- Inhibitor of kappa B Kinase Beta Regulates Gastric Carcinogenesis via Interleukin-1 alpha Expression
[作者:Sakamoto, K; Hikiba, Y; Nakagawa, H; Hayakawa, Y; Yanai, A; Akanuma, M; Ogura, K; Hirata, Y; Kaestner, KH; Omata, M; Maeda, S,期刊:Gastroenterology, 页码:226-U344 , 文章类型: Article,,卷期:2010年139-1]
- BACKGROUND & AIMS: Nuclear factor-kappa B (NF-kappa B) is an important transcription factor involved in various biological processes, including carcinogenesis. However, it is unknown whether NF-kappa B activation is invo...
- Helicobacter pylori CagL Activates ADAM17 to Induce Repression of the Gastric H, K-ATPase alpha Subunit
[作者:Saha, A; Backert, S; Hammond, CE; Gooz, M; Smolka, AJ,期刊:Gastroenterology, 页码:239-248 , 文章类型: Article,,卷期:2010年139-1]
- BACKGROUND & AIMS: Infection with Helicobacter pylori represses expression of the gastric H, K-adenosine triphosphatase alpha-subunit (HK alpha), which could contribute to transient hypochlorhydria. CagL, a pilus protein...
- Serotonin Signaling Is Altered in Irritable Bowel Syndrome With Diarrhea but Not in Functional Dyspepsia in Pediatric Age Patients
[作者:Faure, C; Patey, N; Gauthier, C; Brooks, EM; Mawe, GM,期刊:Gastroenterology, 页码:249-258 , 文章类型: Article,,卷期:2010年139-1]
- BACKGROUND & AIMS: In adults, irritable bowel syndrome (IBS) and functional dyspepsia (FD) are chronic conditions that often start during childhood. We investigated mucosal serotonin (5-HT) signaling in children with the...
- Hypoxia-Inducible Factor Signaling Provides Protection in Clostridium difficile-Induced Intestinal Injury
[作者:Hirota, SA; Fines, K; Ng, J; Traboulsi, D; Lee, J; Ihara, E; Li, Y; Willmore, WG; Chung, D; Scully, MM; Louie, T; Medlicott, S; Lejeune, M; Chadee, K; Armstrong, G; Colgan, SP; Muruve, DA; MacDonald, JA; Beck, PL,期刊:Gastroenterology, 页码:259-U378 , 文章类型: Article,,卷期:2010年139-1]
- BACKGROUND & AIMS: Clostridium difficile is the leading cause of nosocomial infectious diarrhea. Antibiotic resistance and increased virulence of strains have increased the number of C difficile-related deaths worldwide....
- Replacement of Rbpj With Rbpjl in the PTF1 Complex Controls the Final Maturation of Pancreatic Acinar Cells
[作者:Masui, T; Swift, GH; Deering, T; Shen, CC; Coats, WS; Long, QM; Elsasser, HP; Magnuson, MA; MacDonald, RJ,期刊:Gastroenterology, 页码:270-280 , 文章类型: Article,,卷期:2010年139-1]
- BACKGROUND & AIMS: The mature pancreatic acinar cell is dedicated to the production of very large amounts of digestive enzymes. The early stages of pancreatic development require the Rbpj form of the trimeric Pancreas Tr...
- Human Risk Allele HLA-DRB1*0405 Predisposes Class II Transgenic Ab0 NOD Mice to Autoimmune Pancreatitis
[作者:Freitag, TL; Cham, C; Sung, HH; Beilhack, GF; Durinovic-Bello, I; Patel, SD; Bronson, RT; Schuppan, D; Sonderstrup, G,期刊:Gastroenterology, 页码:281-291 , 文章类型: Article,,卷期:2010年139-1]
- BACKGROUND & AIMS: Autoimmune pancreatitis (AIP) underlies 5%-11% of cases of chronic pancreatitis. An association between AIP and the human leukocyte antigen (HLA)-DRB1*0405/DQB1*0401 haplotype has been reported, but li...
- Dasatinib Inhibits the Development of Metastases in a Mouse Model of Pancreatic Ductal Adenocarcinoma
[作者:Morton, JP; Karim, SA; Graham, K; Timpson, P; Jamieson, N; Athineos, D; Doyle, B; McKay, C; Heung, MY; Oien, KA; Frame, MC; Evans, TRJ; Sansom, OJ; Brunton, VG,期刊:Gastroenterology, 页码:292-303 , 文章类型: Article,,卷期:2010年139-1]
- BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive and metastatic disease for which conventional treatments are of limited efficacy. A number of agents in development are potential anti-invas...
- Activation of Trpv4 Reduces the Hyperproliferative Phenotype of Cystic Cholangiocytes From an Animal Model of ARPKD
[作者:Gradilone, SA; Masyuk, TV; Huang, BQ; Banales, JM; Lehmann, GL; Radtke, BN; Stroope, A; Masyuk, AI; Splinter, PL; LaRusso, NF,期刊:Gastroenterology, 页码:304-U425 , 文章类型: Article,,卷期:2010年139-1]
- BACKGROUND & AIMS: In polycystic liver diseases, cyst formation involves cholangiocyte hyperproliferation. In polycystic kidney (PCK) rats, an animal model of autosomal-recessive polycystic kidney disease (ARPKD), decrea...
- Hepcidin Expression Does Not Rescue the Iron-Poor Phenotype of Kupffer Cells in Hfe-Null Mice After Liver Transplantation
[作者:Garuti, C; Tian, YH; Montosi, G; Sabelli, M; Corradini, E; Graf, R; Ventura, P; Vegetti, A; Clavien, PA; Pietrangelo, A,期刊:Gastroenterology, 页码:315-U434 , 文章类型: Article,,卷期:2010年139-1]
- BACKGROUND & AIMS: Hemochromatosis is a common hereditary disease caused by mutations in HFE and characterized by increased absorption of iron in the intestine. However, the intestine does not appear to be the site of mu...
- Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1 beta in Mice
[作者:Miura, K; Kodama, Y; Inokuchi, S; Schnabl, B; Aoyama, T; Ohnishi, H; Olefsky, JM; Brenner, DA; Seki, E,期刊:Gastroenterology, 页码:323-U453 , 文章类型: Article,,卷期:2010年139-1]
- BACKGROUND & AIMS: Development of nonalcoholic steatohepatitis (NASH) involves the innate immune system and is mediated by Kupffer cells and hepatic stellate cells (HSCs). Toll-like receptor 9 (TLR9) is a pattern recogni...
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