- Endothelial von Willebrand Factor Release Due to eNOS Deficiency Predisposes to Thrombotic Microangiopathy in Mouse Aging Kidney
[作者:Nakayama, T; Sato, W; Yoshimura, A; Zhang, L; Kosugi, T; Campbell-Thompson, M; Kojima, H; Croker, BP; Nakagawa, T,期刊:American Journal of Pathology, 页码:2198-2208 , 文章类型: Article,,卷期:2010年176-5]
- Endothelial dysfunction is critical in the decline of renal function with. By using endothelial nitric oxide synthase knockout (eNOSKO) mice, we tested the hypothesis that a lack of endothelial nitric oxide synthase acce...
- Ventilator-Induced Inflammatory Response in Lipopolysaccharide-Exposed Rat Lung Is Mediated by Angiotensin-Converting Enzyme
[作者:Wosten-van Asperen, RM; Lutter, R; Specht, PAC; van Woensel, JB; van der Loos, CM; Florquin, S; Lachmann, B; Bos, AP,期刊:American Journal of Pathology, 页码:2219-2227 , 文章类型: Article,,卷期:2010年176-5]
- Angiotensin-converting enzyme (ACE) mediates the ventilator-induced inflammatory response in healthy lungs via angiotensin II (Ang II). A rat model was used to examine the role of ACE and Ang II in the inflammatory respo...
- Lack of Glycoprotein 130/Signal Transducer and Activator of Transcription 3-Mediated Signaling in Hepatocytes Enhances Chronic Liver Injury and Fibrosis Progression in a Model of Sclerosing Cholangitis
[作者:Plum, W; Tschaharganeh, DF; Kroy, DC; Corsten, E; Erschfeld, S; Dierssen, U; Wasmuth, H; Trautwein, C; Streetz, KL,期刊:American Journal of Pathology, 页码:2236-2246 , 文章类型: Article,,卷期:2010年176-5]
- The 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) model leads to chronic cholestatic liver injury and therefore resembles human diseases such as sclerosing cholangitis and forms of metabolic liver diseases. The role of...
- Human Intestinal Ischemia-Reperfusion-Induced Inflammation Characterized Experiences from a New Translational Model
[作者:Grootjans, J; Lenaerts, K; Derikx, JPM; Matthijsen, RA; de Bruine, AP; van Bijnen, AA; van Dam, RM; Dejong, CHC; Buurman, WA,期刊:American Journal of Pathology, 页码:2283-2291 , 文章类型: Article,,卷期:2010年176-5]
- Human intestinal ischemia-reperfusion (IR) is a frequent phenomenon carrying high morbidity and mortality. Although intestinal IR-induced inflammation has been studied extensively in animal models, human intestinal IR in...
- HIF1A Overexpression Is Associated with Poor Prognosis in a Cohort of 731 Colorectal Cancers
[作者:Baba, Y; Nosho, K; Shima, K; Irahara, N; Chan, AT; Meyerhardt, JA; Chung, DC; Giovannucci, EL; Fuchs, CS; Ogino, S,期刊:American Journal of Pathology, 页码:2292-2301 , 文章类型: Article,,卷期:2010年176-5]
- Tissue hypoxia commonly occurs in tumors. Hypoxia-inducible factor (HIF)-1 and HIF-2, which are essential mediators of cellular response to hypoxia, regulate gene expression for tumor angiogenesis, glucose metabolism, an...
- Synoviocyte-Derived Angiopoietin-Like Protein 2 Contributes to Synovial Chronic Inflammation in Rheumatoid Arthritis
[作者:Okada, T; Tsukano, H; Endo, M; Tabata, M; Miyata, K; Kadomatsu, T; Miyashita, K; Semba, K; Nakamura, E; Tsukano, M; Mizuta, H; Oike, Y,期刊:American Journal of Pathology, 页码:2309-2319 , 文章类型: Article,,卷期:2010年176-5]
- Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by symmetrical polyarticular synovitis of the diarthrodial joints. Several proinflammatory cytokines derived from both infiltrating inflammatory c...
- Suppressor of Cytokine Signaling-2 Gene Disruption Promotes Apc(Min/+) Tumorigenesis and Activator Protein-1 Activation
[作者:Newton, VA; Ramocki, NM; Scull, BP; Simmons, JG; McNaughton, K; Lund, PK,期刊:American Journal of Pathology, 页码:2320-2332 , 文章类型: Article,,卷期:2010年176-5]
- Epigenetic in vitro and in vivo studies suggest that suppressor of cytokine signaling-2 (SOCS2) may normally limit tumorigenesis in the intestine; however, this theory has not been directly tested. We hypothesized that S...
- Immature Osteoblast Lineage Cells Increase Osteoclastogenesis in Osteogenesis Imperfecta Murine
[作者:Li, HT; Jiang, X; Delaney, J; Franceschetti, T; Bilic-Curcic, I; Kalinovsky, J; Lorenzo, JA; Grcevic, D; Rowe, DW; Kalajzic, I,期刊:American Journal of Pathology, 页码:2405-2413 , 文章类型: Article,,卷期:2010年176-5]
- This study addressed the role of impairment of osteoblastic differentiation as a mechanism underlying pathophysiology of the osteogenesis imperfecta (OI). We hypothesized that combination of impaired osteogenic different...
- Forced Expression of Methionine Adenosyltransferase 1A in Human Hepatoma Cells Suppresses in Vivo Tumorigenicity in Mice
[作者:Li, JP; Ramani, K; Sun, ZF; Zee, C; Grant, EG; Yang, HP; Xia, M; Oh, P; Ko, K; Mato, JM; Lu, SC,期刊:American Journal of Pathology, 页码:2456-2466 , 文章类型: Article,,卷期:2010年176-5]
- Methionine adenosyltransferase (MAT) catalyzes the synthesis of S-adenosylmethionine, the principal methyl donor, and is encoded by MAT1A and MAT2A in mammals. Normal liver expresses MAT1A, which is silenced in hepatocel...
- LC3A-Positive Light Microscopy Detected Patterns of Autophagy and Prognosis in Operable Breast Carcinomas
[作者:Sivridis, E; Koukourakis, MI; Zois, CE; Ledaki, I; Ferguson, DJP; Harris, AL; Gatter, KC; Giatromanolaki, A,期刊:American Journal of Pathology, 页码:2477-2489 , 文章类型: Article,,卷期:2010年176-5]
- Autophagy is a self-degradation mechanism by which cells recycle their own cytoplasmic constituents and dispose of excess or defective organelles after starvation and oxygen deprivation. An antibody to the microtubule-as...
- Characterization of a Model of an Arteriovenous Fistula in the Rat The Effect of L-NAME
[作者:Croatt, AJ; Grande, JP; Hernandez, MC; Ackerman, AW; Katusic, ZS; Nath, KA,期刊:American Journal of Pathology, 页码:2530-2541 , 文章类型: Article,,卷期:2010年176-5]
- Vascular access dysfunction contributes to the mortality of patients undergoing chronic hemodialysis. The present study analyzed the changes that evolve in a femoral arteriovenous fistula in the rat. The venous segment o...
- Dimethylarginine Dimethylaminohydrolase Overexpression Ameliorates Atherosclerosis in Apolipoprotein E-Deficient Mice by Lowering Asymmetric Dimethylarginine
[作者:Jacobi, J; Maas, R; Cardounel, AJ; Arend, M; Pope, AJ; Cordasic, N; Heusinger-Ribeiro, J; Atzler, D; Strobel, J; Schwedhelm, E; Boger, RH; Hilgers, KF,期刊:American Journal of Pathology, 页码:2559-2570 , 文章类型: Article,,卷期:2010年176-5]
- Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is increasingly recognized as a novel biomarker in cardiovascular disease. To date, it remains unclear whether elevated ADMA levels ar...
- Estrogen Receptor alpha Controls a Gene Network in Luminal-Like Breast Cancer Cells Comprising Multiple Transcription Factors and MicroRNAs
[作者:Cicatiello, L; Mutarelli, M; Grober, OMV; Paris, O; Ferraro, L; Ravo, M; Tarallo, R; Luo, SJ; Schroth, GP; Seifert, M; Zinser, C; Chiusano, ML; Traini, A; De Bortoli, M; Weisz, A,期刊:American Journal of Pathology, 页码:2113-2130 , 文章类型: Article,,卷期:2010年176-5]
- Luminal-like breast tumor cells express estrogen receptor alpha (ER alpha), a member of the nuclear receptor family of ligand-activated transcription factors that controls their proliferation, survival, and functional st...
- Subcellular Localization of Activated AKT in Estrogen Receptor- and Progesterone Receptor-Expressing Breast Cancers Potential Clinical Implications
[作者:Badve, S; Collins, NR; Bhat-Nakshatri, P; Turbin, D; Leung, S; Thorat, M; Dunn, SE; Geistlinger, TR; Carroll, JS; Brown, M; Bose, S; Teitell, MA; Nakshatri, H,期刊:American Journal of Pathology, 页码:2139-2149 , 文章类型: Article,,卷期:2010年176-5]
- Activated v-AKT murine thymoma viral oncogene homolog 1 (AKT)/protein kinase B (PKB) kinase (pAKT) is localized to the plasma membrane, cytoplasm, and/or nucleus in 50% of cancers. The clinical importance of pAKT localiz...
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