- Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice
[作者:Wang, F; Okamoto, Y; Inoki, I; Yoshioka, K; Du, W; Qi, X; Takuwa, N; Gonda, K; Yamamoto, Y; Ohkawa, R; Nishiuchi, T; Sugimoto, N; Yatomi, Y; Mitsumori, K; Asano, M; Kinoshita, M; Takuwa, Y,期刊:Journal of clinical investigation, 页码:3979-3995 , 文章类型: Article,,卷期:2010年120-11]
- Sphingosine-1-phosphate (S1P) is a biologically active sphingolipid that has pleiotropic effects in a variety of cell types including ECs, SMCs, and macrophages, all of which are central to the development of atheroscler...
- CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs
[作者:Li, W; Febbraio, M; Reddy, SP; Yu, DY; Yamamoto, M; Silverstein, RL,期刊:Journal of clinical investigation, 页码:3996-4006 , 文章类型: Article,,卷期:2010年120-11]
- CD36 is a membrane glycoprotein expressed on platelets, monocytes, macrophages, and several other cell types that was recently demonstrated to be involved in platelet activation in response to oxidized phospholipids, inc...
- Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice
[作者:Mavalli, MD; DiGirolamo, DJ; Fan, Y; Riddle, RC; Campbell, KS; van Groen, T; Frank, SJ; Sperling, MA; Esser, KA; Bamman, MM; Clemens, TL,期刊:Journal of clinical investigation, 页码:4007-4020 , 文章类型: Article,,卷期:2010年120-11]
- Skeletal muscle development, nutrient uptake, and nutrient utilization is largely coordinated by growth hormone (GH) and its downstream effectors, in particular, IGF-1. However, it is not clear which effects of GH on ske...
- The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration
[作者:Dentice, M; Marsili, A; Ambrosio, R; Guardiola, O; Sibilio, A; Paik, JH; Minchiotti, G; DePinho, RA; Fenzi, G; Larsen, PR; Salvatore, D,期刊:Journal of clinical investigation, 页码:4021-4030 , 文章类型: Article,,卷期:2010年120-11]
- The active thyroid hormone 3,5,3' triiodothyronine (T3) is a major regulator of skeletal muscle function. The deiodinase family of enzymes controls the tissue-specific activation and inactivation of the prohorrnone thyro...
- Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic beta cell death and diabetes
[作者:Fujimoto, K; Ford, EL; Tran, H; Wice, BM; Crosby, SD; Dorn, GW; Polonsky, KS,期刊:Journal of clinical investigation, 页码:4031-4039 , 文章类型: Article,,卷期:2010年120-11]
- Mutations in pancreatic duodenal homeobox (PDX1) are linked to human type 2 diabetes and maturity-onset diabetes of the young type 4. Consistent with this, Pdx1-haploinsufficient mice develop diabetes. Both apoptosis and...
- Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans
[作者:Bielesz, B; Sirin, Y; Si, H; Niranjan, T; Gruenwald, A; Ahn, S; Kato, H; Pullman, J; Gessler, M; Haase, VH; Susztak, K,期刊:Journal of clinical investigation, 页码:4040-4054 , 文章类型: Article,,卷期:2010年120-11]
- Chronic kidney disease is a leading cause of death in the United States. Tubulointerstitial fibrosis (TIF) is considered the final common pathway leading to end-stage renal disease (ESRD). Here, we used pharmacologic, ge...
- Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice
[作者:Papeta, N; Zheng, Z; Schon, EA; Brosel, S; Altintas, MM; Nasr, SH; Reiser, J; D'Agati, VD; Gharavi, AG,期刊:Journal of clinical investigation, 页码:4055-4064 , 文章类型: Article,,卷期:2010年120-11]
- Adriamycin (ADR) is a commonly used chemotherapeutic agent that also produces significant tissue damage. Mutations to mitochondrial DNA (mtDNA) and reductions in mtDNA copy number have been identified as contributors to ...
- Lipocalin 2 is essential for chronic kidney disease progression in mice and humans
[作者:Viau, A; El Karoui, K; Laouari, D; Burtin, M; Nguyen, C; Mori, K; Pillebout, E; Berger, T; Mak, TW; Knebelmann, B; Friedlander, G; Barasch, J; Terzi, F,期刊:Journal of clinical investigation, 页码:4065-4076 , 文章类型: Article,,卷期:2010年120-11]
- Mechanisms of progression of chronic kidney disease (CKD), a major health care burden, are poorly understood. EGFR stimulates CKD progression, but the molecular networks that mediate its biological effects remain unknown...
- Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2
[作者:Hiby, SE; Apps, R; Sharkey, AM; Farrell, LE; Gardner, L; Mulder, A; Claas, FH; Walker, JJ; Redman, CC; Morgan, L; Tower, C; Regan, L; Moore, GE; Carrington, M; Moffett, A,期刊:Journal of clinical investigation, 页码:4102-4110 , 文章类型: Article,,卷期:2010年120-11]
- Many common disorders of pregnancy are attributed to insufficient invasion of the uterine lining by trophoblast, fetal cells that are the major cell type of the placenta. Interactions between fetal trophoblast and matern...
- Homologous regions of autoantibody heavy chain complementarity-determining region 3 (H-CDR3) in patients with pemphigus cause pathogenicity
[作者:Yamagami, J; Payne, AS; Kacir, S; Ishii, K; Siegel, DL; Stanley, JR,期刊:Journal of clinical investigation, 页码:4111-4117 , 文章类型: Article,,卷期:2010年120-11]
- Pemphigus is a life-threatening autoimmune disease in which antibodies specific for desmogleins (Dsgs) cause loss of keratinocyte cell adhesion and blisters. In order to understand how antibodies cause pathogenicity and ...
- Serotonin receptor 1A-modulated phosphorylation of glycine receptor alpha 3 controls breathing in mice
[作者:Manzke, T; Niebert, M; Koch, UR; Caley, A; Vogelgesang, S; Hulsmann, S; Ponimaskin, E; Muller, U; Smart, TG; Harvey, RJ; Richter, DW,期刊:Journal of clinical investigation, 页码:4118-4128 , 文章类型: Article,,卷期:2010年120-11]
- Rhythmic breathing movements originate from a dispersed neuronal network in the medulla and pons. Here, we demonstrate that rhythmic activity of this respiratory network is affected by the phosphorylation status of the i...
- Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice
[作者:Berres, ML; Koenen, RR; Rueland, A; Zaldivar, MM; Heinrichs, D; Sahin, H; Schmitz, P; Streetz, KL; Berg, T; Gassler, N; Weiskirchen, R; Proudfoot, A; Weber, C; Trautwein, C; Wasmuth, HE,期刊:Journal of clinical investigation, 页码:4129-4140 , 文章类型: Article,,卷期:2010年120-11]
- Activation of hepatic stellate cells in response to chronic inflammation represents a crucial step in the development of liver fibrosis. However, the molecules involved in the interaction between immune cells and stellat...
- Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-alpha isoforms and promotes angiogenesis
[作者:Ghosh, G; Subramanian, IV; Adhikari, N; Zhang, XX; Joshi, HP; Basi, D; Chandrashekhar, YS; Hall, JL; Roy, S; Zeng, Y; Ramakrishnan, S,期刊:Journal of clinical investigation, 页码:4141-4154 , 文章类型: Article,,卷期:2010年120-11]
- Adaptive changes to oxygen availability are critical for cell survival and tissue homeostasis. Prolonged oxygen deprivation due to reduced blood flow to cardiac or peripheral tissues can lead to myocardial infarction and...
- Neutrophils responsive to endogenous IFN-beta regulate tumor angiogenesis and growth in a mouse tumor model (vol 120, pg 1151, 2010)
[作者:Jablonska, J; Leschner, S; Westphal, K; Lienenklaus, S; Weiss, S,期刊:Journal of clinical investigation, 页码:4163-4163 , 文章类型: Correction,,卷期:2010年120-11]
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