- A Klotho beta Variant Mediates Protein Stability and Associates With Colon Transit in Irritable Bowel Syndrome With Diarrhea
[作者：Wong, BS; Camilleri, M; Carlson, PJ; Guicciardi, ME; Burton, D; McKinzie, S; Rao, AS; Zinsmeister, AR; Gores, GJ,期刊：Gastroenterology, 页码：1934-1942 , 文章类型： Article，,卷期：2011年140-7]
- BACKGROUND & AIMS: Bile acid (BA) malabsorption of moderate severity is reported in 32% of patients with chronic unexplained diarrhea, including diarrhea-predominant irritable bowel syndrome (IBS-D). We hypothesized that...
- The HTR3A Polymorphism c.-42C > T Is Associated With Amygdala Responsiveness in Patients With Irritable Bowel Syndrome
[作者：Kilpatrick, LA; Labus, JS; Coveleskie, K; Hammer, C; Rappold, G; Tillisch, K; Bueller, JA; Suyenobu, B; Jarcho, JM; McRoberts, JA; Niesler, B; Mayer, EA,期刊：Gastroenterology, 页码：1943-1951 , 文章类型： Article，,卷期：2011年140-7]
- BACKGROUND & AIMS: 5-Hydroxytryptamine (5-HT) 3 receptor (5-HT3R) antagonists are effective in treating patients with irritable bowel syndrome (IBS) and have anxiolytic effects. Their therapeutic effects are related, in ...
- A Revised Model for End-Stage Liver Disease Optimizes Prediction of Mortality Among Patients Awaiting Liver Transplantation
[作者：Leise, MD; Kim, WR; Kremers, WK; Larson, JJ; Benson, JT; Therneau, TM,期刊：Gastroenterology, 页码：1952-1960 , 文章类型： Article，,卷期：2011年140-7]
- BACKGROUND & AIMS: The Model for End Stage Liver Disease (MELD) was originally developed based on data from patients who underwent the transjugular intrahepatic portosystemic shunt procedure. An updated MELD based on dat...
- Coffee Consumption Is Associated With Response to Peginterferon and Ribavirin Therapy in Patients With Chronic Hepatitis C
[作者：Freedman, ND; Curto, TM; Lindsay, KL; Wright, EC; Sinha, R; Everhart, JE,期刊：Gastroenterology, 页码：1961-1969 , 文章类型： Article，,卷期：2011年140-7]
- BACKGROUND & AIMS: High-level coffee consumption has been associated with reduced progression of pre-existing liver diseases and lower risk of hepatocellular carcinoma. However, its relationship with therapy for hepatiti...
- Noninvasive Tests for Fibrosis and Liver Stiffness Predict 5-Year Outcomes of Patients With Chronic Hepatitis C
[作者：Vergniol, J; Foucher, J; Terrebonne, E; Bernard, PH; le Bail, B; Merrouche, W; Couzigou, P; de Ledinghen, V,期刊：Gastroenterology, 页码：1970-U197 , 文章类型： Article，,卷期：2011年140-7]
- BACKGROUND & AIMS: Liver stiffness can be measured noninvasively to assess liver fibrosis in patients with chronic hepatitis C. In patients with chronic liver diseases, level of fibrosis predicts liver-related complicati...
- Long-term Outcomes of Patients With Autoimmune Hepatitis Managed at a Nontransplant Center
[作者：Hoeroldt, B; McFarlane, E; Dube, A; Basumani, P; Karajeh, M; Campbell, MJ; Gleeson, D,期刊：Gastroenterology, 页码：1980-1989 , 文章类型： Article，,卷期：2011年140-7]
- BACKGROUND & AIMS: The long-term outcomes of patients treated for autoimmune hepatitis (AIH) are considered to be good. However, follow-up data beyond 10 years are limited and confined to tertiary referral centers. We as...
- Maintenance Therapy With Peginterferon Alfa-2b Does Not Prevent Hepatocellular Carcinoma in Cirrhotic Patients With Chronic Hepatitis C
[作者：Bruix, J; Poynard, T; Colombo, M; Schiff, E; Burak, K; Heathcote, EJL; Berg, T; Poo, JL; Mello, CB; Guenther, R; Niederau, C; Terg, R; Bedossa, P; Boparai, N; Griffel, LH; Burroughs, M; Brass, CA; Albrecht, JK,期刊：Gastroenterology, 页码：1990-1999 , 文章类型： Article，,卷期：2011年140-7]
- BACKGROUND & AIMS: Several studies have reported that low doses of interferon can delay the development of hepatocellular carcinoma (HCC) and progression of chronic hepatitis C. We investigated the incidence of clinical ...
- Loss of Adiponectin Promotes Intestinal Carcinogenesis in Min and Wild-type Mice
[作者：Mutoh, M; Teraoka, N; Takasu, S; Takahashi, M; Onuma, K; Yamamoto, M; Kubota, N; Iseki, T; Kadowaki, T; Sugimura, T; Wakabayashi, K,期刊：Gastroenterology, 页码：2000-U228 , 文章类型： Article，,卷期：2011年140-7]
- BACKGROUND & AIMS: Metabolic syndrome- and obesity-associated cancers, including colon cancer, are common in Western countries. Visceral fat accumulation and decreased levels of plasma adiponectin (APN) have been associa...
- S-Nitrosylation of the Death Receptor Fas Promotes Fas Ligand-Mediated Apoptosis in Cancer Cells
[作者：Leon-Bollotte, L; Subramaniam, S; Cauvard, O; Plenchette-Colas, S; Paul, C; Godard, C; Martinez-Ruiz, A; Legembre, P; Jeannin, JF; Bettaieb, A,期刊：Gastroenterology, 页码：2009-U242 , 文章类型： Article，,卷期：2011年140-7]
- BACKGROUND & AIMS: Fas belongs to the family of tumor necrosis factor receptors which induce apoptosis. Many cancer cells express Fas but do not undergo Fas-mediated apoptosis. Nitric oxide reverses this resistance by in...
- Human Colonic Myofibroblasts Promote Expansion of CD4(+) CD25(high) Foxp3(+) Regulatory T Cells
[作者：Pinchuk, IV; Beswick, EJ; Saada, JI; Boya, G; Schmitt, D; Raju, GS; Brenmoehl, J; Rogler, G; Reyes, VE; Powell, DW,期刊：Gastroenterology, 页码：2019-2030 , 文章类型： Article，,卷期：2011年140-7]
- BACKGROUND & AIMS: Regulatory T (T-reg) cells (CD4(+) CD25(high) FoxP3(+)) regulate mucosal tolerance; their adoptive transfer prevents or reduces symptoms of colitis in mouse models of inflammatory bowel disease. Coloni...
- Interleukin-12 Converts Foxp3(+) Regulatory T Cells to Interferon-gamma-Producing Foxp3(+) T Cells That Inhibit Colitis
[作者：Feng, T; Cao, AT; Weaver, CT; Elson, CO; Cong, YZ,期刊：Gastroenterology, 页码：2031-2043 , 文章类型： Article，,卷期：2011年140-7]
- BACKGROUND & AIMS: Regulatory T (Treg) cells are plastic, but the in vivo mechanisms by which they are converted into foxhead box p3 (Foxp3(+)) interferon (IFN)-gamma(+) T cells and whether these converted cells retain t...
- Hypoxia-Inducible Factor-2 alpha Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice
[作者：Taylor, M; Qu, AJ; Anderson, ER; Matsubara, T; Martin, A; Gonzalez, FJ; Shah, YM,期刊：Gastroenterology, 页码：2044-2055 , 文章类型： Article，,卷期：2011年140-7]
- BACKGROUND & AIMS: Iron deficiency and iron overload affect over a billion people worldwide. Dietary iron absorption in the small intestine is required for systemic iron homeostasis. Ferroportin (FPN) is the only charact...
- Identification of Mutations in SLC40A1 That Affect Ferroportin Function and Phenotype of Human Ferroportin Iron Overload
[作者：Mayr, R; Griffiths, WJH; Hermann, M; McFarlane, I; Halsall, DJ; Finkenstedt, A; Douds, A; Davies, SE; Janecke, AR; Vogel, W; Cox, TM; Zoller, H,期刊：Gastroenterology, 页码：2056-U288 , 文章类型： Article，,卷期：2011年140-7]
- BACKGROUND & AIMS: Patients with ferroportin iron overload due to loss-of-function mutations in SLC40A1 have macrophage iron overload, hyperferritinemia, and normal transferrin saturation. In contrast, hepatocellular iro...
- CD8(+) T-Cell Response Promotes Evolution of Hepatitis C Virus Nonstructural Proteins
[作者：Ruhl, M; Knuschke, T; Schewior, K; Glavinic, L; Neumann-Haefelin, C; Chang, DI; Klein, M; Heinemann, FM; Tenckhoff, H; Wiese, M; Horn, PA; Viazov, S; Spengler, U; Roggendorf, M; Scherbaum, N; Nattermann, J; Hoffmann, D; Timm, J,期刊：Gastroenterology, 页码：2064-2073 , 文章类型： Article，,卷期：2011年140-7]
- BACKGROUND & AIMS: Hepatitis C virus (HCV) acquires mutations that allow it to escape the CD8(+) T-cell response, although the extent to which this process contributes to viral evolution at the population level is not cl...
- Hepatitis B Virus Limits Response of Human Hepatocytes to Interferon-alpha in Chimeric Mice
[作者：Lutgehetmann, M; Bornscheuer, T; Volz, T; Allweiss, L; Bockmann, JH; Pollok, JM; Lohse, AW; Petersen, J; Dandri, M,期刊：Gastroenterology, 页码：2074-U310 , 文章类型： Article，,卷期：2011年140-7]
- BACKGROUND & AIMS: Interferon (IFN)-alpha therapy is not effective for most patients with chronic hepatitis B virus (HBV) infection for reasons that are not clear. We investigated whether HBV infection reduced IFN-alpha-...
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