- Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents
[作者:Patwardhan, AM; Akopian, AN; Ruparel, NB; Diogenes, A; Weintraub, ST; Uhlson, C; Murphy, RC; Hargreaves, KM,期刊:Journal of clinical investigation, 页码:1617-1626 , 文章类型: Article,,卷期:2010年120-5]
- The transient receptor potential vanilloid 1 (TRPV1) channel is the principal detector of noxious heat in the peripheral nervous system. TRPV1 is expressed in many nociceptors and is involved in heat-induced hyperalgesia...
- The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice
[作者:Leviel, F; Hubner, CA; Houillier, P; Morla, L; El Moghrabi, S; Brideau, G; Hatim, H; Parker, MD; Kurth, I; Kougioumtzes, A; Sinning, A; Pech, V; Riemondy, KA; Miller, RL; Hummler, E; Shull, GE; Aronson, PS; Doucet, A; Wall, SM; Chambrey, R; Eladari, D,期刊:Journal of clinical investigation, 页码:1627-1635 , 文章类型: Article,,卷期:2010年120-5]
- Regulation of sodium balance is a critical factor in the maintenance of euvolemia, and dysregulation of renal sodium excretion results in disorders of altered intravascular volume, such as hypertension. The amiloride-sen...
- Control of vaccinia virus skin lesions by long-term-maintained IFN-gamma+TNF-alpha(+) effector/memory CD4(+) lymphocytes in humans
[作者:Puissant-Lubrano, B; Bossi, P; Gay, F; Crance, JM; Bonduelle, O; Garin, D; Bricaire, F; Autran, B; Combadiere, B,期刊:Journal of clinical investigation, 页码:1636-1644 , 文章类型: Article,,卷期:2010年120-5]
- Vaccinia virus (VV) vaccination is used to immunize against smallpox and historically was considered to have been successful if a skin lesion formed at the vaccination site. While antibody responses have been widely prop...
- NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway
[作者:Watanabe, T; Asano, N; Fichtner-Feigl, S; Gorelick, PL; Tsuji, Y; Matsumoto, Y; Chiba, T; Fuss, IJ; Kitani, A; Strober, W,期刊:Journal of clinical investigation, 页码:1645-1662 , 文章类型: Article,,卷期:2010年120-5]
- Nucleotide-binding oligomerization domain 1 (NOD 1) is an intracellular epithelial cell protein known to play a role in host defense at mucosal surfaces. Here we show that a ligand specific for NOD 1, a peptide derived f...
- Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon
[作者:Yu, K; Lujan, R; Marmorstein, A; Gabriel, S; Hartzell, HC,期刊:Journal of clinical investigation, 页码:1722-1735 , 文章类型: Article,,卷期:2010年120-5]
- Anion transport by the colonic mucosa maintains the hydration and pH of the colonic lumen, and its disruption causes a variety of diarrheal diseases. Cholinergic agonists raise cytosolic Ca2+ levels and stimulate anion s...
- LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice
[作者:Bridges, JP; Ikegami, M; Brilli, LL; Chen, XN; Mason, RJ; Shannon, JM,期刊:Journal of clinical investigation, 页码:1736-1748 , 文章类型: Article,,卷期:2010年120-5]
- Respiratory distress syndrome (RDS), which is the leading cause of death in premature infants, is caused by surfactant deficiency. The most critical and abundant phospholipid in pulmonary surfactant is saturated phosphat...
- Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts
[作者:Ye, H; Jeong, SY; Ghosh, MC; Kovtunovych, G; Silvestri, L; Ortillo, D; Uchida, N; Tisdale, J; Camaschella, C; Rouault, TA,期刊:Journal of clinical investigation, 页码:1749-1761 , 文章类型: Article,,卷期:2010年120-5]
- Glutaredoxin 5 (GLRX5) deficiency has previously been identified as a cause of anemia in a zebrafish model and of sideroblastic anemia in a human patient. Here we report that GLRX5 is essential for iron-sulfur cluster bi...
- IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice
[作者:Cho, JS; Pietras, EM; Garcia, NC; Ramos, RI; Farzam, DM; Monroe, HR; Magorien, JE; Blauvelt, A; Kolls, JK; Cheung, AL; Cheng, GH; Modlin, RL; Miller, LS,期刊:Journal of clinical investigation, 页码:1762-1773 , 文章类型: Article,,卷期:2010年120-5]
- Staphylococcus aureus is the most common cause of skin and soft tissue infections, and rapidly emerging antibiotic-resistant strains are creating a serious public health concern. If immune-based therapies are to be an al...
- Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents
[作者:Massa, SM; Yang, T; Xie, YM; Shi, J; Bilgen, M; Joyce, JN; Nehama, D; Rajadas, J; Longo, FM,期刊:Journal of clinical investigation, 页码:1774-1785 , 文章类型: Article,,卷期:2010年120-5]
- Brain-derived neurotrophic factor (BDNF) activates the receptor tropomyosin-related kinase B (TrkB) with high potency and specificity, promoting neuronal survival, differentiation, and synaptic function. Correlations bet...
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