- Synthesis and biological evaluation of some pyrazolylpyrazolines as anti-inflammatory-antimicrobial agents
[作者:Sharma, PK; Kumar, S; Kumar, P; Kaushik, P; Kaushik, D; Dhingra, Y; Aneja, KR,期刊:European Journal of Medicinal Chemistry, 页码:2650-2655 , 文章类型: Article,,卷期:2010年45-6]
- A new series of pyrazolylpyrazolines (5a-k) was synthesized by the reaction of appropriate chalcones (3a-k) with 4-hydrazinobenzenesulfonamide hydrochloride (4) in ethanol. All the newly synthesized target compounds (5a-...
- Synthesis, evaluation and computational studies on a series of acetophenone based 1-(aryloxypropyl)-4-(chloroaryl) piperazines as potential atypical antipsychotics
[作者:Bali, A; Sharma, K; Bhalla, A; Bala, S; Reddy, D; Singh, A; Kumar, A,期刊:European Journal of Medicinal Chemistry, 页码:2656-2662 , 文章类型: Article,,卷期:2010年45-6]
- A series of 1-(aryloxypropyl)-4-(chloroaryl) piperazines have been synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced mesh climbing and stereotypy assays in mice. Th...
- Lipophilicity of novel antitumour and analgesic active 8-aryl-2,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazine-3,4-dione derivatives determined by reversed-phase HPLC and computational methods
[作者:Sztanke, K; Markowski, W; Swieboda, R; Polak, B,期刊:European Journal of Medicinal Chemistry, 页码:2644-2649 , 文章类型: Article,,卷期:2010年45-6]
- Eight novel antitumour and analgesic active 8-aryl-2,6,7,8-tetrahydrounisdazo[2,1-c][1,2,4]triazine-3,4-diones (1-8) have been obtained as a bloactive set of substances and their lipophilicity has been studied. The log k...
- Synthesis and evaluation of 9-benzylideneamino derivatives of homocamptothecin as potent inhibitors of DNA topoisomerase I
[作者:Guo, W; Miao, ZY; Sheng, CQ; Yao, JZ; Feng, H; Zhang, WN; Zhu, LJ; Liu, WF; Cheng, PF; Zhang, J; Che, XY; Wang, WY; Luo, C; Xu, YL,期刊:European Journal of Medicinal Chemistry, 页码:2223-2228 , 文章类型: Article,,卷期:2010年45-6]
- A series of novel 9-benzylideneamino derivatives of homocamptothecin were synthesized via Friedlaender cyclization from our obtained intermediate 5. All the compounds were evaluated for in vitro cytotoxicity against thre...
- Synthesis, antiproliferative, acute toxicity and assessment of antiandrogenic activities of some newly synthesized steroidal lactams
[作者:Dhingra, N; Bhardwaj, TR; Mehta, N; Mukhopadhyay, T; Kumar, A; Kumar, M,期刊:European Journal of Medicinal Chemistry, 页码:2229-2236 , 文章类型: Article,,卷期:2010年45-6]
- The 17-oxo-17a-aza-D-homo-5-androsten-3 beta-yl esters (13-22) were synthesized from commercially available (25R)-5-spirosten-3 beta-ol (Diosgenin) (6) as starting material. The synthesized compounds were evaluated for t...
- Guaiane sesquiterpenes from seaweed Ulva fasciata Delile and their antibacterial properties
[作者:Chakraborty, K; Lipton, AP; Paulraj, R; Chakraborty, RD,期刊:European Journal of Medicinal Chemistry, 页码:2237-2244 , 文章类型: Article,,卷期:2010年45-6]
- Two new guaiane sesquiterpene derivatives, guai-2-en-10 alpha-ol (1) and guai-2-en-10 alpha-methanol (2), were chromatographically purified as major constituents of the CHCl3/CH3OH (1.1, v/v) soluble fraction of Ulva fas...
- Design, synthesis and determination of antifungal activity of 5(6)-substituted benzotriazoles
[作者:Patel, PD; Patel, MR; Kocsis, B; Kocsis, E; Graham, SM; Warren, AR; Nicholson, SM; Billack, B; Fronczek, FR; Talele, TT,期刊:European Journal of Medicinal Chemistry, 页码:2214-2222 , 文章类型: Article,,卷期:2010年45-6]
- In an effort to find inhibitors that are effective against both Candida and Aspergillus spp., a series of 5(6)-(un)substituted benzotriazole analogs, represented by compounds 3a-3h and 3b'-3f', were prepared using a crys...
- Synthesis of some 5-phenylisoxazole-3-carboxylic acid derivatives as potent xanthine oxidase inhibitors
[作者:Wang, SJ; Yan, JF; Wang, J; Chen, JR; Zhang, TJ; Zhao, Y; Xue, MX,期刊:European Journal of Medicinal Chemistry, 页码:2663-2670 , 文章类型: Article,,卷期:2010年45-6]
- A number of 5-phenylisoxazole-3-carboxylic acid derivatives (5a-e, 11a-e) were synthesized and analyzed for their ability to inhibit xanthine oxidase. Most of the compounds exhibited potency levels in the micromolar/subm...
- Novel bis-phenanthridine derivatives with easily tunable linkers, study of their interactions with DNA and screening of antiproliferative activity
[作者:Duksi, M; Baretic, D; Caplar, V; Piantanida, I,期刊:European Journal of Medicinal Chemistry, 页码:2671-2676 , 文章类型: Article,,卷期:2010年45-6]
- Series of novel peptide-bridged bis-phenanthridine derivatives as well as corresponding monomers were prepared by solid phase peptide synthesis, which allowed easy and fast tuning of compound properties. Interactions of ...
- Design, synthesis, characterization, and antibacterial activity of {5-chloro-2-[(3-substitutedphenyl-1,2,4-oxadiazol-5-yl)-methoxy]-phenyl}-(phenyl)-methanones
[作者:Rai, NP; Narayanaswamy, VK; Govender, T; Manuprasad, BK; Shashikanth, S; Arunachalam, PN,期刊:European Journal of Medicinal Chemistry, 页码:2677-2682 , 文章类型: Article,,卷期:2010年45-6]
- In the present investigation, a series of novel {5-chloro-2-[(3-(substitutedphenyl)-1,2,4-oxadiazol-5-yl)-methoxy]-phenyl}-(phenyl)-methanones (3a-i) have been synthesized from 5-(chloromethyl)-3-sub-stitutedphenyl-1,2,4...
- First biological evaluation of developed 3-benzyloxyfluorenes as novel class of MDR modulators
[作者:Krug, M; Voigt, B; Baumert, C; Lupken, R; Molnar, J; Hilgeroth, A,期刊:European Journal of Medicinal Chemistry, 页码:2683-2688 , 文章类型: Article,,卷期:2010年45-6]
- A series of 3-benzyloxy-1-aza-9-oxafluorenes has been synthesized and biologically evaluated as novel MDR modulators. The concentration dependent inhibition of the efflux pump ABCB1 (P-glycoprotein) has been characterize...
- Scavenging activity of aminoantipyrines against hydroxyl radical
[作者:Santos, PMP; Antunes, AMM; Noronha, J; Fernandes, E; Vieira, AJSC,期刊:European Journal of Medicinal Chemistry, 页码:2258-2264 , 文章类型: Article,,卷期:2010年45-6]
- The pyrazolone derivatives antipyrine and 4-(N,N-dimethyl)-aminoantipyrine (aminopyrine) have long been used as analgesic, antipyretic and anti-inflammatory drugs. However, in spite of its recognized therapeutic benefits...
- Synthesis and cytotoxicity evaluation of (tetrahydro-beta-carboline)-1,3,5-triazine hybrids as anticancer agents
[作者:Kumar, R; Gupta, L; Pal, P; Khan, S; Singh, N; Katiyar, SB; Meena, S; Sarkar, J; Sinha, S; Kanaujiya, JK; Lochab, S; Trivedi, AK; Chauhan, PMS,期刊:European Journal of Medicinal Chemistry, 页码:2265-2276 , 文章类型: Article,,卷期:2010年45-6]
- A series of tetrahydro-beta-carbolines and 1,3,5-triazine hybrids have been synthesized and evaluated for their cytotoxicity against a panel of eight human cancer cell lines and normal human fibroblasts (NIH3T3). It led ...
- Synthesis and pharmacological evaluation of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives as anti-inflammatory and analgesic agents
[作者:Gaba, M; Singh, D; Singh, S; Sharma, V; Gaba, P,期刊:European Journal of Medicinal Chemistry, 页码:2245-2249 , 文章类型: Article,,卷期:2010年45-6]
- A series of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives have been synthesized. The structures of these compounds were established by IR, H-1 NMR, C-13 NMR, Mass spectral data and elemental an...
- Cell cycle disruption and apoptotic activity of 3-aminothiazolo[3,2a]benzimidazole-2-carbonitrile and its homologues
[作者:Sarhan, AAO; Al-Dhfyan, A; Al-Mozaini, MA; Adra, CN; Aboul-Fadl, T,期刊:European Journal of Medicinal Chemistry, 页码:2689-2694 , 文章类型: Article,,卷期:2010年45-6]
- 3-Aminothiazolo[3,2-a]benzimidazole-2-carbonitrile (2) was prepared and upon hydrolysis using concentrated sulfuric acid or phosphoric acid resulted in the corresponding 3-aminothiazolo[3,2-a] benzimidazole-2-carboxamide...
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