nonribosomal Peptides
[作者:Dubois, D; Baron, O; Cougnoux, A; Delmas, J; Pradel, N; Boury, M; Bouchon, B; Bringer, MA; Nougayrede, JP; Oswald, E; Bonnet, R,期刊:Journal of Biological Chemistry, 页码:35562-35570 , 文章类型: Article,,卷期:2011年286-41]
- The pks genomic island of Escherichia coli encodes polyketide (PK) and nonribosomal peptide (NRP) synthases that allow assembly of a putative hybrid PK-NRP compound named colibactin that induces DNA double-strand breaks ...
- Role of Amino-terminal Half of the S4-S5 Linker in Type 1 Ryanodine Receptor (RyR1) Channel Gating
[作者:Murayama, T; Kurebayashi, N; Oba, T; Oyamada, H; Oguchi, K; Sakurai, T; Ogawa, Y,期刊:Journal of Biological Chemistry, 页码:35571-35577 , 文章类型: Article,,卷期:2011年286-41]
- The type 1 ryanodine receptor (RyR1) is a Ca(2+) release channel found in the sarcoplasmic reticulum of skeletal muscle and plays a pivotal role in excitation-contraction coupling. The RyR1 channel is activated by a conf...
- Adipocyte-specific Inactivation of Acyl-CoA Synthetase Fatty Acid Transport Protein 4 (Fatp4) in Mice Causes Adipose Hypertrophy and Alterations in Metabolism of Complex Lipids under High Fat Diet
[作者:Lenz, LS; Marx, J; Chamulitrat, W; Kaiser, I; Grone, HJ; Liebisch, G; Schmitz, G; Elsing, C; Straub, BK; Fullekrug, J; Stremmel, W; Herrmann, T,期刊:Journal of Biological Chemistry, 页码:35578-35587 , 文章类型: Article,,卷期:2011年286-41]
- Fatp4 exhibits acyl-CoA synthetase activity and is thereby able to catalyze the activation of fatty acids for further metabolism. However, its actual function in most tissues remains unresolved, and its role in cellular ...
- Inhibition of Biosynthesis of Human Endothelin B Receptor by the Cyclodepsipeptide Cotransin
[作者:Westendorf, C; Schmidt, A; Coin, I; Furkert, J; Ridelis, I; Zampatis, D; Rutz, C; Wiesner, B; Rosenthal, W; Beyermann, M; Schulein, R,期刊:Journal of Biological Chemistry, 页码:35588-35600 , 文章类型: Article,,卷期:2011年286-41]
- The specific inhibition of the biosynthesis of target proteins is a relatively novel strategy in pharmacology and is based mainly on antisense approaches (e.g. antisense oligonucleotides or RNA interference). Recently, a...
- Mechanistic Analysis of Trehalose Synthase from Mycobacterium smegmatis
[作者:Zhang, R; Pan, YT; He, SM; Lam, M; Brayer, GD; Elbein, AD; Withers, SG,期刊:Journal of Biological Chemistry, 页码:35601-35609 , 文章类型: Article,,卷期:2011年286-41]
- Trehalose synthase (TreS) catalyzes the reversible interconversion of maltose and trehalose and has been shown recently to function primarily in the mobilization of trehalose as a glycogen precursor. Consequently, the me...
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