- Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines as potent and highly selective GABA(A) alpha 5 inverse agonists with potential for the treatment of cognitive dysfunction
[作者:Buettelmann, B; Ballard, TM; Gasser, R; Fischer, H; Hernandez, MC; Knoflach, F; Knust, H; Stadler, H; Thomas, AW; Trube, G,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:5958-5961 , 文章类型: Article,,卷期:2009年19-20]
- In a search for GABA(A) alpha 5 ligands that combine high subtype binding selectivity with a marked inverse agonism imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines were identified as a promising class. A short ...
- Synthesis and biological evaluation of new heterocyclic quinolinones as anti-parasite and anti-HIV drug candidates
[作者:Darque, A; Dumetre, A; Hutter, S; Casano, G; Robin, M; Pannecouque, C; Azas, N,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:5962-5964 , 文章类型: Article,,卷期:2009年19-20]
- We have synthesized quinolinones with potential antiparasitic and anti-HIV activities by an original two-step method involving microwave irradiation and have evaluated their activities against Plasmodium falciparum, Leis...
- Discovery of highly potent novel antifungal azoles by structure-based rational design
[作者:Wang, WY; Sheng, CQ; Che, XY; Ji, HT; Cao, YB; Miao, ZY; Yao, JZ; Zhang, WN,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:5965-5969 , 文章类型: Article,,卷期:2009年19-20]
- On the basis of the active site of lanosterol 14 alpha-demethylase from Candida albicans (CACYP51), a series of new azoles were designed and synthesized. All the new azoles show excellent in vitro activity against most o...
- Structure based design of novel irreversible FAAH inhibitors
[作者:Wang, JL; Bowen, SJ; Schweitzer, BA; Madsen, HM; McDonald, J; Pelc, MJ; Tenbrink, RE; Beidler, D; Thorarensen, A,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:5970-5974 , 文章类型: Article,,卷期:2009年19-20]
- Fatty acid amide hydrolase ( FAAH) has attracted significant attention due to its promise as an analgesic target. This has resulted in the discovery of numerous chemical classes as inhibitors of this potential therapeuti...
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