- Design and preparation of aza-analogues of benzo[c]phenanthridine framework with cytotoxic and antiplasmodial activities
[作者:Yapi, AD; Desbois, N; Chezal, JM; Chavignon, O; Teulade, JC; Valentin, A; Blache, Y,期刊:European Journal of Medicinal Chemistry, 页码:2854-2859 , 文章类型: Article,,卷期:2010年45-7]
- Benzo[c]phenanthridine alkaloids represent interesting lead for the discovery of new potential antiplasmodial and/or anticancer drugs. In this field, a novel library of aza-analogs of benzo[c]phenanthroline framework der...
- Synthesis and structure-activity relationship study of 8-hydroxyquinoline-derived Mannich bases as anticancer agents
[作者:Shaw, AY; Chang, CY; Hsu, MY; Lu, PJ; Yang, CN; Chen, HL; Lo, CW; Shiau, CW; Chern, MK,期刊:European Journal of Medicinal Chemistry, 页码:2860-2867 , 文章类型: Article,,卷期:2010年45-7]
- To continue our early study on the structural modifications of clioquinol, more 8-hydroxyquinoline-derived Mannich bases were synthesized and examined for growth-inhibitory effect. Taken Mannich base 1 as our lead compou...
- Prospects for new antimicrobials based on N,N-dimethylbiguanide complexes as effective agents on both planktonic and adhered microbial strains
[作者:Olar, R; Badea, M; Marinescu, D; Chifiriuc, CM; Bleotu, C; Grecu, MN; Iorgulescu, EE; Bucur, M; Lazar, V; Finaru, A,期刊:European Journal of Medicinal Chemistry, 页码:2868-2875 , 文章类型: Article,,卷期:2010年45-7]
- Metal-free N,N-dimethylbiguanidium acetate and novel complexes M(DMBG)(2)(CH3COO)(2)center dot nH(2)O (M: Mn (II), Ni(II), Cu(II) and Zn(II)) were screened for their antimicrobial properties against Gram-positive (Bacill...
- Synthesis and pharmacological evaluation of novel substituted 9-deazaxanthines as A(2B) receptor antagonists
[作者:Nieto, MI; Balo, MC; Brea, J; Caamano, O; Fernandez, F; Garcia-Mera, X; Lopez, C; Loza, MI; Rodriguez-Borges, JE; Vidal, B,期刊:European Journal of Medicinal Chemistry, 页码:2884-2892 , 文章类型: Article,,卷期:2010年45-7]
- A new series of 9-deazaxanthine derivatives with various substituents at the heterocyclic system were synthesized and evaluated for their binding affinities for the four human recombinant adenosine receptors, A(1)-A(3) s...
- Diorganotin(IV) derivatives of ONO tridentate Schiff base: Synthesis, crystal structure, in vitro antimicrobial, anti-leishmanial and DNA binding studies
[作者:Shujha, S; Shah, A; Zia-ur-Rehman; Muhammad, N; Ali, S; Qureshi, R; Khalid, N; Meetsma, A,期刊:European Journal of Medicinal Chemistry, 页码:2902-2911 , 文章类型: Article,,卷期:2010年45-7]
- Six new diorganotin(IV) derivatives of N'-(2-hydroxybenzylidene)formohydrazide (H2L) with general formula R2SnL, where R = Ph (1), Me (2), Bu (3), Oct (4), t-Bu (5), Et (6), and L = [OC6H4CHNNCHO] have been synthesized a...
- Design, synthesis and antiproliferative activity of styryl lactones related to (+)-goniofufurone
[作者:Popsavin, V; Sreco, B; Benedekovic, G; Francuz, J; Popsavin, M; Kojic, V; Bogdanovic, G,期刊:European Journal of Medicinal Chemistry, 页码:2876-2883 , 文章类型: Article,,卷期:2010年45-7]
- This paper describes a straightforward divergent synthesis of (+)-goniofufurone mimics (4, 5 and 6) starting from D-xylose. In a preliminary bioassay, analogues 4 and 5 exhibited a submicromolar antiproliferative activit...
- Synthesis of bile acid derivatives and in vitro cytotoxic activity with pro-apoptotic process on multiple myeloma (KMS-11), glioblastoma multiforme (GBM), and colonic carcinoma (HCT-116) human cell lines
[作者:Brossard, D; El Kihel, L; Clement, M; Sebbahi, W; Khalid, M; Roussakis, C; Rault, S,期刊:European Journal of Medicinal Chemistry, 页码:2912-2918 , 文章类型: Article,,卷期:2010年45-7]
- The novelty of this work derives from the use of nitrogenous heterocycles as building block in the synthesis of conjugate bile acid derivatives. New piperazinyl bile acid derivatives were synthesized and tested in vitro ...
- Inhibitors of the RET tyrosine kinase based on a 2-(alkylsulfanyl)-4-(3-thienyl) nicotinonitrile scaffold
[作者:Brandt, W; Mologni, L; Preu, L; Lemcke, T; Gambacorti-Passerini, C; Kunick, C,期刊:European Journal of Medicinal Chemistry, 页码:2919-2927 , 文章类型: Article,,卷期:2010年45-7]
- In an approach to optimize 2-(4-fluorobenzylsulfanyl)-4-(2-thienyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile (1a), a weak inhibitor of the cancer-related tyrosine kinase RET originating from a screening campaign, analo...
- Synthesis, antiproliferative activity evaluation and structure-activity relationships of novel aromatic urea and amide analogues of N-phenyl-N '-(2-chloroethyl)ureas
[作者:Fortin, S; Moreau, E; Lacroix, J; Cote, MF; Petitclerc, E; C-Gaudreault, R,期刊:European Journal of Medicinal Chemistry, 页码:2928-2937 , 文章类型: Article,,卷期:2010年45-7]
- Seven subsets of aromatic urea and amide analogues of N-phenyl-N'-(2-chloroethyl)ureas (CEU) have been synthesized by nucleophilic addition of 3-chloropropylisocyanate, 2-chloroacetylisocyanate, ethylisocyanate, 2-chloro...
- Novel effects of glycyrrhetinic acid on the central nervous system tumorigenic progenitor cells: Induction of actin disruption and tumor cell-selective toxicity
[作者:Yamaguchi, H; Noshita, T; Yu, T; Kidachi, Y; Kamiie, K; Umetsu, H; Ryoyama, K,期刊:European Journal of Medicinal Chemistry, 页码:2943-2948 , 文章类型: Article,,卷期:2010年45-7]
- Licorice extracts are used worldwide in foods and medicines, and glycyrrhetinic acid (GA) is a licorice component that has been reported to induce various important biological activities. In the present study, we show th...
- Synthesis and evaluation of some new benzothiazole derivatives as potential antimicrobial agents
[作者:Soni, B; Ranawat, MS; Sharma, R; Bhandari, A; Sharma, S,期刊:European Journal of Medicinal Chemistry, 页码:2938-2942 , 文章类型: Article,,卷期:2010年45-7]
- As benzothiazole has proven to be good antimicrobial agent, a novel series of Schiff bases of benzothiazole derivatives were synthesized. Thus condensation of 5-[2-(1,3-benzothiazol-2-yl-amino) ethyl]-4-amino-3-mercapto-...
- Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: Synthesis, evaluation and SAR
[作者:Lee, CY; Chew, EH; Go, ML,期刊:European Journal of Medicinal Chemistry, 页码:2957-2971 , 文章类型: Article,,卷期:2010年45-7]
- The chemopreventive potential of functionalized aurones and related compounds as inducers of NAD(P) H:quinone oxidoreductase 1 (NQO1, EC 1.6.99.2) are described. Several 4,6-dimethoxy and 5-hydroxyaurones induced NQO1 ac...
- Structural determinants of resveratrol for cell proliferation inhibition potency: Experimental and docking studies of new analogs
[作者:Mazue, F; Colin, D; Gobbo, J; Wegner, M; Rescifina, A; Spatafora, C; Fasseur, D; Delmas, D; Meunier, P; Tringali, C; Latruffe, N,期刊:European Journal of Medicinal Chemistry, 页码:2972-2980 , 文章类型: Article,,卷期:2010年45-7]
- Resveratrol is the subject of intense research because of the abundance of this compound in the human diet and as one of the most valuable natural chemopreventive agents. Further advances require new resveratrol analogs ...
|