- Unexpected heterogeneity due to recessive and de novo dominant mutations of GJB2 in an Iranian family with nonsyndromic hearing loss: Implication for genetic counseling
[作者:Mandieh, N; Shirkavand, A; Raeisi, M; Akbari, MT; Mustafa, T; Zeinali, S,期刊:Biochemical and Biophysical Research Communications, 页码:305-307 , 文章类型: Article,,卷期:2010年402-2]
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- Inflammatory cytokines regulate microRNA-155 expression in human retinal pigment epithelial cells by activating JAK/STAT pathway
[作者:Kutty, RK; Nagineni, CN; Samuel, W; Vijayasarathy, C; Hooks, JJ; Redmond, TM,期刊:Biochemical and Biophysical Research Communications, 页码:390-395 , 文章类型: Article,,卷期:2010年402-2]
- Inflammatory response of the retinal pigment epithelium plays a critical role in the pathogenesis of retinal degenerative diseases such as age-related macular degeneration. Our previous studies have shown that human reti...
- Ischemia-induced angiogenesis is impaired in aminopeptidase A deficient mice via down-regulation of HIF-1 alpha
[作者:Kubota, R; Numaguchi, Y; Ishii, M; Niwa, M; Okumura, K; Naruse, K; Murohara, T,期刊:Biochemical and Biophysical Research Communications, 页码:396-401 , 文章类型: Article,,卷期:2010年402-2]
- Aminopeptidase A (APA; EC 3.4.11.7) is a transmembrane metalloprotease with several functions in tumor angiogenesis. To investigate the role of APA in the process of ischemia-induced angiogenesis, we evaluated the cellul...
- Gene disruption of caspase-3 prevents MPTP-induced Parkinson's disease in mice
[作者:Yamada, M; Kida, K; Amutuhaire, W; Ichinose, F; Kaneki, M,期刊:Biochemical and Biophysical Research Communications, 页码:312-318 , 文章类型: Article,,卷期:2010年402-2]
- The development of Parkinson's disease is accompanied by concurrent activation of caspase-3 and apoptosis of dopaminergic neurons of human patients and rodent models. The role of caspase-3, a final executioner of apoptos...
- Combined use of bFGF and GDF-5 enhances the healing of medial collateral ligament injury
[作者:Saiga, K; Furumatsu, T; Yoshida, A; Masuda, S; Takihira, S; Abe, N; Ozaki, T,期刊:Biochemical and Biophysical Research Communications, 页码:329-334 , 文章类型: Article,,卷期:2010年402-2]
- Basic fibroblast growth factor (bFGF) and growth and differentiation factor (GDF)-5 stimulate the healing of medial collateral ligament (MCL) injury. However, the effect of isolated and combined use of bFGF/GDF-5 remains...
- Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits
[作者:Dergai, O; Novokhatska, O; Dergai, M; Skrypkina, I; Tsyba, L; Moreau, J; Rynditch, A,期刊:Biochemical and Biophysical Research Communications, 页码:408-413 , 文章类型: Article,,卷期:2010年402-2]
- Intersectin 1 (ITSN1) is an evolutionarily conserved adaptor protein involved in clathrin-mediated endocytosis, cellular signaling and cytoskeleton rearrangement. ITSN1 gene is located on human chromosome 21 in Down synd...
- Functional characterization of the zebrafish WHSC1-related gene, a homolog of human NSD2
[作者:Yamada-Okabe, T; Imamura, K; Kawaguchi, N; Sakai, H; Yamashita, M; Matsumoto, N,期刊:Biochemical and Biophysical Research Communications, 页码:335-339 , 文章类型: Article,,卷期:2010年402-2]
- Methylation of specific lysine residues of histone H3 and H4 has been reported to be important in the structuring of chromatin and for the transcription of certain genes. Proteins with SET domains have been shown to meth...
- The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and beta-adrenergically desensitized ventricular myocytes
[作者:El-Armouche, A; Wahab, A; Wittkopper, K; Schulze, T; Bottcher, F; Pohlmann, L; King, SB; DuMond, JF; Gerloff, C; Boger, RH; Eschenhagen, T; Carrier, L; Donzelli, S,期刊:Biochemical and Biophysical Research Communications, 页码:340-344 , 文章类型: Article,,卷期:2010年402-2]
- Contractile dysfunction and diminished response to p-adrenergic agonists are characteristics for failing hearts. Chemically donated nitroxyl (HNO) improves contractility in failing hearts and thus may have therapeutic po...
- PRIMA-1 cytotoxicity correlates with nucleolar localization and degradation of mutant p53 in breast cancer cells
[作者:Russo, D; Ottaggio, L; Penna, I; Foggetti, G; Fronza, G; Inga, A; Menichini, P,期刊:Biochemical and Biophysical Research Communications, 页码:345-350 , 文章类型: Article,,卷期:2010年402-2]
- PRIMA-1 has been identified as a compound that restores the transactivation function to mutant p53 and induces apoptosis in cells expressing mutant p53. Studies on subcellular distribution of the mutant p53 protein upon ...
- The E3 ubiquitin ligase WWP1 regulates Delta Np63-dependent transcription through Lys63 linkages
[作者:Peschiaroli, A; Scialpi, F; Bernassola, F; El Sherbini, E; Melino, G,期刊:Biochemical and Biophysical Research Communications, 页码:425-430 , 文章类型: Article,,卷期:2010年402-2]
- The transcription factor p63, a member of the p53 family, plays a crucial role in epithelial development and tumorigenesis through the regulation of epithelial progenitor cell proliferation, differentiation and apoptosis...
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