- Immune Responses Are Characterized by Specific Shared Immunoglobulin Peptides That Can Be Detected by Proteomic Techniques
[作者:VanDuijn, MM; Dekker, LJM; Zeneyedpour, L; Smitt, PAES; Luider, TM,期刊:Journal of Biological Chemistry, 页码:29247-29253 , 文章类型: Article,,卷期:2010年285-38]
- In the adaptive immune response, immunoglobulins develop that bind specifically to the antigens to which the organism was exposed. Immunoglobulins may bind to known or unknown antigens in a variety of diseases and have b...
- Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1
[作者:Pawelzik, SC; Uda, NR; Spahiu, L; Jegerschold, C; Stenberg, P; Hebert, H; Morgenstern, R; Jakobsson, PJ,期刊:Journal of Biological Chemistry, 页码:29254-29261 , 文章类型: Article,,卷期:2010年285-38]
- Microsomal prostaglandin E synthase-1 (MPGES1) is induced during an inflammatory reaction from low basal levels by pro-inflammatory cytokines and subsequently involved in the production of the important mediator of infla...
- Probing the Role of CXC Motif in Chemokine CXCL8 for High Affinity Binding and Activation of CXCR1 and CXCR2 Receptors
[作者:Joseph, PRB; Sarmiento, JM; Mishra, AK; Das, ST; Garofalo, RP; Navarro, J; Rajarathnam, K,期刊:Journal of Biological Chemistry, 页码:29262-29269 , 文章类型: Article,,卷期:2010年285-38]
- All chemokines share a common structural scaffold that mediate a remarkable variety of functions from immune surveillance to organogenesis. Chemokines are classified as CXC or CC on the basis of conserved cysteines, and ...
- Induction of Pluripotent Stem Cells from Human Third Molar Mesenchymal Stromal Cells
[作者:Oda, Y; Yoshimura, Y; Ohnishi, H; Tadokoro, M; Katsube, Y; Sasao, M; Kubo, Y; Hattori, K; Saito, S; Horimoto, K; Yuba, S; Ohgushi, H,期刊:Journal of Biological Chemistry, 页码:29270-29278 , 文章类型: Article,,卷期:2010年285-38]
- The expression of four transcription factors (OCT3/4, SOX2, KLF4, and MYC) can reprogram mouse as well as human somatic cells to induced pluripotent stem (iPS) cells. We generated iPS cells from mesenchymal stromal cells...
- The Epstein-Barr Virus-encoded G Protein-coupled Receptor BILF1 Hetero-oligomerizes with Human CXCR4, Scavenges G alpha(i) Proteins, and Constitutively Impairs CXCR4 Functioning
[作者:Nijmeijer, S; Leurs, R; Smit, MJ; Vischer, HF,期刊:Journal of Biological Chemistry, 页码:29632-29641 , 文章类型: Article,,卷期:2010年285-38]
- Cells express distinct G protein-coupled receptor (GPCR) subtypes on their surface, allowing them to react to a corresponding variety of extracellular stimuli. Cross-regulation between different ligand-GPCR pairs is esse...
- Activation of Integrins by Urea in Perfused Rat Liver
[作者:Reinehr, R; Gohlke, H; Sommerfeld, A; vom Dahl, S; Haussinger, D,期刊:Journal of Biological Chemistry, 页码:29348-29356 , 文章类型: Article,,卷期:2010年285-38]
- High concentrations of urea were shown to induce a paradoxical regulatory volume decrease response with K+ channel opening and subsequent hepatocyte shrinkage (Hallbrucker, C., vom Dahl, S., Ritter, M., Lang, F., and Hau...
- Smoothelin-like 1 Protein Regulates Myosin Phosphatase-targeting Subunit 1 Expression during Sexual Development and Pregnancy
[作者:Lontay, B; Bodoor, K; Weitzel, DH; Loiselle, D; Fortner, C; Lengyel, S; Zheng, DH; Devente, J; Hickner, R; Haystead, TAJ,期刊:Journal of Biological Chemistry, 页码:29357-29366 , 文章类型: Article,,卷期:2010年285-38]
- Pregnancy coordinately alters the contractile properties of both vascular and uterine smooth muscles reducing systemic blood pressure and maintaining uterine relaxation. The precise molecular mechanisms underlying these ...
- In Vitro Activities of the Multifunctional RNA Silencing Polymerase QDE-1 of Neurospora crassa
[作者:Aalto, AP; Poranen, MM; Grimes, JM; Stuart, DI; Bamford, DH,期刊:Journal of Biological Chemistry, 页码:29367-29374 , 文章类型: Article,,卷期:2010年285-38]
- QDE-1 is an RNA-and DNA-dependent RNA polymerase that has functions in the RNA silencing and DNA repair pathways of the filamentous fungus Neurospora crassa. The crystal structure of the dimeric enzyme has been solved, a...
- Differential Induction of Innate Immune Responses by Synthetic Lipid A Derivatives
[作者:Gaekwad, J; Zhang, YH; Zhang, W; Reeves, J; Wolfert, MA; Boons, GJ,期刊:Journal of Biological Chemistry, 页码:29375-29386 , 文章类型: Article,,卷期:2010年285-38]
- Recent studies have indicated that lipopolysaccharides (LPS) isolated from particular bacterial strains can bias innate immune responses toward different signal transduction pathways thereby eliciting unique patterns of ...
- Phosphorylation of a Novel Cytoskeletal Protein (RsmP) Regulates Rod-shaped Morphology in Corynebacterium glutamicum
[作者:Fiuza, M; Letek, M; Leiba, J; Villadangos, AF; Vaquera, J; Zanella-Cleon, I; Mateos, LM; Molle, V; Gil, JA,期刊:Journal of Biological Chemistry, 页码:29387-29397 , 文章类型: Article,,卷期:2010年285-38]
- Corynebacteria grow by wall extension at the cell poles, with DivIVA being an essential protein orchestrating cell elongation and morphogenesis. DivIVA is considered a scaffolding protein able to recruit other proteins a...
- Regulation of Integrin beta 1 Recycling to Lipid Rafts by Rab1a to Promote Cell Migration
[作者:Wang, CR; Yoo, Y; Fan, HP; Kim, E; Guan, KL; Guan, JL,期刊:Journal of Biological Chemistry, 页码:29398-29405 , 文章类型: Article,,卷期:2010年285-38]
- Rab1a is a member of the Rab family of small GTPases with a well characterized function in the regulation of vesicle trafficking from the endoplasmic reticulum to the Golgi apparatus and within Golgi compartments. The in...
- PDK1 Recruitment to the SHPS-1 Signaling Complex Enhances Insulin-like Growth Factor-I-stimulated AKT Activation and Vascular Smooth Muscle Cell Survival
[作者:Shen, XC; Xi, G; Radhakrishnan, Y; Clemmons, DR,期刊:Journal of Biological Chemistry, 页码:29416-29424 , 文章类型: Article,,卷期:2010年285-38]
- In vascular smooth muscle cells, exposed to hyperglycemia and insulin-like growth factor-I (IGF-I), SHPS-1 functions as a scaffold protein, and a signaling complex is assembled that leads to AKT activation. However, the ...
- Expression of Slug Is Regulated by c-Myb and Is Required for Invasion and Bone Marrow Homing of Cancer Cells of Different Origin
[作者:Tanno, B; Sesti, F; Cesi, V; Bossi, G; Ferrari-Amorotti, G; Bussolari, R; Tirindelli, D; Calabretta, B; Raschella, G,期刊:Journal of Biological Chemistry, 页码:29434-29445 , 文章类型: Article,,卷期:2010年285-38]
- In metastatic cancer cells, the process of invasion is regulated by several transcription factors that induce changes required for migration and resistance to apoptosis. Slug (SNAI2, Snail2) is involved in epithelial mes...
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