- Methamphetamine directly accelerates beating rate in cardiomyocytes by increasing Ca2+ entry via L-type Ca2+ channel
[作者:Sugimoto, K; Okamura, K; Tanaka, H; Takashima, S; Ochi, H; Yamamoto, T; Matoba, R,期刊:Biochemical and Biophysical Research Communications, 页码:1214-1220 , 文章类型: Article,,卷期:2009年390-4]
- Methamphetamine induces several cardiac dysfunctions, which leads to arrhythmia, cardiac failure and sudden cardiac death. Although these cardiac alterations elicited by methamphetamine were thought to be due to an indir...
- Elastic fiber assembly is disrupted by excessive accumulation of chondroitin sulfate in the human dermal fibrotic disease, keloid
[作者:Ikeda, M; Naitoh, M; Kubota, H; Ishiko, T; Yoshikawa, K; Yamawaki, S; Kurokawa, M; Utani, A; Nakamura, T; Nagata, K; Suzuki, S,期刊:Biochemical and Biophysical Research Communications, 页码:1221-1228 , 文章类型: Article,,卷期:2009年390-4]
- Keloid is a fibrotic disease characterized by abnormal accumulation of extracellular matrix in the dermis. The keloid matrix contains excess collagen and glycosaminoglycans (GAGs), but lacks elastic fiber. However, the r...
- siRNA-mediated knockdown against CDCA1 and KNTC2, both frequently overexpressed in colorectal and gastric cancers, suppresses cell proliferation and induces apoptosis
[作者:Kaneko, N; Miura, K; Gu, ZD; Karasawa, H; Ohnuma, S; Sasaki, H; Tsukamoto, N; Yokoyama, S; Yamamura, A; Nagase, H; Shibata, C; Sasaki, I; Horii, A,期刊:Biochemical and Biophysical Research Communications, 页码:1235-1240 , 文章类型: Article,,卷期:2009年390-4]
- Ndc80 has been shown to play an important role in stable microtubule-kinetochore attachment, chromosome alignment, and spindle checkpoint activation in mitosis. it is composed of two heterodimers, CDCA1-KNTC2 and SPC24-S...
- Lipids modulate H2S/HS- induced NO release from S-nitrosoglutathione
[作者:Tomaskova, Z; Cacanyiova, S; Benco, A; Kristek, F; Dugovicova, L; Hrbac, J; Ondrias, K,期刊:Biochemical and Biophysical Research Communications, 页码:1241-1244 , 文章类型: Article,,卷期:2009年390-4]
- Recently we observed that a gas messenger H2S/HS- released NO from S-nitrosoglutathione (Ondrias et al., Pflugers Arch. 457 (2008) 271-279). However, the effect of biological compounds on the release is not known. Measur...
- The extracellular release of Schistosoma mansoni HMGB1 nuclear protein is mediated by acetylation
[作者:Carneiro, VC; Maciel, RD; da Silva, ICD; da Costa, RFM; Paiva, CN; Bozza, MT; Fantappie, MR,期刊:Biochemical and Biophysical Research Communications, 页码:1245-1249 , 文章类型: Article,,卷期:2009年390-4]
- Schistosoma mansoni HMGB1 (SmHMGB1) was revealed to be a substrate for the parasite histone acetyltransferases SmGCN5 and SmCBP1. We found that full-length SmHMGB1, as well as its HMG-box B (but not HMG-box A) were acety...
- Ellagic acid promotes A beta 42 fibrillization and inhibits A beta 42-induced neurotoxicity
[作者:Feng, Y; Yang, SG; Du, XT; Zhang, X; Sun, XX; Zhao, M; Sun, GY; Liu, RT,期刊:Biochemical and Biophysical Research Communications, 页码:1250-1254 , 文章类型: Article,,卷期:2009年390-4]
- Smaller, soluble oligomers of beta-amyloid (A beta) play a critical role in the pathogenesis of Alzheimer's disease (AD). Selective inhibition of A beta oligomer formation provides an optimum target for AD therapy. Some ...
- A liver X receptor (LXR)-beta alternative splicing variant (LXRBSV) acts as an RNA co-activator of LXR-beta
[作者:Hashimoto, K; Ishida, E; Matsumoto, S; Shibusawa, N; Okada, S; Monden, T; Satoh, T; Yamada, M; Mori, M,期刊:Biochemical and Biophysical Research Communications, 页码:1260-1265 , 文章类型: Article,,卷期:2009年390-4]
- We report the isolation and functional characterization of a novel transcriptional co-activator, termed LXRBSV. LXRBSV is an alternative splicing variant of liver X receptor (LXR)-beta LXRBSV has an intronic sequence bet...
- The binding cavity of mouse major urinary protein is optimised for a variety of ligand binding modes
[作者:Pertinhez, TA; Ferrari, E; Casali, E; Patel, JA; Spisni, A; Smith, LJ,期刊:Biochemical and Biophysical Research Communications, 页码:1266-1271 , 文章类型: Article,,卷期:2009年390-4]
- N-15 and (HN)-H-1 chemical shift data and N-15 relaxation studies have been used to characterise the binding of N-phenyl-naphthylamine (NPN) to mouse major urinary protein (MUP). NPN binds in the beta-barrel cavity of MU...
- miR-139 impacts FoxO1 action by decreasing FoxO1 protein in mouse hepatocytes
[作者:Hasseine, LK; Hinault, C; Lebrun, P; Gautier, N; Paul-Bellon, R; Van Obberghen, E,期刊:Biochemical and Biophysical Research Communications, 页码:1278-1282 , 文章类型: Article,,卷期:2009年390-4]
- FoxO1 is a master regulator of signaling pathways used by growth factors and hormones, including insulin. Its activity is regulated by changes in subcellular localization coupled to post-translational modifications such ...
- Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists
[作者:Kusakabe, M; Watanabe, K; Emoto, N; Aki, N; Kage, H; Nagase, T; Nakajima, J; Yatomi, Y; Ohishi, N; Takai, D,期刊:Biochemical and Biophysical Research Communications, 页码:1283-1287 , 文章类型: Article,,卷期:2009年390-4]
- We recently identified that DNA methylation of the G0S2 gene was significantly more frequent in squamous lung cancer than in non-squamous lung cancer. However, the significance of G0S2 methylation levels on cancer cells ...
- PCSK9 is expressed in pancreatic delta-cells and does not alter insulin secretion
[作者:Langhi, C; Le May, C; Gmyr, V; Vandewalle, B; Kerr-Conte, J; Krempf, M; Pattou, F; Costet, P; Cariou, B,期刊:Biochemical and Biophysical Research Communications, 页码:1288-1293 , 文章类型: Article,,卷期:2009年390-4]
- PCSK9 (Proprotein Convertase Subtilisin Kexin type 9) is a proprotein convertase that plays a key role in cholesterol homeostasis by decreasing hepatic low-density lipoprotein receptor (LDLR) protein expression. Here, we...
- Overexpression of F0F1-ATP synthase alpha suppresses mutant huntingtin aggregation and toxicity in vitro
[作者:Wang, HQ; Xu, YX; Zhao, XY; Zhao, H; Yan, J; Sun, XB; Guo, JC; Zhu, CQ,期刊:Biochemical and Biophysical Research Communications, 页码:1294-1298 , 文章类型: Article,,卷期:2009年390-4]
- Huntington's disease (HD) and other polyglutamine (polyQ) neurodegenerative diseases are characterized by neuronal accumulation of the disease protein, suggesting that the cellular ability to handle abnormal proteins is ...
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