- Pharmacokinetic Modeling and [I-123]5-IA-85380 Single Photon Emission Computed Tomography Imaging in Baboons: Optimization of Dosing Regimen for ABT-089
[作者:Chin, CL; Carr, RA; Llano, DA; Barret, O; Xu, HY; Batis, J; Koren, AO; Seibyl, JP; Marsh, KC; Tamagnan, G; Decker, MW; Day, M; Fox, GB,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:716-723 , 文章类型: Article,,卷期:2011年336-3]
- Neuronal acetylcholine nicotinic receptors (nAChRs) are targets for the development of novel treatments of brain diseases. However, adverse effects (for example, emesis or nausea) associated with high drug maximal exposu...
- Phenyl Ring-Substituted Lobelane Analogs: Inhibition of [H-3]Dopamine Uptake at the Vesicular Monoamine Transporter-2
[作者:Nickell, JR; Zheng, GR; Deaciuc, AG; Crooks, PA; Dwoskin, LP,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:724-733 , 文章类型: Article,,卷期:2011年336-3]
- Lobeline attenuates the behavioral effects of methamphetamine via inhibition of the vesicular monoamine transporter (VMAT2). To increase selectivity for VMAT2, chemically defunctionalized lobeline analogs, including lobe...
- Inhibition of NADPH Oxidases Prevents Chronic Ethanol-Induced Bone Loss in Female Rats
[作者:Chen, JR; Lazarenko, OP; Shankar, K; Blackburn, ML; Lumpkin, CK; Badger, TM; Ronis, MJJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:734-742 , 文章类型: Article,,卷期:2011年336-3]
- Previous in vitro data suggest that ethanol (EtOH) activates NADPH oxidase (Nox) in osteoblasts leading to accumulation of reactive oxygen species (ROS). This might be a mechanism underlying inhibition of bone formation ...
- Amelioration of Neuropathic Pain by Novel Transient Receptor Potential Vanilloid 1 Antagonist AS1928370 in Rats without Hyperthermic Effect
[作者:Watabiki, T; Kiso, T; Kuramochi, T; Yonezawa, K; Tsuji, N; Kohara, A; Kakimoto, S; Aoki, T; Matsuoka, N,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:743-750 , 文章类型: Article,,卷期:2011年336-3]
- Transient receptor potential vanilloid 1 (TRPV1) is activated by a variety of stimulations, such as endogenous ligands and low pH, and is believed to play a role in pain transmission. TRPV1 antagonists have been reported...
- The Prototypical Ranitidine Analog JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models
[作者:Terry, AV; Buccafusco, JJ; Herman, EJ; Callahan, PM; Beck, WD; Warner, S; Vandenhuerk, L; Bouchard, K; Schwarz, GM; Gao, J; Chapman, JM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:751-766 , 文章类型: Article,,卷期:2011年336-3]
- This study was designed to evaluate further a prototypical ranitidine analog, JWS-USC-75-IX, [(3-[[[2-[[(5-dimethylaminomethyl)-2-furanyl]methyl]thio]ethyl]amino]-4-nitropyridazine, JWS], for neuropharmacologic propertie...
- In Vivo Characterization of MMP-2200, a Mixed delta/mu Opioid Agonist, in Mice
[作者:Lowery, JJ; Raymond, TJ; Giuvelis, D; Bidlack, JM; Polt, R; Bilsky, EJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:767-778 , 文章类型: Article,,卷期:2011年336-3]
- We have previously reported the chemistry and antinociceptive properties of a series of glycosylated enkephalin analogs (glycopeptides) exhibiting approximately equal affinity and efficacy at delta opioid receptors (DORs...
- Antiepileptic and Antiepileptogenic Performance of Carisbamate after Head Injury in the Rat: Blind and Randomized Studies
[作者:Eastman, CL; Verley, DR; Fender, JS; Stewart, TH; Nov, E; Curia, G; D'Ambrosio, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:779-790 , 文章类型: Article,,卷期:2011年336-3]
- Carisbamate (CRS) exhibits broad acute anticonvulsant activity in conventional anticonvulsant screens, genetic models of absence epilepsy and audiogenic seizures, and chronic spontaneous motor seizures arising after chem...
- Acotiamide Hydrochloride (Z-338), a New Selective Acetylcholinesterase Inhibitor, Enhances Gastric Motility without Prolonging QT Interval in Dogs: Comparison with Cisapride, Itopride, and Mosapride
[作者:Matsunaga, Y; Tanaka, T; Yoshinaga, K; Ueki, S; Hori, Y; Eta, R; Kawabata, Y; Yoshii, K; Yoshida, K; Matsumura, T; Furuta, S; Takei, M; Tack, J; Itoh, Z,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:791-800 , 文章类型: Article,,卷期:2011年336-3]
- Acotiamide hydrochloride (acotiamide; N-[2-[bis(1-methylethyl) amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl) amino] thiazole-4-carboxamide monohydrochloride trihydrate, Z-338) has been reported to improve meal-related...
- In Vitro Antagonistic Properties of a New Angiotensin Type 1 Receptor Blocker, Azilsartan, in Receptor Binding and Function Studies
[作者:Ojima, M; Igata, H; Tanaka, M; Sakamoto, H; Kuroita, T; Kohara, Y; Kubo, K; Fuse, H; Imura, Y; Kusumoto, K; Nagaya, H,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:801-808 , 文章类型: Article,,卷期:2011年336-3]
- The angiotensin II (AII) antagonistic action of azilsartan (AZL) [2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid] was investigated in radioligand binding ...
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