- Regulation of hematopoietic stem cells by their mature progeny
[作者:de Graaf, CA; Kauppi, M; Baldwin, T; Hyland, CD; Metcalf, D; Willson, TA; Carpinelli, MR; Smyth, GK; Alexander, WS; Hilton, DJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21689-21694 , 文章类型: Article,,卷期:2010年107-50]
- Thrombopoietin (TPO), acting through its receptor Mpl, has two major physiological roles: ensuring production of sufficient platelets via stimulation of megakaryocyte production and maintaining hematopoietic stem cell (H...
- Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis
[作者:Trichonas, G; Murakami, Y; Thanos, A; Morizane, Y; Kayama, M; Debouck, CM; Hisatomi, T; Miller, JW; Vavvas, DG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21695-21700 , 文章类型: Article,,卷期:2010年107-50]
Apoptosis has been shown to be a significant form of cell loss in many diseases. Detachment of photoreceptors from the retinal pigment epithelium, as seen in various retinal disorders, causes photoreceptor loss and su...
- Topological change disturbs object continuity in attentive tracking
[作者:Zhou, K; Luo, HA; Zhou, TG; Zhuo, Y; Chen, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21920-21924 , 文章类型: Article,,卷期:2010年107-50]
- The question of what is a perceptual object is one of the most central and also controversial issues in cognitive science. According to the topological approach to perceptual organization, the core intuitive notion of an...
- Global capacity for emerging infectious disease detection
[作者:Chan, EH; Brewer, TF; Madoff, LC; Pollack, MP; Sonricker, AL; Keller, M; Freifeld, CC; Blench, M; Mawudeku, A; Brownstein, JS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21701-21706 , 文章类型: Article,,卷期:2010年107-50]
- The increasing number of emerging infectious disease events that have spread internationally, such as severe acute respiratory syndrome (SARS) and the 2009 pandemic A/H1N1, highlight the need for improvements in global o...
- Cost-effectiveness of dryland forest restoration evaluated by spatial analysis of ecosystem services
[作者:Birch, JC; Newton, AC; Aquino, CA; Cantarello, E; Echeverria, C; Kitzberger, T; Schiappacasse, I; Garavito, NT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21925-21930 , 文章类型: Article,,卷期:2010年107-50]
- Although ecological restoration is widely used to combat environmental degradation, very few studies have evaluated the cost-effectiveness of this approach. We examine the potential impact of forest restoration on the va...
- Histone H3K27ac separates active from poised enhancers and predicts developmental state
[作者:Creyghton, MP; Cheng, AW; Welstead, GG; Kooistra, T; Carey, BW; Steine, EJ; Hanna, J; Lodato, MA; Frampton, GM; Sharp, PA; Boyer, LA; Young, RA; Jaenisch, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21931-21936 , 文章类型: Article,,卷期:2010年107-50]
- Developmental programs are controlled by transcription factors and chromatin regulators, which maintain specific gene expression programs through epigenetic modification of the genome. These regulatory events at enhancer...
- DNA damage regulates the mobility of Brca2 within the nucleoplasm of living cells
[作者:Jeyasekharana, AD; Ayoub, N; Mahen, R; Ries, J; Esposito, A; Rajendra, E; Hattori, H; Kulkarni, RP; Venkitaraman, AR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21937-21942 , 文章类型: Article,,卷期:2010年107-50]
- How the biochemical reactions that lead to the repair of DNA damage are controlled by the diffusion and availability of protein reactants within the nucleoplasm is poorly understood. Here, we use gene targeting to replac...
- Reclaiming freshwater sustainability in the Cadillac Desert
[作者:Sabo, JL; Sinha, T; Bowling, LC; Schoups, GHW; Wallender, WW; Campana, ME; Cherkauer, KA; Fuller, PL; Graf, WL; Hopmans, JW; Kominoski, JS; Taylor, C; Trimble, SW; Webb, RH; Wohl, EE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21263-21270 , 文章类型: Article,,卷期:2010年107-50]
- Increasing human appropriation of freshwater resources presents a tangible limit to the sustainability of cities, agriculture, and ecosystems in the western United States. Marc Reisner tackles this theme in his 1986 clas...
- Future dryness in the southwest US and the hydrology of the early 21st century drought
[作者:Cayan, DR; Das, T; Pierce, DW; Barnett, TP; Tyree, M; Gershunov, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21271-21276 , 文章类型: Article,,卷期:2010年107-50]
- Recently the Southwest has experienced a spate of dryness, which presents a challenge to the sustainability of current water use by human and natural systems in the region. In the Colorado River Basin, the early 21st cen...
- Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes
[作者:Yang, JB; Huang, J; Dasgupta, M; Sears, N; Miyagi, M; Wang, BL; Chance, MR; Chen, X; Du, YP; Wang, YX; An, LZ; Wang, Q; Lu, T; Zhang, XD; Wang, ZH; Stark, GR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21499-21504 , 文章类型: Article,,卷期:2010年107-50]
- Following its tyrosine phosphorylation, STAT3 is methylated on K140 by the histone methyl transferase SET9 and demethylated by LSD1 when it is bound to a subset of the promoters that it activates. Methylation of K140 is ...
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