- Tonoplast-localized Abc2 Transporter Mediates Phytochelatin Accumulation in Vacuoles and Confers Cadmium Tolerance
[作者:Mendoza-Cozatl, DG; Zhai, ZY; Jobe, TO; Akmakjian, GZ; Song, WY; Limbo, O; Russell, MR; Kozlovskyy, VI; Martinoia, E; Vatamaniuk, OK; Russell, P; Schroeder, JI,期刊:Journal of Biological Chemistry, 页码:889-898 , 文章类型: Article,,卷期:2010年285-52]
- Phytochelatins mediate tolerance to heavy metals in plants and some fungi by sequestering phytochelatin-metal complexes into vacuoles. To date, only Schizosaccharomyces pombe Hmt1 has been described as a phytochelatin tr...
- Arginine 104 Is a Key Catalytic Residue in Leukotriene C-4 Synthase
[作者:Rinaldo-Matthis, A; Wetterholm, A; Molina, DM; Holm, J; Niegowski, D; Ohlson, E; Nordlund, P; Morgenstern, R; Haeggstrom, JZ,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- Human leukotriene C-4 synthase (hLTC(4)S) is an integral membrane enzyme that conjugates leukotriene (LT) A(4) with glutathione to form LTC4, a precursor to the cysteinyl leukotrienes (LTC4, LTD4, and LTE4) that are invo...
- Phosphorylation of Aquaporin-2 Regulates Its Water Permeability
[作者:Eto, K; Noda, Y; Horikawa, S; Uchida, S; Sasaki, S,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- Vasopressin-regulated water reabsorption through the water channel aquaporin-2 (AQP2) in renal collecting ducts maintains body water homeostasis. Vasopressin activates PKA, which phosphorylates AQP2, and this phosphoryla...
- Altered Chaperone-like Activity of alpha-Crystallins Promotes Cataractogenesis
[作者:Cheng, C; Xia, CH; Huang, QL; Ding, LL; Horwitz, J; Gong, XH,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- Despite the enormous number of studies demonstrating changes in the chaperone-like activity of alpha-crystallins in vitro, little is known about how these changes influence life-long lens transparency in vivo. Using the ...
- Dynamic Control of Glutamatergic Synaptic Input in the Spinal Cord by Muscarinic Receptor Subtypes Defined Using Knockout Mice
[作者:Chen, SR; Chen, H; Yuan, WX; Wess, J; Pan, HL,期刊:Journal of Biological Chemistry, 页码:889-898 , 文章类型: Article,,卷期:2010年285-52]
- Activation of muscarinic acetylcholine receptors (mAChRs) in the spinal cord inhibits pain transmission. At least three mAChR subtypes (M-2, M-3, andM(4)) are present in the spinal dorsal horn. However, it is not clear h...
- A Single Amino Acid in Human APOBEC3F Alters Susceptibility to HIV-1 Vif
[作者:Albin, JS; LaRue, RS; Weaver, JA; Brown, WL; Shindo, K; Harjes, E; Matsuo, H; Harris, RS,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- Human APOBEC3F (huA3F) potently restricts the infectivity of HIV-1 in the absence of the viral accessory protein virion infectivity factor (Vif). Vif functions to preserve viral infectivity by triggering the degradation ...
- HLA-DP, HLA-DQ, and HLA-DR Have Different Requirements for Invariant Chain and HLA-DM
[作者:van Lith, M; McEwen-Smith, RM; Benham, AM,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- The MHC is central to the adaptive immune response. The human MHC class II is encoded by three different isotypes, HLA-DR, -DQ, and -DP, each being highly polymorphic. In contrast to HLA-DR, the intracellular assembly an...
- Modification in Oxidative Stress, Inflammation, and Lipoprotein Assembly in Response to Hepatocyte Nuclear Factor 4 alpha Knockdown in Intestinal Epithelial Cells
[作者:Marcil, V; Seidman, E; Sinnett, D; Boudreau, F; Gendron, FP; Beaulieu, JF; Menard, D; Precourt, LP; Amre, D; Levy, E,期刊:Journal of Biological Chemistry, 页码:889-898 , 文章类型: Article,,卷期:2010年285-52]
- Hepatocyte nuclear factor 4 alpha (HNF4 alpha) is a nuclear transcription factor mainly expressed in the liver, intestine, kidney, and pancreas. Many of its hepatic and pancreatic functions have been described, but limit...
- Activation of AMP-activated Protein Kinase by Temozolomide Contributes to Apoptosis in Glioblastoma Cells via p53 Activation and mTORC1 Inhibition
[作者:Zhang, WB; Wang, Z; Shu, F; Jin, YH; Liu, HY; Wang, QJ; Yang, Y,期刊:Journal of Biological Chemistry, 页码:889-898 , 文章类型: Article,,卷期:2010年285-52]
- Methylating drugs such as temozolomide (TMZ) are widely used in the treatment of brain tumors including malignant glioblastoma. The mechanism of TMZ-induced glioblastoma cell death and apoptosis, however, is not fully un...
- The Ankyrin Repeat-rich Membrane Spanning (ARMS)/Kidins220 Scaffold Protein Is Regulated by Activity-dependent Calpain Proteolysis and Modulates Synaptic Plasticity
[作者:Wu, SH; Arevalo, JC; Neubrand, VE; Zhang, H; Arancio, O; Chao, MV,期刊:Journal of Biological Chemistry, 页码:889-898 , 文章类型: Article,,卷期:2010年285-52]
- The expression of forms of synaptic plasticity, such as the phenomenon of long-term potentiation, requires the activity-dependent regulation of synaptic proteins and synapse composition. Here we show that ARMS (ankyrin r...
- Cardiac Myosin Light Chain Kinase Is Necessary for Myosin Regulatory Light Chain Phosphorylation and Cardiac Performance in Vivo
[作者:Ding, PG; Huang, JA; Battiprolu, PK; Hill, JA; Kamm, KE; Stull, JT,期刊:Journal of Biological Chemistry, 页码:U161-U168 , 文章类型: Article,,卷期:2010年285-52]
- In contrast to studies on skeletal and smooth muscles, the identity of kinases in the heart that are important physiologically for direct phosphorylation of myosin regulatory light chain (RLC) is not known. A Ca2+/calmod...
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