A high-boiling, fluorous-organic hybrid ether, F-626, was tested for use in thermal retro-aldol reactions and found to be an excellent reaction medium in view of the ease of separation from the product by fluorous/organi...
Combination of a base, ethoxymethylene malonates, and alpha-bromoacetamides was used to reach structurally diverse alpha-alkoxy-gamma-lactams via a direct aza-MIRC sequence in excellent yields. Subsequent acidic treatmen...