- Potent neuroprotective role of novel melatonin derivatives for management of central neuropathy induced by acrylamide in rats
[作者:Ahmed, HH; Elmegeed, GA; El-Sayed, ESM; Abd-Elhalim, MM; Shousha, WG; Shafic, RW,期刊:European Journal of Medicinal Chemistry, 页码:5452-5459 , 文章类型: Article,,卷期:2010年45-11]
- Acrylamide (ACR) has been shown to be a neurotoxic agent for both laboratory animals and human. The present study aimed at synthesizing new functionalized melatonin derivatives bearing promising heterocyclic moiety that ...
- Synthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles
[作者:Vijesh, AM; Isloor, AM; Prabhu, V; Ahmad, S; Malladi, S,期刊:European Journal of Medicinal Chemistry, 页码:5460-5464 , 文章类型: Article,,卷期:2010年45-11]
- In the present study a series of novel 2,4-disubstituted thiazole derivatives containing substituted pyrazole moiety was synthesized by the reaction of 3-Aryl-1H-pyrazole-4-carbaldehyde thiosemicarbazone with 6-Bromo/H-3...
- Synthesis and characterization of a iodine-125-labeled pyrrolo[1,2-a]thieno[3,2-e] pyrazine and evaluation as a potential 5-HT4R SPECT tracer
[作者:Cailly, T; Dumas, N; Millet, P; Lemaitre, S; Fabis, F; Charnay, Y; Rault, S,期刊:European Journal of Medicinal Chemistry, 页码:5465-5467 , 文章类型: Article,,卷期:2010年45-11]
- In the aim to find new radiotracers for the in vivo imaging of 5-HT4 receptors by ultra-high resolution quantitative SPECT, we have developed the synthesis of a radioiodinated 5-HT4 ligand using an iododestannylation pro...
- The synthesis, structure and activity evaluation of pyrogallol and catechol derivatives as Helicobacter pylori urease inhibitors
[作者:Xiao, ZP; Ma, TW; Fu, WC; Peng, XC; Zhang, AH; Zhu, HL,期刊:European Journal of Medicinal Chemistry, 页码:5064-5070 , 文章类型: Article,,卷期:2010年45-11]
- Some pyrogallol and catechol derivatives were synthesized, and their urease inhibitory activity was evaluated by using acetohydroxamic acid (AHA), a well known Helicobacter pylori urease inhibitor, as positive control. T...
- Synthesis and anti-prion activity evaluation of aminoquinoline analogues
[作者:Macedo, B; Kaschula, CH; Hunter, R; Chaves, JAP; van der Merwe, JD; Silva, JL; Egan, TJ; Cordeiro, Y,期刊:European Journal of Medicinal Chemistry, 页码:5468-5473 , 文章类型: Article,,卷期:2010年45-11]
- Transmissible spongiform encephalopathies form a group of neurodegenerative diseases that affect humans and other mammals. They occur when the native prion protein is converted into an infectious isoform, the scrapie PrP...
- Synthesis of some p-toluenesulfonyl-hydrazinothiazoles and hydrazino-bis-thiazoles and their anticancer activity
[作者:Zaharia, V; Ignat, A; Palibrod, N; Ngameni, B; Kuete, V; Fokunang, CN; Moungang, ML; Ngadjui, BT,期刊:European Journal of Medicinal Chemistry, 页码:5080-5085 , 文章类型: Article,,卷期:2010年45-11]
- A series of novel p-toluenesulfonyl-hydrazinothiazoles and hydrazino-bis-thiazoles derivatives (2a-f,3a-f, and 5-8) were synthesized by initial condensation of p-toluenesulfonylthiosemicarbazide 1 with a series of alpha-...
- Novel structural insights for drug design of selective 5-HT2C inverse agonists from a ligand-biased receptor model
[作者:Renault, N; Gohier, A; Chavatte, P; Farce, A,期刊:European Journal of Medicinal Chemistry, 页码:5086-5099 , 文章类型: Article,,卷期:2010年45-11]
- Structure-based design of compounds targeting monoamine receptors, within the class-A G-protein coupled receptors, has been enriched by the recent crystallization of the beta 1 and beta 2 adrenoceptors. On the basis of l...
- Homology modeling and molecular dynamics of CYP1A1 and CYP2B1 to explore the metabolism of aryl derivatives by docking and experimental assays
[作者:Rosales-Hernandez, MC; Mendieta-Wejebe, JE; Trujillo-Ferrara, JG; Correa-Basurto, J,期刊:European Journal of Medicinal Chemistry, 页码:4845-4855 , 文章类型: Article,,卷期:2010年45-11]
- Since many drugs are metabolized by cytochrome P450 (CYP450), biotransformation studies using these enzymes are valuable in drug development. In this work, the biotransformation by CYP1A1 and CYP2B1 of two acetylcholines...
- Antimycobacterial and antitumor activities of Palladium(II) complexes containing isonicotinamide (isn): X-ray structure of trans-[Pd(N-3)(2)(isn)(2)]
[作者:de Souza, RA; Stevanato, A; Treu, O; Netto, AVG; Mauro, AE; Castellano, EE; Carlos, IZ; Pavan, FR; Leite, CQF,期刊:European Journal of Medicinal Chemistry, 页码:4863-4868 , 文章类型: Article,,卷期:2010年45-11]
- Complexes of the type trans-[PdX2(isn)(2)] {X = Cl (1), N-3 (2), SCN (3), NCO (4); isn = isonicotinamide} were synthesized and evaluated for in vitro antimycobacterial and antitumor activities. The coordination mode of t...
|