- IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe(-/-) mice
[作者:Wang, J; Cheng, X; Xiang, MX; Alanne-Kinnunen, M; Wang, JA; Chen, H; He, AN; Sun, XH; Lin, Y; Tang, TT; Tu, X; Sjoberg, S; Sukhova, GK; Liao, YH; Conrad, DH; Yu, LY; Kawakami, T; Kovanen, PT; Libby, P; Shi, GP,期刊:Journal of clinical investigation, 页码:3564-3577 , 文章类型: Article,,卷期:2011年121-9]
- IgE has a key role in the pathogenesis of allergic responses through its ability to activate mast cells via the receptor Fc epsilon R1. In addition to mast cells, many cell types implicated in atherogenesis express Fc ep...
- A uroguanylin-GUCY2C endocrine axis regulates feeding in mice
[作者:Valentino, MA; Lin, JRE; Snook, AE; Li, P; Kim, GW; Marszalowicz, G; Magee, MS; Hyslop, T; Schulz, S; Waldman, SA,期刊:Journal of clinical investigation, 页码:3578-3588 , 文章类型: Article,,卷期:2011年121-9]
- Intestinal enteroendocrine cells are critical to central regulation of caloric consumption, since they activate hypothalamic circuits that decrease appetite and thereby restrict meal size by secreting hormones in respons...
- A genetically engineered human pancreatic beta cell line exhibiting glucose-inducible insulin secretion
[作者:Ravassard, P; Hazhouz, Y; Pechberty, S; Bricout-Neveu, E; Armanet, M; Czernichow, P; Scharfmann, R,期刊:Journal of clinical investigation, 页码:3589-3597 , 文章类型: Article,,卷期:2011年121-9]
- Despite intense efforts over the past 30 years, human pancreatic beta cell lines have not been available. Here, we describe a robust technology for producing a functional human beta cell line using targeted oncogenesis i...
- Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice
[作者:Wei, FY; Suzuki, T; Watanabe, S; Kimura, S; Kaitsuka, T; Fujimura, A; Matsui, H; Atta, M; Michiue, H; Fontecave, M; Yamagata, K; Suzuki, T; Tomizawa, K,期刊:Journal of clinical investigation, 页码:3598-3608 , 文章类型: Article,,卷期:2011年121-9]
- The worldwide prevalence of type 2 diabetes (T2D), which is caused by a combination of environmental and genetic factors, is increasing. With regard to genetic factors, variations in the gene encoding Cdk5 regulatory ass...
- Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity
[作者:Mamessier, E; Sylvain, A; Thibult, ML; Houvenaeghel, G; Jacquemier, J; Castellano, R; Goncalves, A; Andre, P; Romagne, F; Thibault, G; Viens, P; Birnbaum, D; Bertucci, F; Moretta, A; Olive, D,期刊:Journal of clinical investigation, 页码:3609-3622 , 文章类型: Article,,卷期:2011年121-9]
- NK cells are a major component of the antitumor immune response and are involved in controlling tumor progression and metastases in animal models. Here, we show that dysfunction of these cells accompanies human breast tu...
- Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator
[作者:Shuda, M; Kwun, HJ; Feng, HC; Chang, Y; Moore, PS,期刊:Journal of clinical investigation, 页码:3623-3634 , 文章类型: Article,,卷期:2011年121-9]
- Merkel cell polyomavirus (MCV) is the recently discovered cause of most Merkel cell carcinomas (MCCs), an aggressive form of nonmelanoma skin cancer. Although MCV is known to integrate into the tumor cell genome and to u...
- The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans
[作者:Menard, L; Saadoun, D; Isnardi, I; Ng, YS; Meyers, G; Massad, C; Price, C; Abraham, C; Motaghedi, R; Buckner, JH; Gregersen, PK; Meffre, E,期刊:Journal of clinical investigation, 页码:3635-3644 , 文章类型: Article,,卷期:2011年121-9]
- Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene polymorphisms are associated with many autoimmune diseases. The major risk allele encodes an R620W amino acid change that alters B cell receptor (BCR) signal...
- Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice
[作者:Ding, Q; Yeung, M; Camirand, G; Zeng, Q; Akiba, H; Yagita, H; Chalasani, G; Sayegh, MH; Najafian, N; Rothstein, DM,期刊:Journal of clinical investigation, 页码:3645-3656 , 文章类型: Article,,卷期:2011年121-9]
- T cell Ig domain and mucin domain protein 1 (TIM-1) is a costimulatory molecule that regulates immune responses by modulating CD4(+) T cell effector differentiation. However, the function of TIM-1 on other immune cell po...
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