- Chemical generation of bispecific antibodies
[作者：Doppalapudi, VR; Huang, J; Liu, DG; Jin, P; Liu, B; Li, LN; Desharnais, J; Hagen, C; Levin, NJ; Shields, MJ; Parish, M; Murphy, RE; Del Rosario, J; Oates, BD; Lai, JY; Matin, MJ; Ainekulu, Z; Bhat, A; Bradshaw, CW; Woodnutt, G; Lerner, RA; Lappe, RW,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：22611-22616 , 文章类型： Article，,卷期：2010年107-52]
- Bispecific antibodies (BsAbs) are regarded as promising therapeutic agents due to their ability to simultaneously bind two different antigens. Several bispecific modalities have been developed, but their utility is limit...
- IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity
[作者：Ricardo-Gonzalez, RR; Eagle, AR; Odegaard, JI; Jouihan, H; Morel, CR; Heredia, JE; Mukundan, L; Wu, D; Locksley, RM; Chawla, A,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：22617-22622 , 文章类型： Article，,卷期：2010年107-52]
- Immune cells take residence in metabolic tissues, providing a framework for direct regulation of nutrient metabolism. Despite conservation of this anatomic relationship through evolution, the signals and mechanisms by wh...
- Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C
[作者：Ming, M; Shea, CR; Guo, XM; Li, XL; Soltani, K; Han, WN; He, YY,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：22623-22628 , 文章类型： Article，,卷期：2010年107-52]
- Disruption of the nucleotide excision repair (NER) pathway by mutations can cause xeroderma pigmentosum, a syndrome predisposing affected individuals to development of skin cancer. The xeroderma pigmentosum C (XPC) prote...
- microRNA miR-275 is indispensable for blood digestion and egg development in the mosquito Aedes aegypti
[作者：Bryant, B; Macdonald, W; Raikhel, AS,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：22391-22398 , 文章类型： Article，,卷期：2010年107-52]
- The mosquito Aedes aegypti is the major vector of arboviral diseases, particularly of Dengue fever, of which there are more than 100 million cases annually. Mosquitoes, such as A. aegypti, serve as vectors for disease pa...
- Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex
[作者：Rathore, SS; Bend, EG; Yu, HJ; Hammarlund, M; Jorgensen, EM; Shen, JS,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：22399-22406 , 文章类型： Article，,卷期：2010年107-52]
- Intracellular membrane fusion is mediated by the concerted action of N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and Sec1/Munc18 (SM) proteins. During fusion, SM proteins bind the N-terminal p...
- Whispering-gallery mode resonators for highly unidirectional laser action
[作者：Wang, QJ; Yan, CL; Yu, NF; Unterhinninghofen, J; Wiersig, J; Pflugl, C; Diehl, L; Edamura, T; Yamanishi, M; Kan, H; Capasso, F,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：22407-22412 , 文章类型： Article，,卷期：2010年107-52]
- Optical microcavities can be designed to take advantage of total internal reflection, which results in resonators supporting whispering-gallery modes (WGMs) with a high-quality factor (Q factor). One of the crucial probl...
- Dynamic self-assembly and control of microfluidic particle crystals
[作者：Lee, W; Amini, H; Stone, HA; Di Carlo, D,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：22413-22418 , 文章类型： Article，,卷期：2010年107-52]
- Engineered two-phase microfluidic systems have recently shown promise for computation, encryption, and biological processing. For many of these systems, complex control of dispersed-phase frequency and switching is enabl...
- Definition of the intermediates and mechanism of the anticancer drug bleomycin using nuclear resonance vibrational spectroscopy and related methods
[作者：Liu, LV; Bell, CB; Wong, SD; Wilson, SA; Kwak, Y; Chow, MS; Zhao, JY; Hodgson, KO; Hedman, B; Solomon, EI,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：22419-22424 , 文章类型： Article，,卷期：2010年107-52]
- Bleomycin (BLM) is a glycopeptide anticancer drug capable of effecting single- and double-strand DNA cleavage. The last detectable intermediate prior to DNA cleavage is a low spin Fe-III peroxy level species, termed acti...
- Morphologically controlled synthesis of colloidal upconversion nanophosphors and their shape-directed self-assembly
[作者：Ye, XC; Collins, JE; Kang, YJ; Chen, J; Chen, DTN; Yodh, AG; Murray, CB,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：22430-22435 , 文章类型： Article，,卷期：2010年107-52]
- We report a one-pot chemical approach for the synthesis of highly monodisperse colloidal nanophosphors displaying bright upconversion luminescence under 980 nm excitation. This general method optimizes the synthesis with...
- Inferring social ties from geographic coincidences
[作者：Crandall, DJ; Backstrom, L; Cosley, D; Suri, S; Huttenlocher, D; Kleinberg, J,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：22436-22441 , 文章类型： Article，,卷期：2010年107-52]
- We investigate the extent to which social ties between people can be inferred from co-occurrence in time and space: Given that two people have been in approximately the same geographic locale at approximately the same ti...
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