- Anti-cancer activities of diospyrin, its derivatives and analogues
[作者:Sagar, S; Kaur, M; Minneman, KP; Bajic, VB,期刊:European Journal of Medicinal Chemistry, 页码:3519-3530 , 文章类型: Review,,卷期:2010年45-9]
- Natural products have played a vital role in drug discovery and development process for cancer. Diospyrin, a plant based bisnaphthoquinonoid, has been used as a lead molecule in an effort to develop anticancer drugs. Sev...
- Synthesis and characterization of polyester conjugates of ciprofloxacin
[作者:Sobczak, M,期刊:European Journal of Medicinal Chemistry, 页码:3844-3849 , 文章类型: Article,,卷期:2010年45-9]
- Two-, three-, four and six-arm, star-shaped poly(8-caprolactone) and polylactide homopolymers were synthesized via ring-opening polymerization of cyclic esters in the presence of glycerol, penthaerythritol, dipentaerythr...
- Synthesis and cytotoxic activity of N-((2-methyl-4(3H)-quinazolinon-6-yl)methyl)dithiocarbamates
[作者:Cao, SL; Wang, Y; Zhu, L; Liao, J; Guo, YW; Chen, LL; Liu, HQ; Xu, XZ,期刊:European Journal of Medicinal Chemistry, 页码:3850-3857 , 文章类型: Article,,卷期:2010年45-9]
- A series of N4(2-methyl-4(3H)-quinazolinon-6-yl)methyl)dithiocarbamates 5a-w were synthesized and evaluated for their cytotoxic activity against five human cancer cell lines. We found that compound 5k inhibited prolifera...
- Synthesis and cytotoxic activities of group 3 metal complexes having monoanionic tridentate ligands
[作者:Saturnino, C; Napoli, M; Paolucci, G; Bortoluzzi, M; Popolo, A; Pinto, A; Longo, P,期刊:European Journal of Medicinal Chemistry, 页码:4169-4174 , 文章类型: Article,,卷期:2010年45-9]
- Complexes of scandium, yttrium, samarium and neodymium bearing monoanionic tridentate ancillary ligands have been synthesized and characterized. The cytotoxic activities of novel compounds, as well as that of similar com...
- Antileishmanial activity of ruthenium(II)tetraammine nitrosyl complexes
[作者:Pereira, JCM; Carregaro, V; Costa, DL; da Silva, JS; Cunha, FQ; Franco, DW,期刊:European Journal of Medicinal Chemistry, 页码:4180-4187 , 文章类型: Article,,卷期:2010年45-9]
- The complexes trans-[Ru(NO)(NH3)(4)L](X)(3) (X = BF4-, PF6- or Cl- and L = N-heterocyclic ligands, P (OEt)(3), SO3-2), and [Ru(NO)Hedta)] were shown to exhibit IC50pro in the range of 36 (L = imN) to 5000 mu M (L = imC)....
- Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: Molecular docking study
[作者:El-Azab, AS; Al-Omar, MA; Abdel-Aziz, AAM; Abdel-Aziz, NI; El-Sayed, MAA; Aleisa, AM; Sayed-Ahmed, MM; Abdel-Hamide, SG,期刊:European Journal of Medicinal Chemistry, 页码:4188-4198 , 文章类型: Article,,卷期:2010年45-9]
- Novel derivatives of quinazoline (1-27) have been synthesized and tested for their antitumor activity against three tumor cell lines among these cell lines the human breast carcinoma cell line (MCF-7) in which EGFR is hi...
- Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study
[作者:Newton, AS; Gloria, PMC; Goncalves, LM; dos Santos, DJVA; Moreira, R; Guedes, RC; Santos, MMM,期刊:European Journal of Medicinal Chemistry, 页码:3858-3863 , 文章类型: Article,,卷期:2010年45-9]
- The first structure activity relationship study of vinyl sulfones as caspase-3 inhibitors is reported. A series of 12 vinyl sulfones was synthesized and evaluated for two downstream caspases (caspases-3 and -7). Dipeptid...
- Synthesis and evaluation of 4-quinazolinone compounds as potential antimalarial agents
[作者:Zhu, SR; Wang, J; Chandrashekar, G; Smith, E; Liu, XJ; Zhang, YS,期刊:European Journal of Medicinal Chemistry, 页码:3864-3869 , 文章类型: Article,,卷期:2010年45-9]
- Febrifugine is an alkaloid isolated from Dichroa febrifuga as the active component against Plasmodium falciparum. Adverse side effects have precluded febrifugine as a potential clinical drug. As part of an ongoing malari...
- Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents
[作者:Kamal, A; Balakishan, G; Ramakrishna, G; Shaik, TB; Sreekanth, K; Balakrishna, M; Rajender; Dastagiri, D; Kalivendi, SV,期刊:European Journal of Medicinal Chemistry, 页码:3870-3884 , 文章类型: Article,,卷期:2010年45-9]
- A series of new cinnamido-pyrrolo[2,1-c][1,4)benzodiazepine conjugates (4a-d and 5a-d) and their dimers (6a-d) have been designed, synthesized and evaluated for their biological activity. The anticancer screening of comp...
- Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities
[作者:An, ZY; Yan, YY; Peng, D; Ou, TM; Tan, JH; Huang, SL; An, LK; Gu, LQ; Huang, ZS,期刊:European Journal of Medicinal Chemistry, 页码:3895-3903 , 文章类型: Article,,卷期:2010年45-9]
- A series of graveoline and graveolinine derivatives were synthesized. The biological results showed that most of graveoline derivatives possessed higher cytotoxicity and better inhibitive effect against the adhesion and ...
- Synthesis, structure and in vitro antibacterial activities of new hybrid disinfectants quaternary ammonium compounds: Pyridinium and quinolinium stilbene benzenesulfonates
[作者:Chanawanno, K; Chantrapromma, S; Anantapong, T; Kanjana-Opas, A; Fun, HK,期刊:European Journal of Medicinal Chemistry, 页码:4199-4208 , 文章类型: Article,,卷期:2010年45-9]
- The series of pyridinium (1-10) and quinolinium (11-20) stilbene benzenesulfonates have been synthesized and their structures were investigated by UV-vis, FT-IR and H-1 NMR spectroscopy. In addition, compound 5 was also ...
- Probing the binding site of curcumin in Escherichia coli and Bacillus subtilis FtsZ - A structural insight to unveil antibacterial activity of curcumin
[作者:Kaur, S; Modi, NH; Panda, D; Roy, N,期刊:European Journal of Medicinal Chemistry, 页码:4209-4214 , 文章类型: Article,,卷期:2010年45-9]
- The cytoskeletal protein, FtsZ plays a pivotal role in prokaryotic cell division and is present in majority of the bacterial species. In recent years, inhibitors of FtsZ have been identified that may function as lead com...
- Palladium(II) and platinum(II) complexes of a symmetric Schiff base derived from 2,6,diformyl-4-methylphenol with N-aminopyrimidine: Synthesis, characterization and detection of DNA interaction by voltammetry
[作者:Sonmez, M; Celebi, M; Yardim, Y; Senturk, Z,期刊:European Journal of Medicinal Chemistry, 页码:4215-4220 , 文章类型: Article,,卷期:2010年45-9]
- The two new mononuclear complexes were prepared by reacting symmetric Schiff base, containing pyrimidine rings and the metal chlorides of Pd(II) and Pt(II) in methanol. The mononuclear structure of the complexes was conf...
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