- Blocking O-Linked GlcNAc Cycling in Drosophila Insulin-producing Cells Perturbs Glucose-Insulin Homeostasis
[作者:Sekine, O; Love, DC; Rubenstein, DS; Hanover, JA,期刊:Journal of Biological Chemistry, 页码:38684-38691 , 文章类型: Article,,卷期:2010年285-49]
- A dynamic cycle of O-linked GlcNAc (O-GlcNAc) addition and removal is catalyzed by O-GlcNAc transferase and O-GlcNAcase, respectively, in a process that serves as the final step in a nutrient-driven "hexosamine-signaling...
- Aggregation of Detergent-insoluble Tau Is Involved in Neuronal Loss but Not in Synaptic Loss
[作者:Kimura, T; Fukuda, T; Sahara, N; Yamashita, S; Murayama, M; Mizoroki, T; Yoshiike, Y; Lee, B; Sotiropoulos, I; Maeda, S; Takashima, A,期刊:Journal of Biological Chemistry, 页码:38692-38699 , 文章类型: Article,,卷期:2010年285-49]
- Neurofibrillary tangles (NFTs), which consist of highly phosphorylated tau, are hallmarks of neurodegenerative diseases including Alzheimer disease (AD). In neurodegenerative diseases, neuronal dysfunction due to neurona...
- Serglycin-independent Release of Active Mast Cell Proteases in Response to Toxoplasma gondii Infection
[作者:Sawesi, O; Spillmann, D; Lunden, A; Wernersson, S; Abrink, M,期刊:Journal of Biological Chemistry, 页码:38005-38013 , 文章类型: Article,,卷期:2010年285-49]
- Earlier studies identified serglycin proteoglycan and its heparin chains to be important for storage and activity of mast cell proteases. However, the importance of serglycin for secretion and activity of mast cell prote...
- Rapamycin Inhibits Cytoskeleton Reorganization and Cell Motility by Suppressing RhoA Expression and Activity
[作者:Liu, L; Luo, Y; Chen, L; Shen, T; Xu, BS; Chen, WX; Zhou, HY; Han, XZ; Huang, SL,期刊:Journal of Biological Chemistry, 页码:38362-38373 , 文章类型: Article,,卷期:2010年285-49]
- The mammalian target of rapamycin (mTOR) functions in cells at least as two complexes, mTORC1 and mTORC2. Intensive studies have focused on the roles of mTOR in the regulation of cell proliferation, growth, and survival....
- The N348I Mutation at the Connection Subdomain of HIV-1 Reverse Transcriptase Decreases Binding to Nevirapine
[作者:Schuckmann, MM; Marchand, B; Hachiya, A; Kodama, EN; Kirby, KA; Singh, K; Sarafianos, SG,期刊:Journal of Biological Chemistry, 页码:38700-38709 , 文章类型: Article,,卷期:2010年285-49]
- The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase (RT) confers clinically significant resistance to both nucleoside and non-nucleoside RT inhibitors (NNRTIs) by mechanisms that are not well un...
- Interaction of Calcium-dependent Activator Protein for Secretion 1 (CAPS1) with the Class II ADP-ribosylation Factor Small GTPases Is Required for Dense-core Vesicle Trafficking in the trans-Golgi Network
[作者:Sadakata, T; Shinoda, Y; Sekine, Y; Saruta, C; Itakura, M; Takahashi, M; Furuichi, T,期刊:Journal of Biological Chemistry, 页码:38710-38719 , 文章类型: Article,,卷期:2010年285-49]
- Ca2+-dependent activator protein for secretion (CAPS) regulates exocytosis of catecholamine-or neuropeptide-containing dense-core vesicles (DCVs) at secretion sites, such as nerve terminals. However, large amounts of CAP...
- Requirement of TCF7L2 for TGF-beta-dependent Transcriptional Activation of the TMEPAI Gene
[作者:Nakano, N; Itoh, S; Watanabe, Y; Maeyama, K; Itoh, F; Kato, M,期刊:Journal of Biological Chemistry, 页码:38023-38033 , 文章类型: Article,,卷期:2010年285-49]
- The TGF-beta and Wnt pathways are involved in cell fate and tumorigenicity. A recent report indicated that a TGF-beta target gene, TMEPAI (transmembrane prostate androgen-induced RNA), is possibly also a downstream targe...
- Identification and Localization of a Lipase-like Acyltransferase in Phenylpropanoid Metabolism of Tomato (Solanum lycopersicum)
[作者:Teutschbein, J; Gross, W; Nimtz, M; Milkowski, C; Hause, B; Strack, D,期刊:Journal of Biological Chemistry, 页码:38374-38381 , 文章类型: Article,,卷期:2010年285-49]
- We have isolated an enzyme classified as chlorogenate: glucarate caffeoyltransferase (CGT) from seedlings of tomato (Solanum lycopersicum) that catalyzes the formation of caffeoylglucarate and caffeoylgalactarate using c...
- Homocysteine, Another Risk Factor for Alzheimer Disease, Impairs Apolipoprotein E3 Function
[作者:Minagawa, H; Watanabe, A; Akatsu, H; Adachi, K; Ohtsuka, C; Terayama, Y; Hosono, T; Takahashi, S; Wakita, H; Jung, CG; Komano, H; Michikawa, M,期刊:Journal of Biological Chemistry, 页码:38382-38388 , 文章类型: Article,,卷期:2010年285-49]
- Apolipoprotein E (apoE) epsilon 4 and hyperhomocysteinemia are risk factors for Alzheimer disease (AD). The dimerization of apoE3 by disulfide bonds between cysteine residues enhances apoE3 function to generate HDL. Beca...
- The Translocon Sec61 beta Localized in the Inner Nuclear Membrane Transports Membrane-embedded EGF Receptor to the Nucleus
[作者:Wang, YN; Yamaguchi, H; Huo, LF; Du, Y; Lee, HJ; Lee, HH; Wang, HM; Hsu, JM; Hung, MC,期刊:Journal of Biological Chemistry, 页码:38720-38729 , 文章类型: Article,,卷期:2010年285-49]
- Accumulating evidence indicates that endocytosis plays an essential role in the nuclear transport of the ErbB family members, such as epidermal growth factor receptor (EGFR) and ErbB-2. Nevertheless, how full-length rece...
- Cellular Abundance of Mps1 and the Role of Its Carboxyl Terminal Tail in Substrate Recruitment
[作者:Sun, TT; Yang, XM; Wang, W; Zhang, XJ; Xu, QB; Zhu, SC; Kuchta, R; Chen, GJ; Liu, XD,期刊:Journal of Biological Chemistry, 页码:38730-38739 , 文章类型: Article,,卷期:2010年285-49]
- Mps1 is a protein kinase that regulates normal mitotic progression and the spindle checkpoint in response to spindle damage. The levels of Mps1 are relatively low in cells during interphase but elevated in mitosis or upo...
- 14-3-3 zeta mediates resistance of diffuse large B cell lymphoma to an anthracycline-based chemotherapeutic regimen (vol 284, pg 22379, 2009)
[作者:Maxwell, SA; Li, ZG; Jaye, D; Ballard, S; Ferrell, J; Fu, HA,期刊:Journal of Biological Chemistry, 页码:38740-38740 , 文章类型: Correction,,卷期:2010年285-49]
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