- The Tryptophan Hydroxylase Inhibitor LX1031 Shows Clinical Benefit in Patients With Nonconstipating Irritable Bowel Syndrome
[作者：Brown, PM; Drossman, DA; Wood, AJJ; Cline, GA; Frazier, KS; Jackson, JI; Bronner, J; Freiman, J; Zambrowicz, B; Sands, A; Gershon, MD,期刊：Gastroenterology, 页码：507-516 , 文章类型： Article，,卷期：2011年141-2]
- BACKGROUND & AIMS: Serotonin (5-hydroxytryptamine [5-HT]) has an important role in gastrointestinal function. LX1031 is an oral, locally acting, small molecule inhibitor of tryptophan hydroxylase (TPH). Local inhibition ...
- Serum Hepatitis B Surface Antigen Levels Predict Surface Antigen Loss in Hepatitis B e Antigen Seroconverters
[作者：Tseng, TC; Liu, CJ; Su, TH; Wang, CC; Chen, CL; Chen, PJ; Chen, DS; Kao, JH,期刊：Gastroenterology, 页码：517-U600 , 文章类型： Article，,卷期：2011年141-2]
- BACKGROUND & AIMS: Loss of hepatitis B surface antigen (HBsAg) usually indicates that hepatitis B virus (HBV) infection has been cured. However, little is known about factors predicting HBsAg loss in patients who spontan...
- Radiographic Response to Locoregional Therapy in Hepatocellular Carcinoma Predicts Patient Survival Times
[作者：Memon, K; Kulik, L; Lewandowski, RJ; Wang, E; Riaz, A; Ryu, RK; Sato, KT; Marshall, K; Gupta, R; Nikolaidis, P; Miller, FH; Yaghmai, V; Senthilnathan, S; Baker, T; Gates, VL; Abecassis, M; Benson, AB; Mulcahy, MF; Omary, RA; Salem, R,期刊：Gastroenterology, 页码：526-U612 , 文章类型： Article，,卷期：2011年141-2]
- BACKGROUND & AIMS: It is not clear whether survival times of patients with hepatocellular carcinoma (HCC) are associated with their response to therapy. We analyzed the association between tumor response and survival tim...
- Pregabalin Reduces Pain in Patients With Chronic Pancreatitis in a Randomized, Controlled Trial
[作者：Olesen, SS; Bouwense, SAW; Wilder-Smith, OHG; van Goor, H; Drewes, AM,期刊：Gastroenterology, 页码：536-543 , 文章类型： Article，,卷期：2011年141-2]
- BACKGROUND & AIMS: Pain is a disabling symptom for patients with chronic pancreatitis (CP) and difficult to treat. Evidence from basic science and human studies indicates that pain processing by the central nervous syste...
- Neuronal Plasticity in the Cingulate Cortex of Rats Following Esophageal Acid Exposure in Early Life
[作者：Banerjee, B; Medda, BK; Schmidt, J; Lang, IM; Sengupta, JN; Shaker, R,期刊：Gastroenterology, 页码：544-552 , 文章类型： Article，,卷期：2011年141-2]
- BACKGROUND & AIMS: The cingulate cortex has been reported to be involved in processing pain of esophageal origin. However, little is known about molecular changes and cortical activation that arise from early-life esopha...
- beta-Catenin and p120 Mediate PPAR delta-Dependent Proliferation Induced by Helicobacter pylori in Human and Rodent Epithelia
[作者：Nagy, TA; Wroblewski, LE; Wang, DZ; Piazuelo, MB; Delgado, A; Romero-Gallo, J; Noto, J; Israel, DA; Ogden, SR; Correa, P; Cover, TL; Peek, RM,期刊：Gastroenterology, 页码：553-564 , 文章类型： Article，,卷期：2011年141-2]
- BACKGROUND & AIMS: Colonization of gastric mucosa by Helicobacter pylori leads to epithelial hyperproliferation, which increases the risk for gastric adenocarcinoma. One H pylori virulence locus associated with cancer ri...
- Transient Receptor Potential Ankyrin 1 Is Expressed by Inhibitory Motoneurons of the Mouse Intestine
[作者：Poole, DP; Pelayo, JC; Cattaruzza, F; Kuo, YM; Gai, G; Chiu, JV; Bron, R; Furness, JB; Grady, EF; Bunnett, NW,期刊：Gastroenterology, 页码：565-U656 , 文章类型： Article，,卷期：2011年141-2]
- BACKGROUND & AIMS: Transient receptor potential ankyrin (TRPA) 1, an excitatory ion channel expressed by sensory neurons, mediates somatic and visceral pain in response to direct activation or noxious mechanical stimulat...
- Expression Level of Hand2 Affects Specification of Enteric Neurons and Gastrointestinal Function in Mice
[作者：D'Autreaux, F; Margolis, KG; Roberts, J; Stevanovic, K; Mawe, G; Li, ZS; Karamooz, N; Ahuja, A; Morikawa, Y; Cserjesi, P; Setlick, W; Gershon, MD,期刊：Gastroenterology, 页码：576-U674 , 文章类型： Article，,卷期：2011年141-2]
- BACKGROUND & AIMS: Hand2 is a basic helix-loop-helix transcription factor required for terminal differentiation of enteric neurons. We studied Hand2 haploinsufficient mice, to determine whether reduced expression of Hand...
- Enteric Neuronal Density Contributes to the Severity of Intestinal Inflammation
[作者：Margolis, KG; Stevanovic, K; Karamooz, N; Li, ZS; Ahuja, A; D'Autreaux, F; Saurman, V; Chalazonitis, A; Gershon, MD,期刊：Gastroenterology, 页码：588-U687 , 文章类型： Article，,卷期：2011年141-2]
- BACKGROUND & AIMS: Enteric neurons have been reported to be increased in inflamed regions of the bowel in patients with inflammatory bowel disease or intestinal neurogangliomatosis. It is impossible to determine whether ...
- Single Nucleotide Polymorphisms That Increase Expression of the Guanosine Triphosphatase RAC1 Are Associated With Ulcerative Colitis
[作者：Muise, AM; Walters, T; Xu, W; Shen-Tu, G; Guo, CH; Fattouh, R; Lam, GY; Wolters, VM; Bennitz, J; van Limbergen, J; Renbaum, P; Kasirer, Y; Ngan, BY; Turner, D; Denson, LA; Sherman, PM; Duerr, RH; Cho, J; Lees, CW; Satsangi, J; Wilson, DC; Paterson, AD; Griffiths, AM; Glogauer, M; Silverberg, MS; Brumell, JH,期刊：Gastroenterology, 页码：633-641 , 文章类型： Article，,卷期：2011年141-2]
- BACKGROUND & AIMS: RAC1 is a guanosine triphosphatase that has an evolutionarily conserved role in coordinating immune defenses, from plants to mammals. Chronic inflammatory bowel diseases are associated with dysregulati...
- Mycobacterium bovis Bacillus Calmette-Guerin Killed by Extended Freeze-Drying Reduces Colitis in Mice
[作者：Lagranderie, M; Kluge, C; Kiefer-Biasizzo, H; Abolhassani, M; Nahori, MA; Fitting, C; Huerre, M; Bandeira, A; Bercovier, H; Marchal, G,期刊：Gastroenterology, 页码：642-U750 , 文章类型： Article，,卷期：2011年141-2]
- BACKGROUND & AIMS: Mycobacterium bovis Bacillus Calmette-Guerin (BCG), killed by extended freeze-drying (EFD), induces secretion of interleukin-10 and reduces lung inflammation in a mouse model of asthma. We investigated...
- Antigen-Presenting Cell Production of IL-10 Inhibits T-Helper 1 and 17 Cell Responses and Suppresses Colitis in Mice
[作者：Liu, B; Tonkonogy, SL; Sartor, RB,期刊：Gastroenterology, 页码：653-U764 , 文章类型： Article，,卷期：2011年141-2]
- BACKGROUND & AIMS: Mice that are deficient in interleukin (IL)-10 develop colitis, mediated by T-helper (Th)1 and Th17 cells, and IL-10-producing regulatory T (Treg) cells suppress colitis, implicating IL-10 in maintaini...
- Oxaliplatin Sensitizes Human Colon Cancer Cells to TRAIL Through JNK-Dependent Phosphorylation of Bcl-xL
[作者：El Fajoui, Z; Toscano, F; Jacquemin, G; Abello, J; Scoazec, JY; Micheau, O; Saurin, JC,期刊：Gastroenterology, 页码：663-673 , 文章类型： Article，,卷期：2011年141-2]
- BACKGROUND & AIMS: Oxaliplatin sensitizes drug-resistant colon cancer cell lines to tumor necrosis factor-related apoptosis inducing ligand (TRAIL), a death receptor ligand that is selective for cancer cells. We investig...
- Differential, Type I Interferon-Mediated Autophagic Trafficking of Hepatitis C Virus Proteins in Mouse Liver
[作者：Desai, MM; Gong, B; Chan, TS; Davey, RA; Soong, L; Kolokoltsov, AA; Sun, JR,期刊：Gastroenterology, 页码：674-U793 , 文章类型： Article，,卷期：2011年141-2]
- BACKGROUND & AIMS: The hepatitis C virus (HCV) serine protease NS3/4A can cleave mitochondria-associated antiviral signaling protein (MAVS) and block retinoic acid-inducible gene I-mediated interferon (IFN) responses. Al...
- Delayed Induction, Not Impaired Recruitment, of Specific CD8(+) T Cells Causes the Late Onset of Acute Hepatitis C
[作者：Shin, EC; Park, SH; Demino, M; Nascimbeni, M; Mihalik, K; Major, M; Veerapu, NS; Heller, T; Feinstone, SM; Rice, CM; Rehermann, B,期刊：Gastroenterology, 页码：686-U804 , 文章类型： Article，,卷期：2011年141-2]
- BACKGROUND & AIMS: Hepatitis C virus (HCV) infection is characterized by lack of immune-mediated liver injury despite a high level of HCV replication during the incubation phase, which lasts about 8 weeks. We investigate...
- 5 ' Triphosphorylated Small Interfering RNAs Control Replication of Hepatitis B Virus and Induce an Interferon Response in Human Liver Cells and Mice
[作者：Ebert, G; Poeck, H; Lucifora, J; Baschuk, N; Esser, K; Esposito, I; Hartmann, G; Protzer, U,期刊：Gastroenterology, 页码：696-U818 , 文章类型： Article，,卷期：2011年141-2]
- BACKGROUND & AIMS: Approved therapies for chronic hepatitis B include systemic administration of interferon (IFN)-alfa and inhibitors of hepatitis B virus (HBV) reverse-transcription. Systemic application of IFN-alfa is ...
|