- A Mouse Model of Inducible Liver Injury Caused by Tet-On Regulated Urokinase for Studies of Hepatocyte Transplantation
[作者:Song, XJ; Guo, YS; Duo, SG; Che, J; Wu, C; Ochiya, T; Ding, MX; Deng, HK,期刊:American Journal of Pathology, 页码:1975-1983 , 文章类型: Article,,卷期:2009年175-5]
- Mouse models of liver injury provide useful tools for studying hepatocyte engraftment and proliferation. A representative model of liver injury is the albumin-urokinase (Alb-uPA) transgenic model, but neonatal lethality ...
- Local Interleukin-1-Driven Joint Pathology Is Dependent on Toll-Like Receptor 4 Activation
[作者:Abdollahi-Roodsaz, S; Joosten, LAB; Koenders, MI; van den Brand, BT; van de Loo, FAJ; van den Berg, WB,期刊:American Journal of Pathology, 页码:2004-2013 , 文章类型: Article,,卷期:2009年175-5]
- Toll-like receptors (TLRs) may contribute to the pathogenesis of chronic inflammatory destructive diseases through the recognition of endogenous ligands produced on either inflammation or degeneration of the extracellula...
- Viral RNA Induces Type I Interferon-Dependent Cytokine Release and Cell Death in Mesangial Cells via Melanoma-Differentiation-Associated Gene-5 Implications for Viral Infection-Associated Glomerulonephritis
[作者:Flur, K; Allam, R; Zecher, D; Kulkarni, OP; Lichtnekert, J; Schwarz, M; Beutler, B; Vielhauer, V; Anders, HJ,期刊:American Journal of Pathology, 页码:2014-2022 , 文章类型: Article,,卷期:2009年175-5]
- Viral RNA can trigger interferon signaling in dendritic cells via the innate recognition receptors melanoma-differentiation-associated gene (MDA)-5 and retinod-inducible gene (RIG)-I in the cytosol or via Toll-like recep...
- Type I Interferon Modulates Monocyte Recruitment and Maturation in Chronic Inflammation
[作者:Lee, PY; Li, Y; Kumagai, Y; Xu, Y; Weinstein, JS; Kellner, ES; Nacionales, DG; Butfiloski, EJ; van Rooijen, N; Akira, S; Sobel, ES; Satoh, M; Reeves, WH,期刊:American Journal of Pathology, 页码:2023-2033 , 文章类型: Article,,卷期:2009年175-5]
- Chronic inflammation is characterized by continuous recruitment and activation of immune cells such as monocytes in response to a persistent stimulus. Production of proinflammatory mediators by monocytes leads to tissue ...
- Interferon-gamma Differentially Affects Alzheimer's Disease Pathologies and Induces Neurogenesis in Triple Transgenic-AD Mice
[作者:Mastrangelo, MA; Sudol, KL; Narrow, WC; Bowers, WJ,期刊:American Journal of Pathology, 页码:2076-2088 , 文章类型: Article,,卷期:2009年175-5]
- inflammatory processes, including the episodic and/or chronic elaboration of cytokines, have been identified as playing key roles in a number of neurological disorders. Whether these activities impart a disease-resolving...
- Strain Differences in Behavioral and Cellular Responses to Perinatal Hypoxia and Relationships to Neural Stem Cell Survival and Self-Renewal Modeling the Neurovascular Niche
[作者:Li, Q; Liu, JM; Michaud, M; Schwartz, ML; Madri, JA,期刊:American Journal of Pathology, 页码:2133-2145 , 文章类型: Article,,卷期:2009年175-5]
- Premature infants have chronic hypoxia, resulting in cognitive and motor neurodevelopmental. handicaps caused by suboptimal neural stem cell (NSC) repair/recovery in neurogenic zones (including the subventricular and the...
- beta(3)-Integrin Expression on Tumor Cells Inhibits Tumor Progression, Reduces Metastasis, and Is Associated with a Favorable Prognosis in Patients with Ovarian Cancer
[作者:Kaur, S; Kenny, HA; Jagadeeswaran, S; Zillhardt, MR; Montag, AG; Kistner, E; Yamada, SD; Mitra, AK; Lengyel, E,期刊:American Journal of Pathology, 页码:2184-2196 , 文章类型: Article,,卷期:2009年175-5]
- The role of the vitronectin receptor (alpha(v)beta(3)-integrin) as a tumor promoter seems well established, and, consequently, therapies that block this integrin are currently in clinical testing. We undertook the curren...
- Activated cAMP Response Element Binding Protein Is Overexpressed in Human Mesotheliomas and Inhibits Apoptosis
[作者:Shukla, A; Bosenberg, MW; MacPherson, MB; Butnor, KJ; Heintz, NH; Pass, HI; Carbone, M; Testa, JR; Mossman, BT,期刊:American Journal of Pathology, 页码:2197-2206 , 文章类型: Article,,卷期:2009年175-5]
- Little is known about the cellular mechanisms contributing to the development and chemoresistance of malignant mesothelioma (MM), an aggressive asbestos-associated tumor. A human mesothelial cell line (LP9/TERT-1) and is...
- Nodal Lymphangiogenesis and Metastasis Role of Tumor-Induced Lymphatic Vessel Activation in Extramammary Paget's Disease
[作者:Hirakawa, S; Detmar, M; Kerjaschki, D; Nagamatsu, S; Matsuo, K; Tanemura, A; Kamata, N; Higashikawa, K; Okazaki, H; Kameda, K; Nishida-Fukuda, H; Mori, H; Hanakawa, Y; Sayama, K; Shirakata, Y; Tohyama, M; Tokumaru, S; Katayama, I; Hashimoto, K,期刊:American Journal of Pathology, 页码:2235-2248 , 文章类型: Article,,卷期:2009年175-5]
- Nodal lymphangiogenesis promotes distant lymph node (LN) metastasis in experimental cancer models. However, the role of nodal lymphangiogenesis hi distant metastasis and in the overall survival of cancer patients remains...
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