- Stromal Regulation of Human Gastric Dendritic Cells Restricts the Th1 Response to Helicobacter pylori
[作者:Bimczok, D; Grams, JM; Stahl, RD; Waites, KB; Smythies, LE; Smith, PD,期刊:Gastroenterology, 页码:929-938 , 文章类型: Article,,卷期:2011年141-3]
- BACKGROUND & AIMS: Mucosal dendritic cells (DCs) play a key role in initiating the T-helper (Th)1 response to Helicobacter pylori. To further elucidate the mucosal response to H pylori, we examined whether gastric stroma...
- Sleeve Gastrectomy in Rats Improves Postprandial Lipid Clearance by Reducing Intestinal Triglyceride Secretion
[作者:Stefater, MA; Sandoval, DA; Chambers, AP; Wilson-Perez, HE; Hofmann, SM; Jandacek, R; Tso, P; Woods, SC; Seeley, RJ,期刊:Gastroenterology, 页码:939-U675 , 文章类型: Article,,卷期:2011年141-3]
- BACKGROUND & AIMS: Postprandial hyperlipidemia is risk factor for atherosclerotic heart disease and is associated with the consumption of high-fat diets and obesity. Bariatric surgeries result in superior and more durabl...
- Weight-Independent Changes in Blood Glucose Homeostasis After Gastric Bypass or Vertical Sleeve Gastrectomy in Rats
[作者:Chambers, AP; Jessen, L; Ryan, KK; Sisley, S; Wilson-Perez, HE; Stefater, MA; Gaitonde, SG; Sorrell, JE; Toure, M; Berger, J; D'Alessio, DA; Woods, SC; Seeley, RJ; Sandoval, DA,期刊:Gastroenterology, 页码:950-958 , 文章类型: Article,,卷期:2011年141-3]
- BACKGROUND & AIMS: Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) reduce weight and improve glucose metabolism in obese patients, although it is not clear if metabolic changes are independent of we...
- Enterococcus faecalis Metalloprotease Compromises Epithelial Barrier and Contributes to Intestinal Inflammation
[作者:Steck, N; Hoffmann, M; Sava, IG; Kim, SC; Hahne, H; Tonkonogy, SL; Mair, K; Krueger, D; Pruteanu, M; Shanahan, F; Vogelmann, R; Schemann, M; Kuster, B; Sartor, RB; Haller, D,期刊:Gastroenterology, 页码:959-971 , 文章类型: Article,,卷期:2011年141-3]
- BACKGROUND & AIMS: Matrix metalloproteases (MMPs) mediate pathogenesis of chronic intestinal inflammation. We characterized the role of the gelatinase (GelE), a metalloprotease from Enterococcus faecalis, in the developm...
- TLE1 Modifies the Effects of NOD2 in the Pathogenesis of Crohn's Disease
[作者:Nimmo, ER; Stevens, C; Phillips, AM; Smith, A; Drummond, HE; Noble, CL; Quail, M; Davies, G; Aldhous, MC; Wilson, DC; Satsangi, J,期刊:Gastroenterology, 页码:972-U677 , 文章类型: Article,,卷期:2011年141-3]
- BACKGROUND & AIMS: The mechanisms by which specific mutations in NOD2/CARD15 increase the risk for Crohn's disease (CD) are unclear. We identified proteins that interact with NOD2 and investigated them by expression, gen...
- Localization and Regulation of Fluorescently Labeled Delta Opioid Receptor, Expressed in Enteric Neurons of Mice
[作者:Poole, DP; Pelayo, JC; Scherrer, G; Evans, CJ; Kieffer, BL; Bunnett, NW,期刊:Gastroenterology, 页码:982-U695 , 文章类型: Article,,卷期:2011年141-3]
- BACKGROUND & AIMS: Opioids and opiates inhibit gastrointestinal functions via mu, delta, and kappa receptors. Although agonists of the delta opioid receptor (DOR) suppress motility and secretion, little is known about th...
- Analysis of the Sacral Neural Crest Cell Contribution to the Hindgut Enteric Nervous System in the Mouse Embryo
[作者:Wang, X; Chan, AKK; Sham, MH; Burns, AJ; Chan, WY,期刊:Gastroenterology, 页码:992-U712 , 文章类型: Article,,卷期:2011年141-3]
- BACKGROUND & AIMS: The majority of the enteric nervous system is derived from the vagal neural crest, with a second contribution, which is restricted to the post-umbilical gut, originating from the sacral neural crest. I...
- Mutant Kras Promotes Hyperplasia and Alters Differentiation in the Colon Epithelium but Does Not Expand the Presumptive Stem Cell Pool
[作者:Feng, Y; Bommer, GT; Zhao, J; Green, M; Sands, E; Zhai, Y; Brown, K; Burberry, A; Cho, KR; Fearon, ER,期刊:Gastroenterology, 页码:1003-U733 , 文章类型: Article,,卷期:2011年141-3]
- BACKGROUND & AIMS: Adenomatous polyps are precursors to colorectal cancer (CRC), whereas hyperplastic polyps (HPPs) have low risk of progression to CRC. Mutations in KRAS are found in similar to 40% of CRCs and large ade...
- Regulatory T Cells Suppress Development of Colitis, Blocking Differentiation of T-Helper 17 Into Alternative T-Helper 1 Cells
[作者:Sujino, T; Kanai, T; Ono, Y; Mikami, Y; Hayashi, A; Doi, T; Matsuoka, K; Hisamatsu, T; Takaishi, H; Ogata, H; Yoshimura, A; Littman, DR; Hibi, T,期刊:Gastroenterology, 页码:1014-1023 , 文章类型: Article,,卷期:2011年141-3]
- BACKGROUND & AIMS: Although T-helper (Th) 17 and Th1 cells are involved in pathogenesis of intestinal inflammation, their developmental pathways and sufficiency to promote disease are not known; nor are the roles of CD4(...
- Altered Endoplasmic Reticulum Stress Affects Translation in Inactive Colon Tissue From Patients With Ulcerative Colitis
[作者:Treton, X; Pedruzzi, E; Cazals-Hatem, D; Grodet, A; Panis, Y; Groyer, A; Moreau, R; Bouhnik, Y; Daniel, F; Ogier-Denis, E,期刊:Gastroenterology, 页码:1024-1035 , 文章类型: Article,,卷期:2011年141-3]
- BACKGROUND & AIMS: Ulcerative colitis (UC) is a chronic inflammatory disorder that affects the colonic epithelium. Epidemiology studies indicate an environmental component is involved in pathogenesis, although the primar...
- p53 and PUMA Independently Regulate Apoptosis of Intestinal Epithelial Cells in Patients and Mice With Colitis
[作者:Dirisina, R; Katzman, RB; Goretsky, T; Managlia, E; Mittal, N; Williams, DB; Qiu, W; Yu, J; Chandel, NS; Zhang, L; Barrett, TA,期刊:Gastroenterology, 页码:1036-1045 , 文章类型: Article,,卷期:2011年141-3]
- BACKGROUND & AIMS: Inflammatory bowel disease (IBD) is associated with increased apoptosis of intestinal epithelial cells (IECs). Mutations in the tumor suppressor p53 appear during early stages of progression from colit...
- Mesenchymal Stem Cells Promote Formation of Colorectal Tumors in Mice
[作者:Tsai, KS; Yang, SH; Lei, YP; Tsai, CC; Chen, HW; Hsu, CY; Chen, LL; Wang, HW; Miller, SA; Chiou, SH; Hung, MC; Hung, SC,期刊:Gastroenterology, 页码:1046-1056 , 文章类型: Article,,卷期:2011年141-3]
- BACKGROUND & AIMS: Tumor-initiating cells are a subset of tumor cells with the ability to form new tumors; however, they account for less than 0.001% of the cells in colorectal or other types of tumors. Mesenchymal stem ...
- Mouse Hepatic Cells Support Assembly of Infectious Hepatitis C Virus Particles
[作者:Long, G; Hiet, MS; Windisch, MP; Lee, JY; Lohmann, V; Bartenschlager, R,期刊:Gastroenterology, 页码:1057-1066 , 文章类型: Article,,卷期:2011年141-3]
- BACKGROUND & AIMS: Hepatitis C virus (HCV) has a high propensity to establish persistence; better understanding of this process requires the development of a fully permissive and immunocompetent small animal model. Mouse...
- Differential Efficacy of Protease Inhibitors Against HCV Genotypes 2a, 3a, 5a, and 6a NS3/4A Protease Recombinant Viruses
[作者:Gottwein, JM; Scheel, TKH; Jensen, TB; Ghanem, L; Bukh, J,期刊:Gastroenterology, 页码:1067-1079 , 文章类型: Article,,卷期:2011年141-3]
- BACKGROUND & AIMS: The hepatitis C virus (HCV) genotype influences efficacy of interferon (IFN)-based therapy. HCV protease inhibitors are being licensed for treatment of genotype 1 infection. Because there are limited o...
- Cross beta-Sheet Conformation of Keratin 8 Is a Specific Feature of Mallory-Denk Bodies Compared With Other Hepatocyte Inclusions
[作者:Mahajan, V; Klingstedt, T; Simon, R; Nilsson, KPR; Thueringer, A; Kashofer, K; Haybaeck, J; Denk, H; Abuja, PM; Zatloukal, K,期刊:Gastroenterology, 页码:1080-U428 , 文章类型: Article,,卷期:2011年141-3]
- BACKGROUND & AIMS: Mallory-Denk bodies (MDBs) are cytoplasmic protein aggregates in hepatocytes in steato-hepatitis and other liver diseases. We investigated the molecular structure of keratin 8 (K8) and 18 (K18), seques...
- Deletion of Rb Accelerates Pancreatic Carcinogenesis by Oncogenic Kras and Impairs Senescence in Premalignant Lesions
[作者:Carriere, C; Gore, AJ; Norris, AM; Gunn, JR; Young, AL; Longnecker, DS; Korc, M,期刊:Gastroenterology, 页码:1091-1101 , 文章类型: Article,,卷期:2011年141-3]
- BACKGROUND & AIMS: Rb1 encodes a cell-cycle regulator that is functionally disrupted in most human cancers. Pancreatic ductal adenocarcinomas (PDACs) have a high frequency of mutations in KRAS and INK4A/CDKN2A that might...
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