- Gambogic acid inhibits Hsp90 and deregulates TNF-alpha/NF-kappa B in HeLa cells
[作者:Zhang, LR; Yi, YT; Chen, JJ; Sun, YF; Guo, QJ; Zheng, ZH; Song, SY,期刊:Biochemical and Biophysical Research Communications, 页码:282-287 , 文章类型: Article,,卷期:2010年403-3-4]
- Gambogic acid (GB) is an important anti-cancer drug candidate, but the target protein by which it exerts its anti-cancer effects has not been identified. This study is the first to show that GB inhibits heat shock protei...
- Chlorambucil-sensitive and -resistant lymphoid cells display different responses to the histone deacetylase inhibitor, sodium butyrate
[作者:Kwa, FAA; Cole-Sinclair, M; Kapuscinski, M,期刊:Biochemical and Biophysical Research Communications, 页码:288-292 , 文章类型: Article,,卷期:2010年403-3-4]
- Clinical chemoresistance is a frequent complication of alkylating agent treatment of malignant tumours. Chromatin remodelling using histone deacetylase inhibitors (e.g., sodium butyrate, NaBu) may increase target cell ch...
- A role for MGA2, but not SPT23, in activation of transcription of ERG1 in Saccharomyces cerevisiae
[作者:Rice, C; Cooke, M; Treloar, N; Vollbrecht, P; Stukey, J; McDonough, V,期刊:Biochemical and Biophysical Research Communications, 页码:293-297 , 文章类型: Article,,卷期:2010年403-3-4]
- The Saccharomyces cerevisiae MGA2 gene encodes an important regulator of unsaturated fatty acid production, by controlling transcription and mRNA stability of OLE1, the gene encoding the Delta 9 fatty acid desaturase. Li...
- Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipotent hepatic progenitor cells
[作者:Sakai, H; Tagawa, Y; Tamai, M; Motoyama, H; Ogawa, S; Soeda, J; Nakata, T; Miyagawa, S,期刊:Biochemical and Biophysical Research Communications, 页码:298-304 , 文章类型: Article,,卷期:2010年403-3-4]
- Hepatic stem/progenitor cells are one of several cell sources that show promise for restoration of liver mass and function. Although hepatic progenitor cells (HPCs), including oval cells, are induced by administration of...
- Expression of semaphorin 3A and its receptors during mouse corneal development
[作者:Ko, JA; Mizuno, Y; Yanai, R; Chikama, T; Sonoda, KH,期刊:Biochemical and Biophysical Research Communications, 页码:305-309 , 文章类型: Article,,卷期:2010年403-3-4]
- Semaphorin 3A (Sema3A) functions to guide the growth of neurons during development, with its effects being mediated by receptor complexes composed of neuropilin (Npn) and plexin (Plx) proteins. We have now examined the e...
- TAp63 plays compensatory roles in p53-deficient cancer cells under genotoxic stress
[作者:Yao, JY; Chen, JK,期刊:Biochemical and Biophysical Research Communications, 页码:310-315 , 文章类型: Article,,卷期:2010年403-3-4]
- p53, p63, and p73 belong to the p53 family of proteins, which mediate development, differentiation, and various other cellular responses. p53 is involved in many anti-cancer mechanisms, such as cell cycle regulation, apo...
- Niemann-Pick type C fibroblasts have a distinct microRNA profile related to lipid metabolism and certain cellular components
[作者:Ozsait, B; Komurcu-Bayrak, E; Levula, M; Erginel-Unaltuna, N; Kahonen, M; Rai, M; Lehtimaki, T; Laaksonen, R,期刊:Biochemical and Biophysical Research Communications, 页码:316-321 , 文章类型: Article,,卷期:2010年403-3-4]
- MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression at post-transcriptional level. Dysregulation of miRNA expression may lead to severe pathophysiologies in human cells. Niemann-Pick type C (NPC) disease...
- Role of resveratrol in FOXO1-mediated gluconeogenic gene expression in the liver
[作者:Park, JM; Kim, TH; Bae, JS; Kim, MY; Kim, KS; Ahn, YH,期刊:Biochemical and Biophysical Research Communications, 页码:329-334 , 文章类型: Article,,卷期:2010年403-3-4]
- During a state of fasting, the blood glucose level is maintained by hepatic gluconeogenesis. SIRT1 is an important metabolic regulator during nutrient deprivation and the liver-specific knockdown of SIRT1 resulted in dec...
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