- Synthesis and optimization of antitubercular activities in a series of 4-(aryloxy) phenyl cyclopropyl methanols
[作者:Bisht, SS; Dwivedi, N; Chaturvedi, V; Anand, N; Misra, M; Sharma, R; Kumar, B; Dwivedi, R; Singh, S; Sinha, SK; Gupta, V; Mishra, PR; Dwivedi, AK; Tripathi, RP,期刊:European Journal of Medicinal Chemistry, 页码:5965-5978 , 文章类型: Article,,卷期:2010年45-12]
- A series of [4-(aryloxy)phenyl]cyclopropyl methanones were synthesized by reaction of different benzyl alcohols with 4-chloro-4'-fluorobutyrophenone in DMF in the presence of NaH/TBAB. The methanones were further reduced...
- Isochaihulactone analogues: Synthesis and anti-proliferative activity of novel dibenzylbutyrolactones
[作者:Alizadeh, BH; Foroumadi, A; Emami, S; Khoobi, M; Panah, F; Ardestani, SK; Shafiee, A,期刊:European Journal of Medicinal Chemistry, 页码:5979-5984 , 文章类型: Article,,卷期:2010年45-12]
- A series of dibenzyl-gamma-butyrolactones bearing a hydroxyl group at the benzylic position of 3-benzyl group were synthesized as hydrated analogue of isochaihulactone and evaluated against breast cancer human cell lines...
- 4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: Synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation
[作者:Yadav, S; Kumar, P; De Clercq, E; Balzarini, J; Pannecouque, C; Dewan, SK; Narasimhan, B,期刊:European Journal of Medicinal Chemistry, 页码:5985-5997 , 文章类型: Article,,卷期:2010年45-12]
- A series of 4-[1-(substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzene sulphonic acids (1-20) was synthesized and evaluated, in vitro, for their antimicrobial activity and the results indicated that compounds 4-[...
- Novel conformationally restricted triazole derivatives with potent antifungal activity
[作者:Wang, WY; Wang, SZ; Liu, Y; Dong, GQ; Cao, YB; Miao, ZY; Yao, JZ; Zhang, WN; Sheng, CQ,期刊:European Journal of Medicinal Chemistry, 页码:6020-6026 , 文章类型: Article,,卷期:2010年45-12]
- In continuation of our work on azole antifungal agents, a series of new conformationally restricted triazole derivatives possessing benzylpiperidin-4-yl methyl amino side chains were designed and synthesized. All the new...
- Synthesis, NMR characterization and in vitro cytotoxicity evaluation of new poly (oxyethylene aminophosphonate)s
[作者:Kraicheva, I; Bogomilova, A; Tsacheva, I; Momekov, G; Momekova, D; Troev, K,期刊:European Journal of Medicinal Chemistry, 页码:6039-6044 , 文章类型: Article,,卷期:2010年45-12]
- The synthesis of four novel poly(oxyethylene aminophosphonate)s through an addition of poly(oxyethylene H-phosphonate)s to N-(4-dimethylaminobenzylidene)-p-toluidine or N-furfurylidene-p-toluidine is reported. The IR and...
- Synthesis of novel alpha-santonin derivatives as potential cytotoxic agents
[作者:Arantes, FFP; Barbosa, LCA; Maltha, CRA; Demuner, AJ; da Costa, PM; Ferreira, JRO; Costa-Lotufo, LV; Moraes, MO; Pessoa, C,期刊:European Journal of Medicinal Chemistry, 页码:6045-6051 , 文章类型: Article,,卷期:2010年45-12]
- Ten novel alpha-santonin derivatives have been synthesized as cytotoxic agents. The in vitro antitumor activity of these compounds has been evaluated against cancer cells lines. Structure-activity relationships indicate ...
- Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells
[作者:Lee, K; Lee, JH; Boovanahalli, SK; Choi, Y; Choo, SJ; Yoo, ID; Kim, DH; Yun, MY; Lee, GW; Song, GY,期刊:European Journal of Medicinal Chemistry, 页码:5567-5575 , 文章类型: Article,,卷期:2010年45-12]
- We report the synthesis of a novel series of highly potent melanin inhibitors which were obtained through structural modification of an anticancer compound S-(+)-decursinol. The in vitro inhibitory potencies of the newly...
- New class of potent antitumor acylhydrazone derivatives containing furan
[作者:Cui, ZN; Li, Y; Ling, Y; Huang, JA; Cui, JR; Wang, RQ; Yang, XL,期刊:European Journal of Medicinal Chemistry, 页码:5576-5584 , 文章类型: Article,,卷期:2010年45-12]
- A pair of chemical isomeric structures of N-acylhydrazone compounds I and II were designed and synthesized. The reaction was carried out with high diastereoselectivity to obtain one configurational isomer in excellent yi...
- Investigating the structural basis of arylamides to improve potency against M. tuberculosis strain through molecular dynamics simulations
[作者:Punkvang, A; Saparpakorn, P; Hannongbua, S; Wolschann, P; Beyer, A; Pungpo, P,期刊:European Journal of Medicinal Chemistry, 页码:5585-5593 , 文章类型: Article,,卷期:2010年45-12]
- Arylamides have been identified as direct InhA inhibitors which overcome the drug-resistance problem of isoniazid, the first-line drug for tuberculosis treatment. However, arylamide properties are not yet optimal against...
- Biological evaluation of donor-acceptor aminonaphthoquinones as antitumor agents
[作者:Benites, J; Valderrama, JA; Bettega, K; Pedrosa, RC; Calderon, PB; Verrax, J,期刊:European Journal of Medicinal Chemistry, 页码:6052-6057 , 文章类型: Article,,卷期:2010年45-12]
- Several members of the phenylamino-1,4-naphthoquinone series were prepared in order to investigate structure-activity relationships (SAR) and to explore the antitumor effects associated with this scaffold. The cytotoxic ...
- Synthesis and antitumor activity of some 2, 3-disubstituted quinazolin-4(3H)-ones and 4, 6-disubstituted-1, 2, 3, 4-tetrahydroquinazolin-2H-ones
[作者:Gawad, NMA; Georgey, HH; Youssef, RM; El-Sayed, NA,期刊:European Journal of Medicinal Chemistry, 页码:6058-6067 , 文章类型: Article,,卷期:2010年45-12]
- The synthesis of some new 3-substituted quinazolin-4(3H)-ones and 3,4-dihydro-quinazolin-2(1H)-one derivatives and their biological evaluation as antitumor agents using the National Cancer Institute (NCI), disease orient...
|