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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共43条记录   Mice lacking microRNA 133a develop dynamin 2-dependent centronuclear myopathy [作者：Liu, N; Bezprozvannaya, S; Shelton, JM; Frisard, MI; Hulver, MW; McMillan, RP; Wu, YR; Voelker, KA; Grange, RW; Richardson, JA; Bassel-Duby, R; Olson, EN,期刊：Journal of clinical investigation, 页码：3258-3268 , 文章类型： Article，,卷期：2011年121-8] MicroRNAs modulate cellular phenotypes by inhibiting expression of mRNA targets. In this study, we have shown that the muscle-specific microRNAs miR-133a-1 and miR-133a-2 are essential for multiple facets of skeletal mus... RhoA protects the mouse heart against ischemia/reperfusion injury [作者：Xiang, SY; Vanhoutte, D; Del Re, DP; Purcell, NH; Ling, HY; Banerjee, I; Bossuyt, J; Lang, RA; Zheng, Y; Matkovich, SJ; Miyamoto, S; Molkentin, JD; Dorn, GW; Brown, JH,期刊：Journal of clinical investigation, 页码：3269-3276 , 文章类型： Article，,卷期：2011年121-8] The small GTPase RhoA serves as a nodal point for signaling through hormones and mechanical stretch. However, the role of RhoA signaling in cardiac pathophysiology is poorly understood. To address this issue, we generate... Oxidized CaMKII causes cardiac sinus node dysfunction in mice [作者：Swaminathan, PD; Purohit, A; Soni, S; Voigt, N; Singh, MV; Glukhov, AV; Gao, Z; He, BJ; Luczak, ED; Joiner, MLA; Kutschke, W; Yang, JY; Donahue, JK; Weiss, RM; Grumbach, IM; Ogawa, M; Chen, PS; Efimov, I; Dobrev, D; Mohler, PJ; Hund, TJ; Anderson, ME,期刊：Journal of clinical investigation, 页码：3277-3288 , 文章类型： Article，,卷期：2011年121-8] Sinus node dysfunction (SND) is a major public health problem that is associated with sudden cardiac death and requires surgical implantation of artificial pacemakers. However, little is known about the molecular and cel... Modulation of subthalamic T-type Ca(2+) channels remedies locomotor deficits in a rat model of Parkinson disease [作者：Tai, CH; Yang, YC; Pan, MK; Huang, CS; Kuo, CC,期刊：Journal of clinical investigation, 页码：3289-3305 , 文章类型： Article，,卷期：2011年121-8] An increase in neuronal burst activities in the subthalamic nucleus (STN) is a well-documented electrophysiological feature of Parkinson disease (PD). However, the causal relationship between subthalamic bursts and PD sy... Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease [作者：Labbadia, J; Cunliffe, H; Weiss, A; Katsyuba, E; Sathasivam, K; Seredenina, T; Woodman, B; Moussaoui, S; Frentzel, S; Luthi-Carter, R; Paganetti, P; Bates, GP,期刊：Journal of clinical investigation, 页码：3306-3319 , 文章类型： Article，,卷期：2011年121-8] Huntington disease (HD) is a devastating neurodegenerative disorder for which there are no disease-modifying treatments. Previous studies have proposed that activation of the heat shock response (HSR) via the transcripti... Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases [作者：Goldstein, DS; Holmes, C; Kopin, IJ; Sharabi, Y,期刊：Journal of clinical investigation, 页码：3320-3330 , 文章类型： Article，,卷期：2011年121-8] Several neuro&generative disorders, including Parkinson disease (PD), are characterized by the presence of Lewy bodies cytoplasmic inclusions containing a-synuclein protein aggregates in the affected neurons. A poorly un... Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents beta cell failure in rodent models of type 2 diabetes [作者：Tiano, JP; Delghingaro-Augusto, V; Le May, C; Liu, SH; Kaw, MK; Khuder, SS; Latour, MG; Bhatt, SA; Korach, KS; Najjar, SM; Prentki, M; Mauvais-Jarvis, F,期刊：Journal of clinical investigation, 页码：3331-3342 , 文章类型： Article，,卷期：2011年121-8] The failure of pancreatic beta cells to adapt to an increasing demand for insulin is the major mechanism by which patients progress from insulin resistance to type 2 diabetes (T2D) and is thought to be related to dysfunc... Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice [作者：Kodama, T; Takehara, T; Hikita, H; Shimizu, S; Shigekawa, M; Tsunematsu, H; Li, W; Miyagi, T; Hosui, A; Tatsumi, T; Ishida, H; Kanto, T; Hiramatsu, N; Kubota, S; Takigawa, M; Tomimaru, Y; Tomokuni, A; Nagano, H; Doki, Y; Mori, M; Hayashi, N,期刊：Journal of clinical investigation, 页码：3343-3356 , 文章类型： Article，,卷期：2011年121-8] The tumor suppressor p53 has been implicated in the pathogenesis of non-cancer-related conditions such as insulin resistance, cardiac failure, and early aging. In addition, accumulation of p53 has been observed in the he... 2011 American Society for Clinical Investigation Presidential Address Lost - and found - in translation [作者：Mischel, PS,期刊：Journal of clinical investigation, 页码：3357-3359 , 文章类型： Editorial Material，,卷期：2011年121-8] Integrin alpha 6 beta 4 identifies an adult distal lung epithelial population with regenerative potential in mice (vol 121, pg 2855, 2011) [作者：Chapman, HA; Li, XP; Alexander, JP; Brurnwell, A; Lorizio, W; Tan, K; Sonnenberg, A; Wei, Y; Vu, TH,期刊：Journal of clinical investigation, 页码：3360-3360 , 文章类型： Correction，,卷期：2011年121-8] Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2 (vol 121, pg 1412, 2011) [作者：Sos, BC; Harris, C; Nordstrom, SM; Tran, JL; Balazs, M; Caplazi, P; Febbraio, M; Applegate, MAB; Wagner, KU; Weiss, EJ,期刊：Journal of clinical investigation, 页码：3360-3360 , 文章类型： Correction，,卷期：2011年121-8]