- Synthesis and anti-inflammatory evaluation of novel angularly or linearly fused coumarins
[作者:Symeonidis, T; Fylaktakidou, KC; Hadjipavlou-Litina, DJ; Litinas, KE,期刊:European Journal of Medicinal Chemistry, 页码:5012-5017 , 文章类型: Article,,卷期:2009年44-12]
- Angular [7,8]-fused coumarins were obtained from the reaction of [2,3]-fused phenols with DMAD and PPh3, while linear [6,7]-fused coumarins were formed from the analogous reaction of [3,4]-fused phenols with DMAD and PPh...
- A series of 1, 2-coupled indane dimers with mast cell stabilisation and smooth muscle relaxation properties
[作者:Sheridan, H; Walsh, JJ; Jordan, M; Cogan, C; Frankish, N,期刊:European Journal of Medicinal Chemistry, 页码:5018-5022 , 文章类型: Article,,卷期:2009年44-12]
- Asthma is characterised by bronchoconstriction and inflammation, with infiltration and activation of inflammatory cells such as eosinophils and mast cells, and subsequent release of inflammatory mediators. Much of the th...
- Application of genetic algorithm-support vector machine (GA-SVM) for prediction of BK-channels activity
[作者:Pourbasheer, E; Riahi, S; Ganjali, MR; Norouzi, P,期刊:European Journal of Medicinal Chemistry, 页码:5023-5028 , 文章类型: Article,,卷期:2009年44-12]
- The support vector machine (SVM), which is a novel algorithm from the machine learning community, was used to develop quantitative structure-activity relationship (QSAR) for BK-channel activators. The data set was divide...
- Synthesis and anti-HIV-1 integrase activity of modified dinucleotides
[作者:Aubert, Y; Chassignol, M; Roig, V; Mbemba, G; Weiss, J; Meudal, H; Mouscadet, JF; Asseline, U,期刊:European Journal of Medicinal Chemistry, 页码:5029-5044 , 文章类型: Article,,卷期:2009年44-12]
- The synthesis of a series of thirty-eight new modified dinucleotides and dinucleotide conjugate analogues of d-(5')ApC(3') is described. The inhibitory activity of these compounds toward HIV-1 integrase was examined in e...
- Anti-trypanosomatid benzofuroxans and deoxygenated analogues: Synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies
[作者:Castro, D; Boiani, L; Benitez, D; Hernandez, P; Merlino, A; Gil, C; Olea-Azar, C; Gonzalez, M; Cerecetto, H; Porcal, W,期刊:European Journal of Medicinal Chemistry, 页码:5055-5065 , 文章类型: Article,,卷期:2009年44-12]
- Hybrid vinylthio-, vinylsulfinyl-, vinylsulfonyl- and vinylketo-benzofuroxans developed as anti-trypanosomatid agents, against Trypanosoma cruzi and Leishmania spp., have showed low micromolar IC50 values. The synthetic ...
- Synthesis and antitumor activity studies of some new fused 1,2,4-triazole derivatives carrying 2,4-dichloro-5-fluorophenyl moiety
[作者:Bhat, KS; Poojary, B; Prasad, DJ; Naik, P; Holla, BS,期刊:European Journal of Medicinal Chemistry, 页码:5066-5070 , 文章类型: Article,,卷期:2009年44-12]
- A series of 3-(2,4-dichloro-5-fluorophenyl)-6-(substituted phenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines (4) (Fig. 1) have been synthesized by the cyclization of 3-(2,4-dichloro-5-fluorophenyl)-1,2,4-triazol-5-thiol (...
- A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity
[作者:Guglielmo, S; Bertinaria, M; Rolando, B; Crosetti, M; Fruttero, R; Yardley, V; Croft, SL; Gasco, A,期刊:European Journal of Medicinal Chemistry, 页码:5071-5079 , 文章类型: Article,,卷期:2009年44-12]
- The synthesis and the study of new amodiaquine derivatives bearing modified lateral basic chains as new agents with both antimalarial and antileishmanial activities are reported. The compounds were tested in vitro agains...
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