- Human Recombinant Vascular Endothelial Growth Factor Reduces Necrosis and Enhances Hepatocyte Regeneration in a Mouse Model of Acetaminophen Toxicity
[作者:Donahower, BC; McCullough, SS; Hennings, L; Simpson, PM; Stowe, CD; Saad, AG; Kurten, RC; Hinson, JA; James, LP,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:33-43 , 文章类型: Article,,卷期:2010年334-1]
- We reported previously that vascular endothelial growth factor (VEGF) was increased in acetaminophen (APAP) toxicity in mice and treatment with a VEGF receptor inhibitor reduced hepatocyte regeneration. The effect of hum...
- A Novel Autotaxin Inhibitor Reduces Lysophosphatidic Acid Levels in Plasma and the Site of Inflammation
[作者:Gierse, J; Thorarensen, A; Beltey, K; Bradshaw-Pierce, E; Cortes-Burgos, L; Hall, T; Johnston, A; Murphy, M; Nemirovskiy, O; Ogawa, S; Pegg, L; Pelc, M; Prinsen, M; Schnute, M; Wendling, J; Wene, S; Weinberg, R; Wittwer, A; Zweifel, B; Masferrer, J,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:310-317 , 文章类型: Article,,卷期:2010年334-1]
- Autotaxin is the enzyme responsible for the production of lysophosphatidic acid (LPA) from lysophosphatidyl choline (LPC), and it is up-regulated in many inflammatory conditions, including but not limited to cancer, arth...
- Deletion of Microsomal Prostaglandin E Synthase-1 Does Not Alter Ozone-Induced Airway Hyper-Responsiveness
[作者:Wang, MA; Cooper, PR; Jiang, MQ; Zhao, HJ; Hui, YQ; Yao, YB; Tate, JC; Damera, G; Lawson, JA; Jester, WF; Haczku, A; Panettieri, RA; FitzGerald, GA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:63-68 , 文章类型: Article,,卷期:2010年334-1]
- Nonsteroidal anti-inflammatory drugs ameliorate pain and fever by inhibiting cyclooxygenase (COX) and suppressing prostanoid formation. Microsomal prostaglandin E synthase-1 (mPGES-1) catalyzes formation of PGE(2) from t...
- Pharmacological Characterization of Olodaterol, a Novel Inhaled beta(2)-Adrenoceptor Agonist Exerting a 24-Hour-Long Duration of Action in Preclinical Models
[作者:Bouyssou, T; Casarosa, P; Naline, E; Pestel, S; Konetzki, I; Devillier, P; Schnapp, A,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:53-62 , 文章类型: Article,,卷期:2010年334-1]
- The preclinical pharmacological profile of 6-hydroxy-8-[(1R)-1hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one monohydrochloride (olodaterol, previously known as BI 1744 CL), a n...
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