- A Mouse Model of beta-Thalassemia Shows a Liver-Specific Down-Regulation of Abcc6 Expression
[作者：Martin, L; Douett, V; VanWartt, CM; Heller, MB; Le Saux, O,期刊：American Journal of Pathology, 页码：774-783 , 文章类型： Article，,卷期：2011年178-2]
- beta-Thalassemia and pseudoxanthoma elasticum (PXE) are distinct genetic disorders. Yet, a dystrophic mineralization phenotype similar to PXE has frequently been associated with (beta-thalassemia or sickle cell anemia pa...
- Regulation of Biliary Proliferation by Neuroendocrine Factors Implications for the Pathogenesis of Cholestatic Liver Diseases
[作者：Munshi, MK; Priester, S; Gaudio, E; Yang, FQ; Alpini, G; Mancinelli, R; Wise, C; Meng, FY; Franchitto, A; Onori, P; Glaser, SS,期刊：American Journal of Pathology, 页码：472-484 , 文章类型： Review，,卷期：2011年178-2]
- The proliferation of cholangiocytes occurs during the progression of cholestatic liver diseases and is critical for the maintenance and/or restoration of biliary mass during bile duct damage. The ability of cholangiocyte...
- Inhibition of Activin Receptor Type IIB Increases Strength and Lifespan in Myotubularin-Deficient Mice
[作者：Lawlor, MW; Read, BP; Edelstein, R; Yang, N; Pierson, CR; Stein, MJ; Wermer-Colan, A; Buj-Bello, A; Lachey, JL; Seehra, JS; Beggs, AH,期刊：American Journal of Pathology, 页码：784-793 , 文章类型： Article，,卷期：2011年178-2]
- X-linked myotubular myopathy (XLMTM) is a congenital disorder caused by deficiency of the lipid phosphatase, myotubularin. Patients with XLMTM often have severe perinatal weakness that requires mechanical ventilation to ...
- IL-21 and IL-21 Receptor Expression in Lymphocytes and Neurons in Multiple Sclerosis Brain
[作者：Tzartos, JS; Craner, MJ; Friese, MA; Jakobsen, KB; Newcombe, J; Esiri, MM; Fugger, L,期刊：American Journal of Pathology, 页码：794-802 , 文章类型： Article，,卷期：2011年178-2]
- IL-17 producing CD4(+) T cells (Th-17) contribute to the pathogenesis of experimental autoimmune encephalomyelitis and are associated with active disease in multiple sclerosis (MS). In addition to IL-17, Th-17 cells can ...
- Accelerated Human Mutant Tau Aggregation by Knocking Out Murine Tau in a Transgenic Mouse Model
[作者：Ando, K; Leroy, K; Heraud, C; Yilmaz, Z; Authelet, M; Suain, V; De Decker, R; Brion, JP,期刊：American Journal of Pathology, 页码：803-816 , 文章类型： Article，,卷期：2011年178-2]
- Many models of human tauopathies have been generated in flake by expression of a human mutant tau with maintained expression of mouse endogenous tau. Because murine tau might interfere with the toxic effects of human mut...
- Bone Marrow-Derived Progenitor Cells Do Not Contribute to Podocyte Turnover in the Puromycin Aminoglycoside and Renal Ablation Models in Rats
[作者：Meyer-Schwesinger, C; Lange, C; Brocker, V; Agustian, PA; Lehmann, U; Raabe, A; Brinkmeyer, M; Kobayashi, E; Schiffer, M; Busche, G; Kreipe, HH; Thaiss, F; Becker, JU,期刊：American Journal of Pathology, 页码：494-499 , 文章类型： Article，,卷期：2011年178-2]
- A key event in the progression of glomerular disease is podocyte loss that leads to focal and segmental glomerulosclerosis (FSGS). Because adult podocytes are postmitotic cells, podocyte replacement by bone marrow-derive...
- The Development of Cutaneous Neurofibromas
[作者：Jouhilahti, EM; Peltonen, S; Callens, T; Jokinen, E; Heape, AM; Messiaen, L; Peltonen, J,期刊：American Journal of Pathology, 页码：500-505 , 文章类型： Article，,卷期：2011年178-2]
- Cutaneous neurofibromas are the hallmarks of neurofibromatosis type 1 (NF1). They are composed of multiple cell types, and traditionally they are believed to arise from small nerve tributaries of the skin. A key finding ...
- Ophthalmic Pterygium A Stem Cell Disorder with Premalignant Features
[作者：Chui, J; Coroneo, MT; Tat, LT; Crouch, R; Wakefield, D; Di Girolamo, N,期刊：American Journal of Pathology, 页码：817-827 , 文章类型： Article，,卷期：2011年178-2]
- Pterygia are common ocular surface lesions thought to originate from limbal stem cells altered by chronic UV exposure. Traditionally regarded as a degenerative condition, pterygia also display tumor-like features, such a...
- Reduced Stathmin-1 Expression in Natural Killer Cells Associated with Spontaneous Abortion
[作者：Lin, Y; Li, C; Shan, B; Wang, WJ; Saito, S; Xu, JH; Di, JF; Zhong, YM; Li, DJ,期刊：American Journal of Pathology, 页码：506-514 , 文章类型： Article，,卷期：2011年178-2]
- Female CBA/J mice impregnated by male DBA/2J mice (CBA/J x DBA/2J matings) are prone to spontaneous abortion, although the reason for this is unclear. In this study, the stathmin-1 expression pattern was evaluated in ute...
- Expression of Hypoxic Marker CA IX Is Regulated by Site-Specific DNA Methylation and Is Associated with the Histology of Gastric Cancer
[作者：Nakamura, J; Kitajima, Y; Kai, K; Hashiguchi, K; Hiraki, M; Noshiro, H; Miyazaki, K,期刊：American Journal of Pathology, 页码：515-524 , 文章类型： Article，,卷期：2011年178-2]
- The hypoxic marker carbonic anhydrase (CA) IX has been recognized as a tumor-associated protein and is essential for cancer development. However, because CA IX expression does not always correlate with hypoxia, its regul...
- Arachidonic Acid Pathway Members PLA2G7, HPGD, EPHX2, and CYP4F8 Identified as Putative Novel Therapeutic Targets in Prostate Cancer
[作者：Vainio, P; Gupta, S; Ketola, K; Mirtti, T; Mpindi, JP; Kohonen, P; Fey, V; Perala, M; Smit, F; Verhaegh, G; Schalken, J; Alanen, KA; Kallioniemi, O; Iljin, K,期刊：American Journal of Pathology, 页码：525-536 , 文章类型： Article，,卷期：2011年178-2]
- The arachidonic acid and prostaglandin pathway has been implicated in prostate carcinogenesis, but comprehensive studies of the individual members in this key pathway are lacking. Here, we first conducted a systematic bi...
- Isolation and Characterization of Progenitor-Like Cells from Human Renal Proximal Tubules
[作者：Lindgren, D; Bostrom, AK; Nilsson, K; Hansson, J; Sjolund, J; Moller, C; Jirstrom, K; Nilsson, E; Landberg, G; Axelson, H; Johansson, ME,期刊：American Journal of Pathology, 页码：828-837 , 文章类型： Article，,卷期：2011年178-2]
- The tubules of the kidney display a remarkable capacity for self-renewal on damage. Whether this regeneration is mediated by dedifferentiating surviving cells or, as recently suggested, by stern cells has not been unequi...
- Increased Expression of P-Glycoprotein Is Associated with Doxorubicin Chemoresistance in the Metastatic 4T1 Breast Cancer Model
[作者：Bao, LL; Haque, A; Jackson, K; Hazari, S; Moroz, K; Jetly, R; Dash, S,期刊：American Journal of Pathology, 页码：838-852 , 文章类型： Article，,卷期：2011年178-2]
- Development of drug resistance is one of the major causes of breast cancer treatment failure. The goal of this study was to understand the chemoresistance mechanism using the highly metastatic 4T1 breast cancer model, wh...
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