- Suppressor of Cytokine Signaling 3 Inhibits LPS-induced IL-6 Expression in Osteoblasts by Suppressing CCAAT/Enhancer-binding Protein beta Activity
[作者:Yan, CG; Cao, J; Wu, M; Zhang, W; Jiang, T; Yoshimura, A; Gao, HW,期刊:Journal of Biological Chemistry, 页码:37227-37239 , 文章类型: Article,,卷期:2010年285-48]
- Suppressor of cytokine signaling 3 (SOCS3) is an important intracellular protein that inhibits cytokine signaling in numerous cell types and has been implicated in several inflammatory diseases. However, the expression a...
- InsP(3)R-associated cGMP Kinase Substrate Determines Inositol 1,4,5-Trisphosphate Receptor Susceptibility to Phosphoregulation by Cyclic Nucleotide-dependent Kinases
[作者:Masuda, W; Betzenhauser, MJ; Yule, DI,期刊:Journal of Biological Chemistry, 页码:37927-37938 , 文章类型: Article,,卷期:2010年285-48]
- Ca2+ release through inositol 1,4,5-trisphosphate receptors (InsP(3)R) can be modulated by numerous factors, including input from other signal transduction cascades. These events shape the spatio-temporal characteristics...
- Modulation of Energy Transfer Pathways between Mitochondria and Myofibrils by Changes in Performance of Perfused Heart
[作者:Vendelin, M; Hoerter, JA; Mateo, P; Soboll, S; Gillet, B; Mazet, JL,期刊:Journal of Biological Chemistry, 页码:37240-37250 , 文章类型: Article,,卷期:2010年285-48]
- In the heart, the energy supplied by mitochondria to myofibrils is continuously and finely tuned to the contraction requirement over a wide range of cardiac loads. This process is mediated both by the creatine kinase (CK...
- HNK-1 Epitope-carrying Tenascin-C Spliced Variant Regulates the Proliferation of Mouse Embryonic Neural Stem Cells
[作者:Yagi, H; Yanagisawa, M; Suzuki, Y; Nakatani, Y; Ariga, T; Kato, K; Yu, RK,期刊:Journal of Biological Chemistry, 页码:37293-37301 , 文章类型: Article,,卷期:2010年285-48]
- Neural stem cells (NSCs) possess high proliferative potential and the capacity for self-renewal with retention of multipotency to differentiate into neuronal and glial cells. NSCs are the source for neurogenesis during c...
- HIV-1 Vpr Loads Uracil DNA Glycosylase-2 onto DCAF1, a Substrate Recognition Subunit of a Cullin 4A-RING E3 Ubiquitin Ligase for Proteasome-dependent Degradation
[作者:Ahn, J; Vu, T; Novince, Z; Guerrero-Santoro, J; Rapic-Otrin, V; Gronenborn, AM,期刊:Journal of Biological Chemistry, 页码:37333-37341 , 文章类型: Article,,卷期:2010年285-48]
- The human immunodeficiency virus type 1 (HIV-1) accessory protein, Vpr, interacts with several host cellular proteins including uracil DNA glycosylase-2 (UNG2) and a cullin-RING E3 ubiquitin ligase assembly (CRL4(DCAF1))...
- An Ancient P-Loop GTPase in Rice Is Regulated by a Higher Plant-specific Regulatory Protein
[作者:Cheung, MY; Xue, Y; Zhou, LA; Li, MW; Sun, SSM; Lam, HM,期刊:Journal of Biological Chemistry, 页码:37359-37369 , 文章类型: Article,,卷期:2010年285-48]
- YchF is a subfamily of the Obg family in the TRAFAC class of P-loop GTPases. The wide distribution of YchF homologues in both eukarya and bacteria suggests that they are descendents of an ancient protein, yet their physi...
- Molecular Genetics Evidence for the in Vivo Roles of the Two Major NADPH-dependent Disulfide Reductases in the Malaria Parasite
[作者:Buchholz, K; Putrianti, ED; Rahlfs, S; Schirmer, RH; Becker, K; Matuschewski, K,期刊:Journal of Biological Chemistry, 页码:37388-37395 , 文章类型: Article,,卷期:2010年285-48]
- Malaria-associated pathology is caused by the continuous expansion of Plasmodium parasites inside host erythrocytes. To maintain a reducing intracellular milieu in an oxygen-rich environment, malaria parasites have evolv...
- Oxidative and Nitrosative Modifications of Tropoelastin Prevent Elastic Fiber Assembly in Vitro
[作者:Akhtar, K; Broekelmann, TJ; Miao, M; Keeley, FW; Starcher, BC; Pierce, RA; Mecham, RP; Adair-Kirk, TL,期刊:Journal of Biological Chemistry, 页码:37396-37404 , 文章类型: Article,,卷期:2010年285-48]
- Elastic fibers are extracellular structures that provide stretch and recoil properties of tissues, such as lungs, arteries, and skin. Elastin is the predominant component of elastic fibers. Tropoelastin (TE), the precurs...
- Statins Promote the Degradation of Extracellular Amyloid beta-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion
[作者:Tamboli, IY; Barth, E; Christian, L; Siepmann, M; Kumar, S; Singh, S; Tolksdorf, K; Heneka, MT; Lutjohann, D; Wunderlich, P; Walter, J,期刊:Journal of Biological Chemistry, 页码:37405-37414 , 文章类型: Article,,卷期:2010年285-48]
- Epidemiological studies indicate that intake of statins decrease the risk of developing Alzheimer disease. Cellular and in vivo studies suggested that statins might decrease the generation of the amyloid beta-peptide (A ...
- Cytoplasmic FANCA-FANCC Complex Interacts and Stabilizes the Cytoplasm-dislocalized Leukemic Nucleophosmin Protein (NPMc)
[作者:Du, W; Li, J; Sipple, J; Chen, JJ; Pang, QS,期刊:Journal of Biological Chemistry, 页码:37436-37444 , 文章类型: Article,,卷期:2010年285-48]
- Eight of the Fanconi anemia (FA) proteins form a core complex that activates the FA pathway. Some core complex components also form subcomplexes for yet-to-be-elucidated functions. Here, we have analyzed the interaction ...
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