- CD4(+)CD25(+)Foxp3(+) Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury
[作者:D'Alessio, FR; Tsushima, K; Aggarwal, NR; West, EE; Willett, MH; Britos, MF; Pipeling, MR; Brower, RG; Tuder, RM; McDyer, JF; King, LS,期刊:Journal of clinical investigation, 页码:2898-2913 , 文章类型: Article,,卷期:2009年119-10]
- Acute lung injury (ALI) is characterized by rapid alveolar injury, inflammation, cytokine induction, and neutrophil accumulation. Although early events in the pathogenesis of ALI have been defined, the mechanisms underly...
- Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways
[作者:Timmins, JM; Ozcan, L; Seimon, TA; Li, G; Malagelada, C; Backs, J; Backs, T; Bassel-Duby, R; Olson, EN; Anderson, ME; Tabas, I,期刊:Journal of clinical investigation, 页码:2925-2941 , 文章类型: Article,,卷期:2009年119-10]
- ER stress-induced apoptosis is implicated in various pathological conditions, but the mechanisms linking ER stress-mediated signaling to downstream apoptotic pathways remain unclear. Using human and mouse cell culture an...
- Lack of Protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis
[作者:Burstyn-Cohen, T; Heeb, MJ; Lemke, G,期刊:Journal of clinical investigation, 页码:2942-2953 , 文章类型: Article,,卷期:2009年119-10]
- Protein S (ProS) is a blood anticoagulant encoded by the Pros1 gene, and ProS deficiencies are associated with venous thrombosis, stroke, and autoimmunity. These associations notwithstanding, the relative risk that reduc...
- TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice
[作者:Baluk, P; Yao, LC; Feng, J; Romano, T; Jung, SS; Schreiter, JL; Yan, L; Shealy, DJ; McDonald, DM,期刊:Journal of clinical investigation, 页码:2954-2964 , 文章类型: Article,,卷期:2009年119-10]
- Inflammation is associated with blood vessel and lymphatic vessel proliferation and remodeling. The microvasculature of the mouse trachea provides an ideal opportunity to study this process, as Mycoplasma pulmonis infect...
- The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses
[作者:Arhel, N; Lehmann, M; Clauss, K; Nienhaus, GU; Piguet, V; Kirchhoff, F,期刊:Journal of clinical investigation, 页码:2965-2975 , 文章类型: Article,,卷期:2009年119-10]
- Viruses that infect T cells, including those of the lentivirus genus, such as HIV-1, modulate the responsiveness of infected T cells to stimulation by interacting APCs in a manner that renders the T cells more permissive...
- Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
[作者:Regales, L; Gong, YX; Shen, RL; de Stanchina, E; Vivanco, I; Goel, A; Koutcher, JA; Spassova, M; Ouerfelli, O; Mellinghoff, IK; Zakowski, MF; Politi, KA; Pao, W,期刊:Journal of clinical investigation, 页码:3000-3010 , 文章类型: Article,,卷期:2009年119-10]
- EGFR is a major anticancer drug target in human epithelial. tumors. One effective class of agents is the tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib. These drugs induce dramatic responses in indivi...
- The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans
[作者:Charles, KA; Kulbe, H; Soper, R; Escorcio-Correia, M; Lawrence, T; Schultheis, A; Chakravarty, P; Thompson, RG; Kollias, G; Smyth, JF; Balkwill, FR; Hagemann, T,期刊:Journal of clinical investigation, 页码:3011-3023 , 文章类型: Article,,卷期:2009年119-10]
- Cytokines orchestrate the tumor-promoting interplay between malignant cells and the immune system. In many experimental and human cancers, the cytokine TNF-alpha is an important component of this interplay, but its effec...
- Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components
[作者:Neagu, MR; Ziegler, P; Pertel, T; Strambio-De-Castillia, C; Grutter, C; Martinetti, G; Mazzucchelli, L; Grutter, M; Manz, MG; Luban, J,期刊:Journal of clinical investigation, 页码:3035-3047 , 文章类型: Article,,卷期:2009年119-10]
- New World monkeys of the genus Aotus synthesize a fusion protein (AoT5Cyp) containing tripartite motif-containing 5 (TRIM5) and cyclophilin A (CypA) that potently blocks HIV-1 infection. We attempted to generate a human ...
- The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice
[作者:Zhang, JN; Lee, SM; Shannon, S; Gao, BX; Chen, WM; Chen, A; Divekar, R; McBurney, MW; Braley-Mullen, H; Zaghouani, H; Fang, DY,期刊:Journal of clinical investigation, 页码:3048-3058 , 文章类型: Article,,卷期:2009年119-10]
- Although many self-reactive T cells are eliminated by negative selection in the thymus, some of these cells escape into the periphery, where they must be controlled by additional mechanisms. However, the molecular mechan...
|