- Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2 '-deoxyuridines and their antiviral evaluation
[作者:Montagu, A; Roy, V; Balzarini, J; Snoeck, R; Andrei, G; Agrofoglio, LA,期刊:European Journal of Medicinal Chemistry, 页码:778-786 , 文章类型: Article,,卷期:2011年46-2]
- The synthesis and antiviral evaluation of a series of C5-(1,4- and 1,5-disubstituted-1,2,3-triazolo)-nucleoside derivatives is described. The key steps of this synthesis are regioselective Huisgen's 1,3-dipolar cycloaddi...
- Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors
[作者:Pinto, A; Conti, P; Grazioso, G; Tamborini, L; Madsen, U; Nielsen, B; De Micheli, C,期刊:European Journal of Medicinal Chemistry, 页码:787-793 , 文章类型: Article,,卷期:2011年46-2]
- The synthesis of four new isoxazoline-based amino acids being analogues of previously described glutamate receptor ligands is reported and their affinity for ionotropic glutamate receptors is analyzed in comparison with ...
- Synthesis and biological activity of 7H-benzo[4,5]indolo[2,3-b]-quinoxaline derivatives
[作者:Shibinskaya, MO; Karpenko, AS; Lyakhov, SA; Andronati, SA; Zholobak, NM; Spivak, NY; Samochina, NA; Shafran, LM; Zubritskye, MJ; Galat, VF,期刊:European Journal of Medicinal Chemistry, 页码:794-798 , 文章类型: Article,,卷期:2011年46-2]
- New 7-(2-aminoethyl)-7H-benzo[4,5]indolo[2,3-b]quinoxalines (13-20) were synthesized with high yields starting from 3H-benzo[e]indole-1,2-dione. These compounds were screened for the cytotoxicity, anti-viral activity, in...
- Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic
[作者:Balboni, G; Salvadori, S; Marczak, ED; Knapp, BI; Bidlack, JM; Lazarus, LH; Peng, XM; Si, YG; Neumeyer, JL,期刊:European Journal of Medicinal Chemistry, 页码:799-803 , 文章类型: Article,,卷期:2011年46-2]
- Bifunctional ligands containing an ester linkage between morphine and the delta-selective pharmacophore Dmt-Tic were synthesized, and their binding affinity and functional bioactivity at the mu, delta and kappa opioid re...
- Synthesis and anticoagulant activity of a new series of 1,4-dihydropyridine derivatives
[作者:Kumar, RS; Idhayadhulla, A; Nasser, AJA; Selvin, J,期刊:European Journal of Medicinal Chemistry, 页码:804-810 , 文章类型: Article,,卷期:2011年46-2]
- A series of 1,4-dihydropyridine derivatives (1a-g) were prepared from three compounds condensation reaction of ethylacetoacetate, aromatic aldehyde and ammonium hydroxide. A new series of compounds (2a-g) were prepared f...
- Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage - Implications for early Myasthenia gravis treatment
[作者:Musilek, K; Komloova, M; Holas, O; Hrabinova, M; Pohanka, M; Dohnal, V; Nachon, F; Dolezal, M; Kuca, K,期刊:European Journal of Medicinal Chemistry, 页码:811-818 , 文章类型: Article,,卷期:2011年46-2]
- Inhibitors of acetylcholinesterase are compounds widely used in the treatment of various diseases, such as Alzheimer's disease, glaucoma and Myasthenia gravis (MG). Compounds used in the therapy of MG posses a positive c...
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