- Dopamine modulates synaptic plasticity in dendrites of rat and human dentate granule cells
[作者:Hamilton, TJ; Wheatley, BM; Sinclair, DB; Bachmann, M; Larkum, ME; Colmers, WF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18185-18190 , 文章类型: Article,,卷期:2010年107-42]
- The mechanisms underlying memory formation in the hippocampal network remain a major unanswered aspect of neuroscience. Although high-frequency activity appears essential for plasticity, salience for memory formation is ...
- Long-running German panel survey shows that personal and economic choices, not just genes, matter for happiness
[作者:Headey, B; Muffels, R; Wagner, GG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17922-17926 , 文章类型: Article,,卷期:2010年107-42]
- Psychologists and economists take contradictory approaches to research on what psychologists call happiness or subjective wellbeing, and economists call subjective utility. A direct test of the most widely accepted psych...
- Mimicking nature by codelivery of stimulant and inhibitor to create temporally stable and spatially restricted angiogenic zones
[作者:Yuen, WW; Du, NR; Chan, CH; Silva, EA; Mooney, DJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17933-17938 , 文章类型: Article,,卷期:2010年107-42]
- Nature frequently utilizes opposing factors to create a stable activator gradient to robustly control pattern formation. This study employs a biomimicry approach, by delivery of both angiogenic and antiangiogenic factors...
- SNARE tagging allows stepwise assembly of a multimodular medicinal toxin
[作者:Darios, F; Niranjan, D; Ferrari, E; Zhang, F; Soloviev, M; Rummel, A; Bigalke, H; Suckling, J; Ushkaryov, Y; Naumenko, N; Shakirzyanova, A; Giniatullin, R; Maywood, E; Hastings, M; Binz, T; Davletov, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18197-18201 , 文章类型: Article,,卷期:2010年107-42]
- Generation of supramolecular architectures through controlled linking of suitable building blocks can offer new perspectives to medicine and applied technologies. Current linking strategies often rely on chemical methods...
- Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction
[作者:Das, A; Durrant, D; Mitchell, C; Mayton, E; Hoke, NN; Salloum, FN; Park, MA; Qureshi, I; Lee, R; Dent, P; Kukreja, RC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18202-18207 , 文章类型: Article,,卷期:2010年107-42]
- We have shown that the potent phosphodiesterase-5 (PDE-5) inhibitor sildenafil (Viagra) induces a powerful effect on reduction of infarct size following ischemia/reperfusion injury and improvement of left ventricular dys...
- Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy
[作者:Kolishetti, N; Dhar, S; Valencia, PM; Lin, LQ; Karnik, R; Lippard, SJ; Langer, R; Farokhzad, OC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17939-17944 , 文章类型: Article,,卷期:2010年107-42]
- The genomic revolution has identified therapeutic targets for a plethora of diseases, creating a need to develop robust technologies for combination drug therapy. In the present work, we describe a self-assembled polymer...
- Nucleosome depletion at yeast terminators is not intrinsic and can occur by a transcriptional mechanism linked to 3 '-end formation
[作者:Fan, XC; Moqtaderi, Z; Jin, Y; Zhang, Y; Liu, XS; Struhl, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17945-17950 , 文章类型: Article,,卷期:2010年107-42]
- Genome-wide mapping of nucleosomes generated by micrococcal nuclease (MNase) suggests that yeast promoter and terminator regions are very depleted of nucleosomes, predominantly because their DNA sequences intrinsically d...
- Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity
[作者:Beekman, M; Nederstigt, C; Suchiman, HED; Kremer, D; van der Breggen, R; Lakenberg, N; Alemayehu, WG; de Craen, AJM; Westendorp, RGJ; Boomsma, DI; de Geus, EJC; Houwing-Duistermaat, JJ; Heijmans, BT; Slagboom, PE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18046-18049 , 文章类型: Article,,卷期:2010年107-42]
- A set of currently known alleles increasing the risk for coronary artery disease, cancer, and type 2 diabetes as identified by genome-wide association studies was tested for compatibility with human longevity. Here, we s...
- An atypical member of the light-harvesting complex stress-related protein family modulates diatom responses to light
[作者:Bailleul, B; Rogato, A; de Martino, A; Coesel, S; Cardol, P; Bowler, C; Falciatore, A; Finazzi, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18214-18219 , 文章类型: Article,,卷期:2010年107-42]
- Diatoms are prominent phytoplanktonic organisms that contribute around 40% of carbon assimilation in the oceans. They grow and perform optimally in variable environments, being able to cope with unpredictable changes in ...
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