- Pharmacologic Inhibition of Phospholipid Transfer Protein Activity Reduces Apolipoprotein-B Secretion from Hepatocytes
[作者:Luo, Y; Shelly, L; Sand, T; Reidich, B; Chang, G; MacDougall, M; Peakman, MC; Jiang, XC,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1100-1106 , 文章类型: Article,,卷期:2010年332-3]
- Phospholipid transfer protein (PLTP) plays an important role in atherogenesis, and its function goes well beyond that of transferring phospholipids between lipoprotein particles. Previous studies showed that genetic defi...
- 2,2,2-Trichloroethanol Activates a Nonclassical Potassium Channel in Cerebrovascular Smooth Muscle and Dilates the Middle Cerebral Artery
[作者:Parelkar, NK; Silswal, N; Jansen, K; Vaughn, J; Bryan, RM; Andresen, J,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:803-810 , 文章类型: Article,,卷期:2010年332-3]
- Trichloroacetaldehyde monohydrate [chloral hydrate (CH)] is a sedative/hypnotic that increases cerebral blood flow (CBF), and its active metabolite 2,2,2-trichloroethanol (TCE) is an agonist for the nonclassical two-pore...
- Expression, Localization, and Pharmacological Role of K(v)7 Potassium Channels in Skeletal Muscle Proliferation, Differentiation, and Survival after Myotoxic Insults
[作者:Iannotti, FA; Panza, E; Barrese, V; Viggiano, D; Soldovieri, MV; Taglialatela, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:811-820 , 文章类型: Article,,卷期:2010年332-3]
- Changes in the expression of potassium channels regulate skeletal muscle development. The purpose of this study was to investigate the expression profile and pharmacological role of K(v)7 voltage-gated potassium channels...
- The Effect of Protein Kinase C and G Protein-Coupled Receptor Kinase Inhibition on Tolerance Induced by mu-Opioid Agonists of Different Efficacy
[作者:Hull, LC; Llorente, J; Gabra, BH; Smith, FL; Kelly, E; Bailey, C; Henderson, G; Dewey, WL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1127-1135 , 文章类型: Article,,卷期:2010年332-3]
- Differences in the mechanisms underlying tolerance and mu-opioid receptor desensitization resulting from exposure to opioid agonists of different efficacy have been suggested previously. The objective of this study was t...
- Resveratrol (Trans-3,5,4 '-trihydroxystilbene) Induces Silent Mating Type Information Regulation-1 and Down-Regulates Nuclear Transcription Factor-kappa B Activation to Abrogate Dextran Sulfate Sodium-Induced Colitis
[作者:Singh, UP; Singh, NP; Singh, B; Hofseth, LJ; Price, RL; Nagarkatti, M; Nagarkatti, PS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:829-839 , 文章类型: Article,,卷期:2010年332-3]
- Inflammatory bowel disease is a chronic, relapsing, and tissue-destructive disease. Resveratrol (3,4,5-trihydroxy-trans-stilbene), a naturally occurring polyphenol that exhibits beneficial pleiotropic health effects, is ...
- Antigen-Specific Suppression of Experimental Autoimmune Encephalomyelitis by a Novel Bifunctional Peptide Inhibitor: Structure Optimization and Pharmacokinetics
[作者:Ridwan, R; Kiptoo, P; Kobayashi, N; Weir, S; Hughes, M; Williams, T; Soegianto, R; Siahaan, TJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1136-1145 , 文章类型: Article,,卷期:2010年332-3]
- The objective of this study was to optimize the in vivo activity of proteolipid protein (PLP)-bifunctional peptide inhibitor (BPI) molecule to suppress experimental autoimmune encephalomyelitis (EAE) in SJL/J mice and ev...
- Brain-Permeable Small-Molecule Inhibitors of Hsp90 Prevent alpha-Synuclein Oligomer Formation and Rescue alpha-Synuclein-Induced Toxicity
[作者:Putcha, P; Danzer, KM; Kranich, LR; Scott, A; Silinski, M; Mabbett, S; Hicks, CD; Veal, JM; Steed, PM; Hyman, BT; McLean, PJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:849-857 , 文章类型: Article,,卷期:2010年332-3]
- Aggregation of alpha-synuclein (alpha syn) is a hallmark of sporadic and familial Parkinson's disease (PD) and dementia with Lewy bodies. Lewy bodies contain alpha syn and several heat shock proteins (Hsp), a family of m...
- The Molecular Pharmacology and In Vivo Activity of 2-(4-Chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a Dual Inhibitor of Microsomal Prostaglandin E-2 Synthase-1 and 5-Lipoxygenase
[作者:Koeberle, A; Rossi, A; Zettl, H; Pergola, C; Dehm, F; Bauer, J; Greiner, C; Reckel, S; Hoernig, C; Northoff, H; Bernhard, F; Dotsch, V; Sautebin, L; Schubert-Zsilavecz, M; Werz, O,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:840-848 , 文章类型: Article,,卷期:2010年332-3]
- The microsomal prostaglandin E-2 synthase (mPGES)-1 is one of the terminal isoenzymes of prostaglandin (PG) E-2 biosynthesis. Pharmacological inhibitors of mPGES-1 are proposed as an alternative to nonsteroidal anti-infl...
- A Hybrid Indoloquinolizidine Peptide as Allosteric Modulator of Dopamine D-1 Receptors
[作者:Soriano, A; Vendrell, M; Gonzalez, S; Mallol, J; Albericio, F; Royo, M; Lluis, C; Canela, EI; Franco, R; Cortes, A; Casado, V,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:876-885 , 文章类型: Article,,卷期:2010年332-3]
- The indoloquinolizidine-peptide 28 [(3S,12bR)-N-((S)-1-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(4-fluorophenyl)-1-oxopropan-2ylamino)- 4-cyclohexyl-1-oxobutan-2-yl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a] quinolizine...
- Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand on the Reduction of Joint Inflammation in Experimental Rheumatoid Arthritis
[作者:Jin, CH; Chae, SY; Kim, TH; Yang, HK; Lee, EY; Song, YW; Jo, DG; Lee, KC,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:858-865 , 文章类型: Article,,卷期:2010年332-3]
- This study focused on the potential therapeutic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on collagen-induced arthritis (CIA) and on the elucidation of the mechanisms involved. DBA/1J mice...
- Parstatin(1-26): The Putative Signal Peptide of Protease-Activated Receptor 1 Confers Potent Protection from Myocardial Ischemia-Reperfusion Injury
[作者:Routhu, KV; Tsopanoglou, NE; Strande, JL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:898-905 , 文章类型: Article,,卷期:2010年332-3]
- Parstatin, the N-terminal 41-amino-acid peptide cleaved by thrombin from the protease-activated receptor 1, protects against rat myocardial ischemia and reperfusion injury. In this study, we determined that the parstatin...
- Hepatic Mitochondrial DNA Depletion after an Alcohol Binge in Mice: Probable Role of Peroxynitrite and Modulation by Manganese Superoxide Dismutase
[作者:Larosche, I; Letteron, P; Berson, A; Fromenty, B; Huang, TT; Moreau, R; Pessayre, D; Mansouri, A,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:886-897 , 文章类型: Article,,卷期:2010年332-3]
- Alcohol consumption increases reactive oxygen species (ROS) formation, which can damage mitochondrial DNA (mtDNA) and alter mitochondrial function. To test whether manganese superoxide dismutase (MnSOD) modulates acute a...
- Histamine Potentiates N-Methyl-D-aspartate Receptors by Interacting with an Allosteric Site Distinct from the Polyamine Binding Site
[作者:Burban, A; Faucard, R; Armand, V; Bayard, C; Vorobjev, V; Arrang, JM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:912-921 , 文章类型: Article,,卷期:2010年332-3]
- Histamine potentiates activation of native and recombinant N-methyl-D-aspartate receptors (NMDARs), but its mechanisms of action and physiological functions in the brain remain controversial. Using four different models,...
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