- Structure-based development of a receptor activator of nuclear factor-kappa B ligand (RANKL) inhibitor peptide and molecular basis for osteopetrosis
[作者:Ta, HM; Nguyen, GTT; Jin, HM; Choi, J; Park, H; Kim, N; Hwang, HY; Kim, KK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20281-20286 , 文章类型: Article,,卷期:2010年107-47]
- The receptor activator of nuclear factor-kappa B (RANK) and its ligand RANKL, which belong to the tumor necrosis factor (TNF) receptor- ligand family, mediate osteoclastogenesis. The crystal structure of the RANKL ectodo...
- Structure of the bacteriophage T4 long tail fiber receptor-binding tip
[作者:Bartual, SG; Otero, JM; Garcia-Doval, C; Llamas-Saiz, AL; Kahn, R; Fox, GC; van Raaij, MJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20287-20292 , 文章类型: Article,,卷期:2010年107-47]
- Bacteriophages are the most numerous organisms in the biosphere. In spite of their biological significance and the spectrum of potential applications, little high-resolution structural detail is available on their recept...
- Sex difference in cell proliferation in developing rat amygdala mediated by endocannabinoids has implications for social behavior
[作者:Krebs-Kraft, DL; Hill, MN; Hillard, CJ; McCarthy, MM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20535-20540 , 文章类型: Article,,卷期:2010年107-47]
- The amygdala is a sexually dimorphic brain region critical for the regulation of social, cognitive, and emotional behaviors, but both the nature and the source of sex differences in the amygdala are largely unknown. We h...
- Impact of the human circadian system, exercise, and their interaction on cardiovascular function
[作者:Scheer, FAJL; Hu, K; Evoniuk, H; Kelly, EE; Malhotra, A; Hilton, MF; Shea, SA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20541-20546 , 文章类型: Article,,卷期:2010年107-47]
- The risk of adverse cardiovascular events peaks in the morning (approximate to 9:00 AM) with a secondary peak in the evening (approximate to 8:00 PM) and a trough at night. This pattern is generally believed to be caused...
- Dynamics of alpha-helical subdomain rotation in the intact maltose ATP-binding cassette transporter
[作者:Orelle, C; Alvarez, FJD; Oldham, ML; Orelle, A; Wiley, TE; Chen, J; Davidson, AL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20293-20298 , 文章类型: Article,,卷期:2010年107-47]
- ATP-binding cassette (ABC) transporters are powered by a nucleotide-binding domain dimer that opens and closes during cycles of ATP hydrolysis. These domains consist of a RecA-like subdomain and an a-helical subdomain th...
- Structural basis of oligomerization in septin-like GTPase of immunity-associated protein 2 (GIMAP2)
[作者:Schwefel, D; Frohlich, C; Eichhorst, J; Wiesner, B; Behlke, J; Aravind, L; Daumke, O,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20299-20304 , 文章类型: Article,,卷期:2010年107-47]
- GTPases of immunity-associated proteins (GIMAPs) are a distinctive family of GTPases, which control apoptosis in lymphocytes and play a central role in lymphocyte maturation and lymphocyte-associated diseases. To explore...
- Separate value comparison and learning mechanisms in macaque medial and lateral orbitofrontal cortex
[作者:Noonan, MP; Walton, ME; Behrens, TEJ; Sallet, J; Buckley, MJ; Rushworth, MFS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20547-20552 , 文章类型: Article,,卷期:2010年107-47]
- Uncertainty about the function of orbitofrontal cortex (OFC) in guiding decision-making may be a result of its medial (mOFC) and lateral (lOFC) divisions having distinct functions. Here we test the hypothesis that the mO...
- Genetically encoded dendritic marker sheds light on neuronal connectivity in Drosophila
[作者:Nicolai, LJJ; Ramaekers, A; Raemaekers, T; Drozdzecki, A; Mauss, AS; Yan, J; Landgraf, M; Annaert, W; Hassan, BA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20553-20558 , 文章类型: Article,,卷期:2010年107-47]
- In recent years, Drosophila melanogaster has emerged as a powerful model for neuronal circuit development, pathology, and function. A major impediment to these studies has been the lack of a genetically encoded, specific...
- tRNA(His) guanylyltransferase (THG1), a unique 3 '-5 ' nucleotidyl transferase, shares unexpected structural homology with canonical 5 '-3 ' DNA polymerases
[作者:Hyde, SJ; Eckenroth, BE; Smith, BA; Eberley, WA; Heintz, NH; Jackman, JE; Doublie, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20305-20310 , 文章类型: Article,,卷期:2010年107-47]
- All known DNA and RNA polymerases catalyze the formation of phosphodiester bonds in a 5' to 3'direction, suggesting this property is a fundamental feature of maintaining and dispersing genetic information. The tRNA(His) ...
- CpG methylation of half-CRE sequences creates C/EBP alpha binding sites that activate some tissue-specific genes
[作者:Rishi, V; Bhattacharya, P; Chatterjee, R; Rozenberg, J; Zhao, JF; Glass, K; Fitzgerald, P; Vinson, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20311-20316 , 文章类型: Article,,卷期:2010年107-47]
- DNA methylation of the cytosine in the CpG dinucleotide is typically associated with gene silencing. Genomic analyses have identified low CpG promoters that are both methylated and transcriptionally active, but the mecha...
- Tetrameric organization of vertebrate centromeric nucleosomes
[作者:Dimitriadis, EK; Weber, C; Gill, RK; Diekmann, S; Dalal, Y,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20317-20322 , 文章类型: Article,,卷期:2010年107-47]
- Mitosis ensures equal genome segregation in the eukaryotic lineage. This process is facilitated by microtubule attachment to each chromosome via its centromere. In centromeres, canonical histone H3 is replaced in nucleos...
- CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells
[作者:Jahnichen, S; Blanchetot, C; Maussang, D; Gonzalez-Pajuelo, M; Chow, KY; Bosch, L; De Vrieze, S; Serruys, B; Ulrichts, H; Vandevelde, W; Saunders, M; De Haard, HJ; Schols, D; Leurs, R; Vanlandschoot, P; Verrips, T; Smit, MJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20565-20570 , 文章类型: Article,,卷期:2010年107-47]
- The important family of G protein-coupled receptors has so far not been targeted very successfully with conventional monoclonal antibodies. Here we report the isolation and characterization of functional VHH-based immuno...
- Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth
[作者:Rogan, MP; Reznikov, LR; Pezzulo, AA; Gansemer, ND; Samuel, M; Prather, RS; Zabner, J; Fredericks, DC; McCray, PB; Welsh, MJ; Stoltz, DA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20571-20575 , 文章类型: Article,,卷期:2010年107-47]
- People with cystic fibrosis (CF) exhibit growth defects. That observation has been attributed, in part, to decreased insulin-like growth factor 1 (IGF1) levels, and the reduction has been blamed on malnutrition and pulmo...
- Climatic warming disrupts recurrent Alpine insect outbreaks
[作者:Johnson, DM; Buntgen, U; Frank, DC; Kausrud, K; Haynes, KJ; Liebhold, AM; Esper, J; Stenseth, NC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20576-20581 , 文章类型: Article,,卷期:2010年107-47]
- Climate change has been identified as a causal factor for diverse ecological changes worldwide. Warming trends over the last couple of decades have coincided with the collapse of long-term population cycles in a broad ra...
- Biomechanical analysis of gait adaptation in the nematode Caenorhabditis elegans
[作者:Fang-Yen, C; Wyart, M; Xie, J; Kawai, R; Kodger, T; Chen, S; Wen, QA; Samuel, ADT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20323-20328 , 文章类型: Article,,卷期:2010年107-47]
- To navigate different environments, an animal must be able to adapt its locomotory gait to its physical surroundings. The nematode Caenorhabditis elegans, between swimming in water and crawling on surfaces, adapts its lo...
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