- A nucleolar protein, H19 opposite tumor suppressor (HOTS), is a tumor growth inhibitor encoded by a human imprinted H19 antisense transcript
[作者:Onyango, P; Feinberg, AP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16759-16764 , 文章类型: Article,,卷期:2011年108-40]
- The H19 gene, which localizes within a chromosomal region on human chromosome 11p15 that is commonly lost in Wilms tumor (WT), encodes an imprinted untranslated RNA. However, the biological significance of the H19 noncod...
- Isovaleryl-homoserine lactone, an unusual branched-chain quorum-sensing signal from the soybean symbiont Bradyrhizobium japonicum
[作者:Lindemann, A; Pessi, G; Schaefer, AL; Mattmann, ME; Christensen, QH; Kessler, A; Hennecke, H; Blackwell, HE; Greenberg, EP; Harwood, CS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16765-16770 , 文章类型: Article,,卷期:2011年108-40]
- Many species of Proteobacteria communicate by using LuxI-LuxR-type quorum-sensing systems that produce and detect acyl-homoserine lactone (acyl-HSL) signals. Most of the known signals are straight-chain fatty acyl-HSLs, ...
- Thaumarchaeotes abundant in refinery nitrifying sludges express amoA but are not obligate autotrophic ammonia oxidizers
[作者:Mussmann, M; Brito, I; Pitcher, A; Damste, JSS; Hatzenpichler, R; Richter, A; Nielsen, JL; Nielsen, PH; Muller, A; Daims, H; Wagner, M; Head, IM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16771-16776 , 文章类型: Article,,卷期:2011年108-40]
- Nitrification is a core process in the global nitrogen cycle that is essential for the functioning of many ecosystems. The discovery of autotrophic ammonia-oxidizing archaea (AOA) within the phylum Thaumarchaeota has cha...
- A virus capsid component mediates virion retention and transmission by its insect vector
[作者:Chen, AYS; Walker, GP; Carter, D; Ng, JCK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16777-16782 , 文章类型: Article,,卷期:2011年108-40]
- Numerous pathogens of humans, animals, and plants are transmitted by specific arthropod vectors. However, understanding the mechanisms governing these pathogen-vector interactions is hampered, in part, by the lack of eas...
- Investigating the electrophysiological basis of resting state networks using magnetoencephalography
[作者:Brookes, MJ; Woolrich, M; Luckhoo, H; Price, D; Hale, JR; Stephenson, MC; Barnes, GR; Smith, SM; Morris, PG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16783-16788 , 文章类型: Article,,卷期:2011年108-40]
- In recent years the study of resting state brain networks (RSNs) has become an important area of neuroimaging. The majority of studies have used functional magnetic resonance imaging (fMRI) to measure temporal correlatio...
- Repressor element 1 silencing transcription factor (REST) controls radial migration and temporal neuronal specification during neocortical development
[作者:Mandel, G; Fiondella, CG; Covey, MV; Lu, DD; LoTurco, JJ; Ballas, N,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16789-16794 , 文章类型: Article,,卷期:2011年108-40]
- Neurogenesis requires mechanisms that coordinate early cell-fate decisions, migration, and terminal differentiation. Here, we show that the transcriptional repressor, repressor element 1 silencing transcription factor (R...
- Pathogenic polyglutamine proteins cause dendrite defects associated with specific actin cytoskeletal alterations in Drosophila
[作者:Lee, SB; Bagley, JA; Lee, HY; Jan, LY; Jan, YN,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16795-16800 , 文章类型: Article,,卷期:2011年108-40]
- Whereas the neurodegeneration associated with various polyglutamine (polyQ) diseases has prompted extensive studies of polyQ-induced cell death, the neuronal loss that typically appears during late stages of the diseases...
- Habit learning is associated with major shifts in frequencies of oscillatory activity and synchronized spike firing in striatum
[作者:Howe, MW; Atallah, HE; McCool, A; Gibson, DJ; Graybiel, AM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16801-16806 , 文章类型: Article,,卷期:2011年108-40]
- Rhythmic brain activity is thought to reflect, and to help organize, spike activity in populations of neurons during on-going behavior. We report that during learning, a major transition occurs in task-related oscillator...
- Inhibitory interneurons in a cortical column form hot zones of inhibition in layers 2 and 5A
[作者:Meyer, HS; Schwarz, D; Wimmer, VC; Schmitt, AC; Kerr, JND; Sakmann, B; Helmstaedter, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16807-16812 , 文章类型: Article,,卷期:2011年108-40]
- Although physiological data on microcircuits involving a few inhibitory neurons in the mammalian cerebral cortex are available, data on the quantitative relation between inhibition and excitation in cortical circuits inv...
- Human sweet taste receptor mediates acid-induced sweetness of miraculin
[作者:Koizumi, A; Tsuchiya, A; Nakajima, K; Ito, K; Terada, T; Shimizu-Ibuka, A; Briand, L; Asakura, T; Misaka, T; Abe, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16819-16824 , 文章类型: Article,,卷期:2011年108-40]
- Miraculin (MCL) is a homodimeric protein isolated from the red berries of Richadella dulcifica. MCL, although flat in taste at neutral pH, has taste-modifying activity to convert sour stimuli to sweetness. Once MCL is he...
- Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice
[作者:Nori, S; Okada, Y; Yasuda, A; Tsuji, O; Takahashi, Y; Kobayashi, Y; Fujiyoshi, K; Koike, M; Uchiyama, Y; Ikeda, E; Toyama, Y; Yamanaka, S; Nakamura, M; Okano, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16825-16830 , 文章类型: Article,,卷期:2011年108-40]
- Once their safety is confirmed, human-induced pluripotent stem cells (hiPSCs), which do not entail ethical concerns, may become a preferred cell source for regenerative medicine. Here, we investigated the therapeutic pot...
- Lotus japonicus nodulation is photomorphogenetically controlled by sensing the red/far red (R/FR) ratio through jasmonic acid (JA) signaling
[作者:Suzuki, A; Suriyagoda, L; Shigeyama, T; Tominaga, A; Sasaki, M; Hiratsuka, Y; Yoshinaga, A; Arima, S; Agarie, S; Sakai, T; Inada, S; Jikumaru, Y; Kamiya, Y; Uchiumi, T; Abe, M; Hashiguchi, M; Akashi, R; Sato, S; Kaneko, T; Tabata, S; Hirsch, AM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16837-16842 , 文章类型: Article,,卷期:2011年108-40]
- Light is critical for supplying carbon to the energetically expensive, nitrogen-fixing symbiosis between legumes and rhizobia. Here, we show that phytochrome B (phyB) is part of the monitoring system to detect suboptimal...
- HSP90 functions in the circadian clock through stabilization of the client F-box protein ZEITLUPE
[作者:Kim, TS; Kim, WY; Fujiwara, S; Kim, J; Cha, JY; Park, JH; Lee, SY; Somers, DE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16843-16848 , 文章类型: Article,,卷期:2011年108-40]
- The autoregulatory loops of the circadian clock consist of feedback regulation of transcription/translation circuits but also require finely coordinated cytoplasmic and nuclear proteostasis. Although protein degradation ...
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