- Synthesis, DNA-binding, photocleavage, cytotoxicity and antioxidant activity of ruthenium (II) polypyridyl complexes
[作者:Liu, YJ; Zeng, CH; Huang, HL; He, LX; Wu, FH,期刊:European Journal of Medicinal Chemistry, 页码:564-571 , 文章类型: Article,,卷期:2010年45-2]
- Two new ligands maip (1a), paip (1b) with their ruthenium (II) complexes [Ru(bpy)(2)(maip)](ClO4)(2) (2a) and [Ru(bpy)(2)(paip)](ClO4)(2) (2b) have been synthesized and characterized. The results show that complexes 2a a...
- Anti-oxidant and anti-bacterial activities of novel N '-arylmethylidene-2-(3, 4-dimethyl-5, 5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-2(4H)-yl) acetohydrazides
[作者:Ahmad, M; Siddiqui, HL; Zia-Ur-Rehman, M; Parvez, M,期刊:European Journal of Medicinal Chemistry, 页码:698-704 , 文章类型: Article,,卷期:2010年45-2]
- A series of potential anti-oxidant and anti-bacterial N'-arylmethylidene-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-2(4H)-yl)acetohydrazides was synthesized in a facile way starting from commercially ava...
- Synthesis and cytotoxic evaluation of beta-alkyl or beta-aryl-delta-methyl-alpha-methylene-delta-lactones. Comparison with the corresponding gamma-lactones
[作者:Albrecht, L; Wojciechowski, J; Albrecht, A; Wolf, WM; Janecka, A; Studzian, K; Krajewska, U; Rozalski, M; Janecki, T; Krawczyk, H,期刊:European Journal of Medicinal Chemistry, 页码:710-718 , 文章类型: Article,,卷期:2010年45-2]
- We present a simple and general strategy for the synthesis of beta,delta-disubstituted-alpha-methylene-delta-lactones starting from easily available tert-butyl 2-(diethoxyphosphoryl)alk-2-enoates. The elaborated syntheti...
- Radiosynthesis and radiopharmacological evaluation of cyclin-dependent kinase 4 (Cdk4) inhibitors
[作者:Koehler, L; Graf, F; Bergmann, R; Steinbach, J; Pietzsch, J; Wuest, F,期刊:European Journal of Medicinal Chemistry, 页码:727-737 , 文章类型: Article,,卷期:2010年45-2]
- Tumor cells are characterized by their loss of growth control resulting from alterations in regulating pathways of the cell cycle, such as a deregulated cyclin-dependent kinase (Cdk) activity and/or Cdk expression. Appro...
- Novel quinolines and pyrimido[4,5-b]quinolines bearing biologically active sulfonamide moiety as a new class of antitumor agents
[作者:Alqasoumi, SI; Al-Taweel, AM; Alafeefy, AM; Noaman, E; Ghorab, MM,期刊:European Journal of Medicinal Chemistry, 页码:738-744 , 文章类型: Article,,卷期:2010年45-2]
- Some novel quinolines and pyrimido[4,5-b]quinolines have been synthesized. The structures of which were confirmed by elemental analyses and spectral data. All the target compounds were subjected to in-vitro antitumor act...
- Efficient microwave combinatorial synthesis of novel indolic arylpiperazine derivatives as serotoninergic ligands
[作者:Frecentese, F; Fiorino, F; Perissutti, E; Severino, B; Magli, E; Esposito, A; De Angelis, F; Massarelli, P; Nencini, C; Viti, B; Santagada, V; Caliendo, G,期刊:European Journal of Medicinal Chemistry, 页码:752-759 , 文章类型: Article,,卷期:2010年45-2]
- An easy and convenient microwave-assisted synthesis of a small library of indolic arylpiperazine derivatives is described. Parallel and mixed pool combinatorial methods are reported and compared. The described reactions ...
- Asymmetrically substituted cationic indole- and fluorene porphyrins inhibit tumor proliferation in small intestinal neuroendocrine tumors and medullary thyroid carcinomas
[作者:Haeubl, M; Schuerz, S; Svejda, B; Reith, LM; Gruber, B; Pfragner, R; Schoefberger, W,期刊:European Journal of Medicinal Chemistry, 页码:760-773 , 文章类型: Article,,卷期:2010年45-2]
- In this study we demonstrate anticancer activity of novel fully water soluble cationic porphyrins. The two cationic porphyrins 5,10,15-tris(N-methylpyridinium-4-yl)-20-[1-phenyl-4-(3-N-phenylsulfonylindolyl)]-21H,23H-por...
- Metal-based biologically active agents: Synthesis, characterization, antibacterial and antileukemia activity evaluation of Cu(II), V(IV) and Ni(II) complexes with antipyrine-derived compounds
[作者:Rosu, T; Negoiu, M; Pasculescu, S; Pahontu, E; Poirier, D; Gulea, A,期刊:European Journal of Medicinal Chemistry, 页码:774-781 , 文章类型: Article,,卷期:2010年45-2]
- The paper presents the synthesis of complex combinations of Cu(II), V(IV) and Ni(II) with Schiff bases obtained through the condensation of 4-amino-1,5-dimethyl-2-phenyl-1H-3-pyrazol-3(2H)-one (anti-pyrine) with 2-hydrox...
- 8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists
[作者:Ivachtchenko, AV; Mitkin, OD; Tkachenko, SE; Okun, IM; Kysil, VM,期刊:European Journal of Medicinal Chemistry, 页码:782-789 , 文章类型: Article,,卷期:2010年45-2]
- A series of novel 8-sulfonyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles (THPI) has been synthesized and their ability to interact with 5-HT6 receptors evaluated in cell-based and radioligand binding assays. A...
- Cytotoxic activity of 3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and 4-oxo-4H-chromene-3-carbothioic acid N-phenylamides
[作者:Raj, T; Bhatia, RK; Kapur, A; Sharma, M; Saxena, AK; Ishar, MPS,期刊:European Journal of Medicinal Chemistry, 页码:790-794 , 文章类型: Article,,卷期:2010年45-2]
- 6/6,7-Substituted-3-formylchromones (8a-g) were reacted with 2 equivalents thiobenzamide (9) in refluxing toluene to furnish substituted -3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones (10a-g) in high yields. Simila...
- Synthesis and inhibitory activity against human monoamine oxidase of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1H)-pyrazole derivatives
[作者:Chimenti, F; Carradori, S; Secci, D; Bolasco, A; Bizzarri, B; Chimenti, P; Granese, A; Yanez, M; Orallo, F,期刊:European Journal of Medicinal Chemistry, 页码:800-804 , 文章类型: Article,,卷期:2010年45-2]
- A series of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1H)-pyrazole derivatives has been synthesized and assayed for their ability to inhibit the activity of the A and B isoforms of human monoamine oxidase (hMAO). ...
- Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors
[作者:Debdab, M; Renault, S; Lozach, O; Meijer, L; Paquin, L; Carreaux, F; Bazureau, JP,期刊:European Journal of Medicinal Chemistry, 页码:805-810 , 文章类型: Article,,卷期:2010年45-2]
- New derivatives of the marine alkaloid leucettamine B were prepared in five steps with overall yields ranging from 23 to 30%. The key step of our strategy has been the sulfur/nitrogen displacement under solvent-free micr...
|