- Reduced Phosphoinositide 3-Kinase (p110 alpha) Activation Increases the Susceptibility to Atrial Fibrillation
[作者:Pretorius, L; Du, XJ; Woodcock, EA; Kiriazis, H; Lin, RCY; Marasco, S; Medcalf, RL; Ming, ZQ; Head, GA; Tan, JW; Cemerlang, N; Sadoshima, J; Shioi, T; Izumo, S; Lukoshkova, EV; Dart, AM; Jennings, GL; McMullen, JR,期刊:American Journal of Pathology, 页码:998-1009 , 文章类型: Article,,卷期:2009年175-3]
- Atrial fibrillation (AF) is the most common sustained arrhythmia presenting at cardiology departments. A limited understanding of the molecular mechanisms responsible for the development of AF has hindered treatment stra...
- Functional Consequences of Mitochondrial DNA Deletions in Human Skin Fibroblasts Increased Contractile Strength in Collagen Lattices Is Due to Oxidative Stress-Induced Lysyl Oxidase Activity
[作者:Majora, M; Wittkampf, T; Schuermann, B; Schneider, M; Franke, S; Grether-Beck, S; Wilichowski, E; Bernerd, F; Schroeder, P; Krutmann, J,期刊:American Journal of Pathology, 页码:1019-1029 , 文章类型: Article,,卷期:2009年175-3]
- Deletions within the mitochondrial DNA (mtDNA) are thought to contribute to extrinsic skin aging. To study the translation of mtDNA deletions into functional and structural changes in the skin, we seeded human skin fibro...
- Beta-Catenin Activation Promotes Liver Regeneration after Acetaminophen-Induced Injury
[作者:Apte, U; Singh, S; Zeng, G; Cieply, B; Virji, MA; Wu, T; Monga, SPS,期刊:American Journal of Pathology, 页码:1056-1065 , 文章类型: Article,,卷期:2009年175-3]
- Acute liver failure (ALF) remains a disease with poor patient outcome. improved prognosis is associated with spontaneous liver regeneration, which supports the relevance of exploring 'regenerative' therapies. Therefore, ...
- Intestinal Glucose Uptake Protects Liver from Lipopolysaccharide and D-Galactosamine, Acetaminophen, and Alpha-Amanitin in Mice
[作者:Zanobbio, L; Palazzo, M; Gariboldi, S; Dusio, GF; Cardani, D; Mauro, V; Marcucci, F; Balsari, A; Rumio, C,期刊:American Journal of Pathology, 页码:1066-1076 , 文章类型: Article,,卷期:2009年175-3]
- We have recently observed that oral administration of D-glucose saves animals from lipopolysaccharide (LPS)-induced death. This effect is the likely consequence of glucose-induced activation of the sodium-dependent gluco...
- Natural Killer Cells Modulate Overt Autoimmunity to Homeostasis in Nonobese Diabetic Mice after Anti-CD3 F(ab ')(2) Antibody Treatment through Secreting Transforming Growth Factor-beta
[作者:Chen, GJ; Han, GC; Wang, JN; Wang, RX; Xu, RN; Shen, BF; Qian, JH; Li, Y,期刊:American Journal of Pathology, 页码:1086-1094 , 文章类型: Article,,卷期:2009年175-3]
- Recently, the anti-CD3 antibody has been shown to be a promising candidate for the efficient treatment of overt autoimmunity. However, the mechanisms underlying this effect remain unclear. Our previous studies demonstrat...
- Systemic and Local Interleukin-17 and Linked Cytokines Associated with Sjogren's Syndrome Immunopathogenesis
[作者:Katsifis, GE; Rekka, S; Moutsopoulos, NM; Pillemer, S; Wahl, SM,期刊:American Journal of Pathology, 页码:1167-1177 , 文章类型: Article,,卷期:2009年175-3]
- Recently recognized as a distinct CD4(+) T helper (Th) lineage, Th17 cells have been implicated in host responses to infections and in pathogenesis associated with autoimmune diseases. This cytokine is implicated in prim...
- Expression of Parathyroid-Specific Genes in Vascular Endothelial Progenitors of Normal and Tumoral Parathyroid Glands
[作者:Corbetta, S; Belicchi, M; Pisati, F; Meregalli, M; Eller-Vainicher, C; Vicentini, L; Beck-Peccoz, P; Spada, A; Torrente, Y,期刊:American Journal of Pathology, 页码:1200-1207 , 文章类型: Article,,卷期:2009年175-3]
- Parathyroid tissue is able to spontaneously induce angiogenesis, proliferate, and secrete parathyroid hormone when autotransplanted in patients undergoing total parathyroidectomy. Angiogenesis is also involved in parathy...
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