- Zinc Monotherapy Is Not as Effective as Chelating Agents in Treatment of Wilson Disease
[作者：Weiss, KH; Gotthardt, DN; Klemm, D; Merle, U; Ferenci-Foerster, D; Schaefer, M; Ferenci, P; Stremmel, W,期刊：Gastroenterology, 页码：1189-+ , 文章类型： Article，,卷期：2011年140-4]
- BACKGROUND & AIMS: Wilson disease is a genetic disorder that affects copper storage, leading to liver failure and neurologic deterioration. Patients are treated with copper chelators and zinc salts, but it is not clear w...
- Sex and Acquired Cofactors Determine Phenotypes of Ferroportin Disease
[作者：Le Lan, C; Mosser, A; Ropert, M; Detivaud, L; Loustaud-Ratti, V; Vital-Durand, D; Roget, L; Bardou-Jacquet, E; Turlin, B; David, V; Loreal, O; Deugnier, Y; Brissot, P; Jouanolle, AM,期刊：Gastroenterology, 页码：1199-+ , 文章类型： Article，,卷期：2011年140-4]
- BACKGROUND & AIMS: Ferroportin disease is characterized by iron overload. It has an autosomal-dominant pattern of inheritance and has been associated with mutations in the SLC40A1 gene, which encodes the cellular iron ex...
- The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding
[作者：Marchiando, AM; Shen, L; Graham, WV; Edelblum, KL; Duckworth, CA; Guan, YF; Montrose, MH; Turner, JR; Watson, AJM,期刊：Gastroenterology, 页码：1208-+ , 文章类型： Article，,卷期：2011年140-4]
- BACKGROUND & AIMS: Tumor necrosis factor (TNF) increases intestinal epithelial cell shedding and apoptosis, potentially challenging the barrier between the gastrointestinal lumen and internal tissues. We investigated the...
- GATA Factors Regulate Proliferation, Differentiation, and Gene Expression in Small Intestine of Mature Mice
[作者：Beuling, E; Baffour-Awuah, NYA; Stapleton, KA; Aronson, BE; Noah, TK; Shroyer, NF; Duncan, SA; Fleet, JC; Krasinski, SD,期刊：Gastroenterology, 页码：1219-+ , 文章类型： Article，,卷期：2011年140-4]
- BACKGROUND & AIMS: GATA transcription factors regulate proliferation, differentiation, and gene expression in multiple organs. GATA4 is expressed in the proximal 85% of the small intestine and regulates the jejunal-ileal...
- Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells
[作者：Pellegrinet, L; Rodilla, V; Liu, ZY; Chen, SA; Koch, U; Espinosa, L; Kaestner, KH; Kopan, R; Lewis, J; Radtke, F,期刊：Gastroenterology, 页码：1230-+ , 文章类型： Article，,卷期：2011年140-4]
- BACKGROUND & AIMS: Ablation of Notch signaling within the intestinal epithelium results in loss of proliferating crypt progenitors due to their conversion into postmitotic secretory cells. We aimed to confirm that Notch ...
- Use of Methylation Patterns to Determine Expansion of Stem Cell Clones in Human Colon Tissue
[作者：Graham, TA; Humphries, A; Sanders, T; Rodriguez-Justo, M; Tadrous, PJ; Preston, SL; Novelli, MR; Leedham, SJ; McDonald, SAC; Wright, NA,期刊：Gastroenterology, 页码：1241-+ , 文章类型： Article，,卷期：2011年140-4]
- BACKGROUND & AIMS: It is a challenge to determine the dynamics of stem cells within human epithelial tissues such as colonic crypts. By tracking methylation patterns of nonexpressed genes, we have been able to determine ...
- The Clonal Origins of Dysplasia From Intestinal Metaplasia in the Human Stomach
[作者：Gutierrez-Gonzalez, L; Graham, TA; Rodriguez-Justo, M; Leedham, SJ; Novelli, MR; Gay, LJ; Ventayol-Garcia, T; Green, A; Mitchell, I; Stoker, DL; Preston, SL; Bamba, S; Yamada, E; Kishi, Y; Harrison, R; Jankowski, JA; Wright, NA; McDonald, SAC,期刊：Gastroenterology, 页码：1251-+ , 文章类型： Article，,卷期：2011年140-4]
- BACKGROUND & AIMS: Studies of the clonal architecture of gastric glands with intestinal metaplasia are important in our understanding of the progression from metaplasia to dysplasia. It is not clear if dysplasias are der...
- Intestinal DMT1 Cotransporter Is Down-regulated by Hepcidin via Proteasome Internalization and Degradation
[作者：Brasse-Lagnel, C; Karim, Z; Letteron, P; Bekri, S; Bado, A; Beaumont, C,期刊：Gastroenterology, 页码：1261-+ , 文章类型： Article，,卷期：2011年140-4]
- BACKGROUNDS & AIMS: The mechanism by which hepcidin regulates iron export from macrophages has been well established and is believed to involve degradation of ferroportin. However, in the small intestine, hepcidin's mech...
- Modifying the Protease, Antiprotease Pattern by Elafin Overexpression Protects Mice From Colitis
[作者：Motta, JP; Magne, L; Descamps, D; Rolland, C; Squarzoni-Dale, C; Rousset, P; Martin, L; Cenac, N; Balloy, V; Huerre, M; Frohlich, LF; Jenne, D; Wartelle, J; Belaaouaj, A; Mas, E; Vinel, JP; Alric, L; Chignard, M; Vergnolle, N; Sallenave, JM,期刊：Gastroenterology, 页码：1272-1282 , 文章类型： Article，,卷期：2011年140-4]
- BACKGROUND & AIMS: Colonic tissues of patients with inflammatory bowel disease have been reported to have increased proteolytic activity, but no studies have clearly addressed the role of the balance between proteases an...
- Synergistic Role of TRPV1 and TRPA1 in Pancreatic Pain and Inflammation
[作者：Schwartz, ES; Christianson, JA; Chen, XW; La, JH; Davis, BM; Albers, KM; Gebhart, GF,期刊：Gastroenterology, 页码：1283-+ , 文章类型： Article，,卷期：2011年140-4]
- BACKGROUND & AIMS: The transient receptor potential (TRP) channels TRPV1 and TRPA1 have each been associated with regulation of efferent properties of primary afferent neurons that initiate neurogenic inflammation and ar...
- Atrial Natriuretic Factor Stimulates Efflux of cAMP in Rat Exocrine Pancreas via Multidrug Resistance-Associated Proteins
[作者：Rodriguez, MR; Diez, F; Ventimiglia, MS; Morales, V; Copsel, S; Vatta, MS; Davio, CA; Bianciotti, LG,期刊：Gastroenterology, 页码：1292-1302 , 文章类型： Article，,卷期：2011年140-4]
- BACKGROUND & AIMS: Atrial natriuretic factor (ANF) prevents increases in intracellular levels of cAMP that are induced by secretin in the exocrine pancreas. We investigated the contribution of cyclic adenosine monophosph...
- Inactivation of Brca2 Promotes Trp53-Associated but Inhibits KrasG12D-Dependent Pancreatic Cancer Development in Mice
[作者：Rowley, M; Ohashi, A; Mondal, G; Mills, L; Yang, L; Zhang, LZ; Sundsbak, R; Shapiro, V; Muders, MH; Smyrk, T; Couch, FJ,期刊：Gastroenterology, 页码：1303-+ , 文章类型： Article，,卷期：2011年140-4]
- BACKGROUND & AIMS: Inherited mutations in the BRCA2 tumor suppressor have been associated with an increased risk of pancreatic cancer. To establish the contribution of Brca2 to pancreatic cancer we developed a mouse mode...
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