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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共54条记录   Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective [作者：Abadi, AH; Gary, BD; Tinsley, HN; Piazza, GA; Abdel-Halim, M,期刊：European Journal of Medicinal Chemistry, 页码：1278-1286 , 文章类型： Article，,卷期：2010年45-4] The synthesis of novel tadalafil analogues in which the benzodioxole moiety is replaced by 2-bromophenyl; the chiral carbons swing from R,R to R,S, S,R and S,S; the piperazinedione ring is maintained or reduced to the 5-... Synthesis, characterization, and biocide properties of semicarbazide-formaldehyde resin and its polymer metal complexes [作者：Nishat, N; Ahamad, T; Alshehri, SM; Parveen, S,期刊：European Journal of Medicinal Chemistry, 页码：1287-1294 , 文章类型： Article，,卷期：2010年45-4] Semicarbazide formaldehyde resin (SFRs) was prepared by the condensation of semicarbazide with formaldehyde in an acidic medium and its polymer metal complexes were prepared with transition metal ions. All the synthesize... Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn-7-GMP [作者：Jia, Y; Chiu, TL; Amin, EA; Polunovsky, V; Bitterman, PB; Wagner, CR,期刊：European Journal of Medicinal Chemistry, 页码：1304-1313 , 文章类型： Article，,卷期：2010年45-4] Aberrant regulation of cap-dependent translation has been frequently observed in the development of cancer. Association of the cap-binding protein eIF4E with N-7-methylated guanosine capped mRNA is the rate limiting step... New dimeric cyclodiphosph(V)azane complexes of Cr(III), Co(II), Ni(II), Cu(II), and Zn(II): Preparation, characterization and biological activity studies [作者：Alaghaz, ANMA; Ammar, RA,期刊：European Journal of Medicinal Chemistry, 页码：1314-1322 , 文章类型： Article，,卷期：2010年45-4] The complexes of type [CrLCl](2)center dot 3.5H(2)O and [ML(H2O)](2 center dot)nH(2)O in which M = Co(II); n = 1, Ni(II); n = 4, Cu(II); n = 0.5 and Zn(II); n = 2 ions and L is 1,3-dimethy1-2,4-dioxo-2',4'-bis(2iminothio... Synthesis, characterization and biological evaluation of some thiourea derivatives bearing benzothiazole moiety as potential antimicrobial and anticancer agents [作者：Saeed, S; Rashid, N; Jones, PG; Ali, M; Hussain, R,期刊：European Journal of Medicinal Chemistry, 页码：1323-1331 , 文章类型： Article，,卷期：2010年45-4] Five series of thiourea derivatives bearing benzothiazole moiety (20 compounds) were efficiently synthesized and evaluated for antimicrobial and anticancer activities. The results indicated that the compounds possessed a... Antihyperglycemic activity of naphthylchalcones [作者：Damazio, RG; Zanatta, AP; Cazarolli, LH; Chiaradia, LD; Mascarello, A; Nunes, RJ; Yunes, RA; Silva, FRMB,期刊：European Journal of Medicinal Chemistry, 页码：1332-1337 , 文章类型： Article，,卷期：2010年45-4] The purpose of the present work was to investigate, following previous works, naphthylchalcones as antihyperglycemic agent in glucose loaded animal model, insulin secretion as well as the action of these compounds on glu... Synthesis and antimicrobial activities of some new thiazole and pyrazole derivatives based on 4,5,6,7-tetrahydrobenzothiophene moiety [作者：Gouda, MA; Berghot, MA; El-Ghani, GEA; Khalil, AM,期刊：European Journal of Medicinal Chemistry, 页码：1338-1345 , 文章类型： Article，,卷期：2010年45-4] 2-(5-oxothiazolidinone)-cyanoacetamido derivative 3 was prepared in two steps by reaction of 2(2-cyano-acetylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxamide (1) with phenyl isothiocyanate and chloroacetyl chlor... Synthesis, structure and affinity of novel 3-alkoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-ones for CNS central and peripheral benzodiazepine receptors [作者：Andronati, S; Semenishyna, E; Pavlovsky, V; Simonov, Y; Makan, S; Boyko, I; Burenkova, N; Gdaniec, M; Cardinael, P; Bouillon, JP; Mazepa, A,期刊：European Journal of Medicinal Chemistry, 页码：1346-1351 , 文章类型： Article，,卷期：2010年45-4] A series of novel 3-alkoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-ones (7-15) was synthesized and their in vitro affinity for both the central benzodiazepine receptor (CBR) and the peripheral benzodiazepine receptor (PBR) of... MIA-QSAR coupled to principal component analysis-adaptive neuro-fuzzy inference systems (PCA-ANFIS) for the modeling of the anti-HIV reverse transcriptase activities of TIBO derivatives [作者：Goodarzi, M; Freitas, MP,期刊：European Journal of Medicinal Chemistry, 页码：1352-1358 , 文章类型： Article，,卷期：2010年45-4] The activities of a series of HIV reverse transcriptase inhibitor TIBO derivatives were recently modeled by using genetic function approximation (GFA) and artificial neural networks (ANN) on topological, structural, elec... Design, synthesis and biological evaluation of indane-2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as beta-amyloid aggregation inhibitors [作者：Catto, M; Aliano, R; Carotti, A; Cellamare, S; Palluotto, F; Purgatorio, R; De Stradis, A; Campagna, F,期刊：European Journal of Medicinal Chemistry, 页码：1359-1366 , 文章类型： Article，,卷期：2010年45-4] Biological screening of (hetero)aromatic compounds allowed the identification of some novel inhibitors of A beta(1-40) aggregation, bearing indane and indole rings as common scaffolds. Molecular decoration of lead compou... Physicochemical characterization of neuroleptics. Relative stability of 7-and 9-hydroxyrisperidones and their protonated forms in gas phase and in solution [作者：Millefiori, S; Alparone, A,期刊：European Journal of Medicinal Chemistry, 页码：1367-1373 , 文章类型： Article，,卷期：2010年45-4] Conventional ab initio and DFT-B3LYP calculations have been used to investigate on molecular conformation, dipole moments, intramolecular hydrogen bond and relative energies of 9-hydroxy and 7-hydroxyrisperidone metaboli... New isatin derivatives with antioxidant activity [作者：Andreani, A; Burnelli, S; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Varoli, L; Cremonini, MA; Placucci, G; Cervellati, R; Greco, E,期刊：European Journal of Medicinal Chemistry, 页码：1374-1378 , 文章类型： Article，,卷期：2010年45-4] The reaction between isatin and 2,5-dimethoxyaniline is described. The main product was identified as 3,3-bis(4-amino-2,5-dimethoxyphenyl)-1,3-dihydroindol-2-one. The antioxidant activity of the compounds isolated was ev... The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1) [作者：Nittoli, T; Dushin, RG; Ingalls, C; Cheung, K; Floyd, MB; Fraser, H; Olland, A; Hu, YB; Grosu, G; Han, X; Arndt, K; Guo, B; Wissner, A,期刊：European Journal of Medicinal Chemistry, 页码：1379-1386 , 文章类型： Article，,卷期：2010年45-4] A series of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c] [2,7]naphthyridin-4-ylamine-based inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1) has been identified. Several examples appear to be potent an... InChI-based optimal descriptors: QSAR analysis of fullerene[C60]-based HIV-1 PR inhibitors by correlation balance [作者：Toropov, AA; Toropova, AP; Benfenati, E; Leszczynska, D; Leszczynski, J,期刊：European Journal of Medicinal Chemistry, 页码：1387-1394 , 文章类型： Article，,卷期：2010年45-4] The International Chemical Identifier (InChI) has been used to construct InChI-based optimal descriptors to model the binding affinity for fullerene[C60]-based inhibitors of human immunodeficiency virus type 1 aspartic p... Synthesis of 1-benzyl-3-(5-hydroxymethyl-2-furyl)selenolo[3,2-c]pyrazole derivatives as new anticancer agents [作者：Chou, LC; Huang, LJ; Hsu, MH; Fang, MC; Yang, JS; Zhuang, SH; Lin, HY; Lee, FY; Teng, CM; Kuo, SC,期刊：European Journal of Medicinal Chemistry, 页码：1395-1402 , 文章类型： Article，,卷期：2010年45-4] As part of our continuing search for potential anticancer drug candidates among YC-1 analogs, 1,3-disubstituted selenolo[3,2-c]pyrazole derivatives were synthesized and evaluated for their cytotoxicity against NCI-H226 n... Synthesis and anti-inflammatory activity of novel (substituted)benzylidene acetone oxime ether derivatives: Molecular modeling study [作者：El-Gamal, MI; Bayomi, SM; El-Ashry, SM; Said, SA; Abdel-Aziz, AAM; Abdel-Aziz, NI,期刊：European Journal of Medicinal Chemistry, 页码：1403-1414 , 文章类型： Article，,卷期：2010年45-4] Herein, we report the design, synthesis, and pharmacological properties of a series of substituted benzylidene acetone oxime ether derivatives from the corresponding oxime derivatives. All the newly synthesized compounds...